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| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | Analysis and design for the second order nonlinear continuous extended states observer显示文摘The extended state observer (ESO) is a novel observer for a class of uncertain systems. Since ESO adopts the continuous non-smooth structure, the classical observer design theory is hard to use for ESO analysis. In this note, the self-stable region (SSR) approach, which is a nonlinear synthesis method for nonlinear uncertain systems, will be used for ESO design and its stability analysis. The advantages of the non-smooth structure in ESO for improving the convergence properties and the estimation precision will be shown. | Yi Huang Jingqing Han | 2000 | Chinese Science Bulletin2000，45，21： | 65 |
| 3 | Failure mechanism and coupled static-dynamic loading theory in deep hard rock mining: A review显示文摘Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the explanation for these failure phenomena using existing dynamic or static rock mechanics theory is not straightforward.In this study,new theory and testing method for deep underground rock mass under coupled static-dynamic loading are introduced.Two types of coupled loading modes,i.e.'critical static stress + slight disturbance' and 'elastic static stress + impact disturbance',are proposed,and associated test devices are developed.Rockburst phenomena of hard rocks under coupled static-dynamic loading are successfully reproduced in the laboratory,and the rockburst mechanism and related criteria are demonstrated.The results of true triaxial unloading compression tests on granite and red sandstone indicate that the unloading can induce slabbing when the confining pressure exceeds a certain threshold,and the slabbing failure strength is lower than the shear failure strength according to the conventional Mohr-Column criterion.Numerical results indicate that the rock unloading failure response under different in situ stresses and unloading rates can be characterized by an equivalent strain energy density.In addition,we present a new microseismic source location method without premeasuring the sound wave velocity in rock mass,which can efficiently and accurately locate the rock failure in hard rock mines.Also,a new idea for deep hard rock mining using a non-explosive continuous mining method is briefly introduced. | Xibing Li Fengqiang Gong Ming Tao Longjun Dong Kun Du Chunde Ma Zilong Zhou Tubing Yin | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 68 |
| 4 | Sequential blood purification therapy for critical patients with hyperlipidemic severe acute pancreatitis显示文摘AIM: To evaluate the efficacy of sequential blood purification therapy in the treatment of critical patients with hyperlipidemic severe acute pancreatitis.METHODS: Thirty-one intensive care unit(ICU) patients with hyperlipidemic severe acute pancreatitis treated at the Second Affiliated Hospital of Harbin Medical University were divided into either a study group(n = 15; July 1, 2012 to June 30, 2014) or a control group(n = 16; July 1, 2010 to June 30, 2012) based on the implementation of sequential blood purification therapy. The control group received continuous venous-venous hemofiltration(CVVH) on the basis of conventional treatments, and the therapeutic dose of CVVH was 30 m L/kg per hour. The study group received sequential plasma exchange and CVVH on the basis of conventional treatments. The anticoagulation regimen of CVVH is the regional citrate anticoagulation. Mortality rate on day 28, rates of systemic and local complications, duration of ICU, and time to target serum lipid level, as well as physiologic and laboratory indices were compared between the two groups.RESULTS: The mortality rate on day 28 was significantly lower in the study group than in the control group(13.33% vs 37.50%; P < 0.05). The duration of ICU stay was significantly shorter in the study group than in the control group(7.4 ± 1.35 d vs 9.19 ± 2.99 d, P < 0.05). The time to target serum lipid level was significantly shorter in the study group than in the control group(3.47 ± 0.52 d vs 7.90 ± 1.14 d, P < 0.01). There were no significant differences in the rates of systemic complications and local complications between the two groups(60% vs 50% and 80% vs 81%, respectively). In the comparisons of physiologic and laboratory indices, serum albumin and C-reactive protein were significantly better in the study group than in the control group after treatment(37.8 ± 4.6 g/L vs 38.9 ± 5.7 g/L, and 20.5 ± 6.4 mg/L vs 28.5 ± 7.1 mg/L, respectively, both P < 0.05). With the exception of plateletcrit, no other indices showed significant differences between the two groups.CONCLUSION: Sequential blood purification therapy is effective in the treatment of ICU patients with hyperlipidemic severe acute pancreatitis and can improve patient prognosis. | Hong-Liang Wang Kai-Jiang Yu | 2015 | World Journal of Gastroenterology2015，21，20： | 57 |
| 5 | Arterial spin labeling in neuroimaging显示文摘Arterial spin labeling(ASL) is a magnetic resonance imaging technique for measuring tissue perfusion using a freely diffusible intrinsic tracer.As compared with other perfusion techniques,ASL offers several advantages and is now available for routine clinical practice in many institutions.Its noninvasive nature and ability to quantitatively measure tissue perfusion make ASL ideal for research and clinical studies.Recent technical advances have increased its sensitivity and also extended its potential applications.This review focuses on some basic knowledge of ASL perfusion,emerging techniques and clinical applications in neuroimaging. | Sasitorn Petcharunpaisan Joana Ramalho Mauricio Castillo | 2010 | World Journal of Radiology2010，2，10： | 23 |
| 6 | 连续体结构拓扑优化应力约束凝聚化的ICM方法显示文摘为克服应力约束下拓扑优化问题约束数目多、应力敏度计算量大的困难,提出了应力约束化凝聚化的ICM方法.在利用Mises强度理论将应力约束转换成应变能约束后,提出了应力约束凝聚化的两条途径:其一为应力全局化的方法,其二为应力约束集成化的方法.由此建立了多工况下以重量为目标、以凝聚化应变能为约束的连续体结构优化模型,并利用对偶理论对优化模型进行了求解.4个数值算例表明:该方法具有较高的计算效率,得到的拓扑结构比较合理,不仅适用于二维连续体结构,也适用于三维连续体结构. | 隋允康 叶红玲 彭细荣 张学胜 | 2007 | 力学学报2007，39，4： | 22 |
| 7 | Influence of Panax ginseng Continuous Cropping on Metabolic Function of Soil Microbial Communities显示文摘Objective To investigate the influence of Panax ginseng continuous cropping on the carbon substrate metabolic activity of microbes in soils sampled from Dafang,Huangni,and Wulidi in Jilin Province,China.Methods Soil metabolisms of soil communities were characterized by community level physiological profiles using BIOLOGTM EcoPlate.Results Soils sampled from the three sites were analyzed and their metabolic activities were compared.Principal component analysis explored the significant variance in metabolic function of microbial communities in soils,though the Shannon index and the evenness index of them were similar.Futhermore,two principal components(PC1 and PC2),which contributed 67.83% and 10.78% of total variance,were extracted respectively.And also,substrates significantly correlated with PC1 and PC2 at the three sampling sites were identified.Conclusion Characteristic of soil is the primary factor influencing microbial communities,and P.ginseng continuous cropping has significant influence on microbial community.Though soil samples show similar microbial metabolic profiles,microbial communities in rhizosphere soil are changed obviously during the cultivation of P.ginseng,which would finally result in the unbalance of microbial community.Phytopathogens would gradually be the predominants in rhizosphere soil and make P.ginseng sick. | YING Yi-xin1,DING Wan-long1,ZHOU Ying-qun2,LI Yong1 1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China 2.China National Corporation of Traditional and Herbal Medicine,Beijing 100195,China | 2012 | Chinese Herbal Medicines2012，4，4： | 17 |
| 8 | Double-stream-pouring technique for production of gradient materials by continuous casting显示文摘A novel method for producing gradient materials by continuous casting is introduced. By using many-stream-pouring technique, samples with gradient distribution of alloy composition along the cross section have been prepared. The main difference of this method from the conventional continuous casting is the pouring system equipped with two sets of tundishes for liquid metals of different alloy compositions. Special consideration is given to the promotion and control of the cross-sectional mass transport. The steady heat transfer and mass flow ensure a partial mixing of two metals and yield a continously varying composition distribution. By adjusting the processing parameters, composition profile with different shapes can be achieved. First experiments have been carried out in Al-Si system and Al-Cu system for three series of Al/AlSi, AlSi/Al and AlCu/Al. It is shown that the alloy composition, the microstructure and the mechanical property change smoothly from the centre to the surface of the samples. This simple and practical method is potential for mass prodution of 'structural gradient materials' and may offer a new way for alloy design. | Zhang Weiwen Zhu Cangshan Wei Xingzhao Meng Jilong Yuan Shugui Yu Ge | 1998 | Chinese Science Bulletin1998，43，11： | 16 |
| 9 | 应力约束处理为应变能集成的连续体结构拓扑优化显示文摘为克服应力约束下拓扑优化问题约束多、应力敏度计算量大的困难,本文提出了将应力约束处理为应变能集成的结构拓扑优化ICM方法。文中用几个典型算例对该方法进行了检验,结果表明:本方法优化效率较高,而且得到的结构最优拓扑较为合理。 | 隋允康 张学胜 龙连春 | 2007 | 计算力学学报2007，24，5： | 16 |
| 10 | Some New Fixed Point Theorems in Probabilistic Metric Spaces显示文摘SOMENEWFIXEDPOINTTHEOREMSINPROBABILISTICMETRICSPACESzhuChuan-xi(朱传喜)(MathematiesDivision,Nanchang.University,Nanchang)(Receiv... | 朱传喜 | 1995 | Applied Mathematics and Mechanics(English Edition)1995，16，2： | 14 |
| 11 | Effects of plasma exchange combined with continuous renal replacement therapy on acute fatty liver of pregnancy显示文摘BACKGROUND: Acute fatty liver of pregnancy (AFLP) in the third trimester or early postpartum period can lead to fatal liver damage. Its traditional therapy is not very effective in facilitating hepatic recovery. The safety and effect of plasma exchange (PE)in combination with continuous renal replacement therapy(CRRT) (PE+CRRT) for AFLP still needs evaluation.METHODS: Five AFLP patients with hepatic encephalopathy and renal failure were subjected to PE+CRRT in our department from 2007 to 2012. Their symptoms, physical signs and results were observed, and all relevant laboratory tests were compared before and after PE+CRRT.RESULTS: All the 5 patients were well tolerated to the therapy. Four of them responded to the treatment and showed improvement in clinical symptoms/signs and laboratory results and they were cured and discharged home after the treatment One patient succeeded in bridging to transplantation for slowing down hepatic failure and its complications process after2 treatment sessions. Intensive care unit stay and hospital stay were 9.4 (range 5-18) and 25.0 days (range 11-42), respectively.CONCLUSION: PE+CRRT is safe and effective and should be used immediately at the onset of hepatic encephalopathy and/or renal failure in patients with AFLP. | Cheng-Bo Yu Jia-Jia Chen Wei-Bo Du Ping Chen Jian-Rong Huang Yue-Mei Chen Hong-Cui Cao Lan-Juan Li | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 14 |
| 12 | Effect of a new health education model on continuous nursing in elderly patients with diabetes mellitus显示文摘Objective: We aimed to explore the effect of a new health education model on continuous nursing care in elderly patients with diabetes mellitus who had undergone an operation for fracture.Methods: Convenience sampling was used to select 59 elderly patients with diabetes mellitus and fracture. New health education methods were used, and patient parameters were evaluated before and after the intervention.Results: Evaluation of medication, reasonable diet, regular exercise, blood glucose monitoring, and regular follow-up compliance were significantly improved in the experimental group compared to the control group(P<0.05). There were also significant differences between groups in fasting blood glucose, 2-hour postprandial blood glucose, triglyceride, high-density lipoprotein, and low-density lipoprotein levels(P < 0.05); however, the differences between groups in terms of glycosylated hemoglobin and total cholesterol levels were not statistically significant(P > 0.05). Finally, the functional recovery and mental health of the experimental group were significantly better than those of the control group(P < 0.05).Conclusions: The implementation of a menu of voluntary services in community-based continuous nursing provided standardized nursing care for elderly patients with fracture and diabetes mellitus and improved their quality of life. | Jing-Jing Chao Ya-Zhuo Xue | 2018 | Frontiers of Nursing2018，5，1： | 14 |
| 13 | Three-Dimensional Thermo-mechanical Coupled FEM Simulation for Hot Continuous Rolling of Large-Diameter Mandrel Bar显示文摘Based on the important boundary conditions of rolling simulation including friction, heat conduction and interactionsof the workpiece and rolls, the hot continuous rolling processes of large-diameter mandrel round bar (200 mm indiameter) in 6VH-stand hot tandem mill are successfully simulated by three-dimensional coupled thermomechanicalelastoplastic finite element method (FEM). The distributions of stress, strain, temperature and the rolling force andtorque for the two-pass and four-pass continuous rolling are calculated respectively. Thus, the two and four-passroll schedules are verified, respectively. The simulation results show that it is safe to produce 200 mm round barby the two-pass (oval pass and round pass) continuous rolling on the existing equipment compared to the four-passcontinuous rolling. There are concave surfaces and increased widths occurring at the end of rolled billet due touneven deformations between the outside and inside of the workpiece as well as the free spreading close to the rollgap of the final pass. | Huiping HONG Yonglin KANG Changtao FENG Xiqiang CHEN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 13 |
| 14 | The spatial scaling effect of continuous canopy Leaves Area Index retrieved by remote sensing显示文摘Leave Area Index (LAI) is one of the most basic parameters to describe the geometric structure of plant canopies. It is also important input data for climatic model and interaction model between Earth surface and atmosphere, and some other things. The spatial scaling of retrieved LAI has been widely studied in recent years. Based on the new canopy reflectance model, the mechanism of the scaling effect of con- tinuous canopy Leaf Area Index is studied, and the scaling transform formula among different scales is found. Both the numerical simulation and the field validation show that the scale transform formula is reliable. | XU XiRu FAN WenJie TAO Xin | 2009 | Science China Earth Sciences2009，52，3： | 12 |
| 15 | Recent Development of Steelmaking Process in Sumitomo Metals显示文摘Sumitomo Metal Ind.is the third place steelmaking company for productivity in Japan.Although,we have some first Japanese innovations results in steelmaking process.In this report,SRP process and some topics for continuous casting have been introduced. | Masayuki Kawamoto | 2011 | Journal of Iron and Steel Research(International)2011，18，S2： | 12 |
| 16 | Generation of GHZ-like and cluster-like quadripartite entangled states for continuous variable using a set of quadrature squeezed states显示文摘We designed the experimental generation system of the optical GHZ-like and cluster-like quadripartite entangled states for continuous variables.We theoretically demonstrated that the two different types of quadripartite entangled states can be obtained by the linearly optical transformation of four amplitude-quadrature and phase-quadrature squeezed states produced from a pair of nondegenerate optical parametric amplifiers under appropriate phase relations.The criteria for full inseparability of quadripartite cluster-like state were deduced,and the dependency of the quadripartite entanglement on the initial squeezing degree,the transmission efficiencies of the system and the detection efficiency of homodyne detection were numerically calculated. | SU XiaoLong JIA XiaoJun XIE ChangDe PENG KunChi | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，1： | 12 |
| 17 | Study of the seismic performance of expansion double spherical seismic isolation bearings for continuous girder bridges显示文摘The development of an expansion double spherical seismic isolation (DSSI) bearing by modifying the fixed DSSI bearing is described in this paper. The expansion DSSI bearing is characterized by its good energy dissipation and horizontal displacement capacity and has been successfully integrated into the seismic design of several important engineering projects in China. It is envisioned to be used as a substitute for ordinary expansion bearings in continuous girder bridges to distribute the longitudinal earthquake action among all the piers. Its development, configuration and working mechanism are introduced first. The test method and the seismic performance of an expansion DSSI bearing are then briefly described. A theoretical analysis followed by a numerical analysis for an actual four-span continuous girder bridge are provided as an example, and it is concluded that the expansion DSSI bearing can be integrated into the seismic design of continuous girder bridges. | Peng, Tianbo Yu, Xuntao Wang, Zhennan Han, Lei | 2012 | Earthquake Engineering and Engineering Vibration2012，11，2： | 11 |
| 18 | A topological position of the set of continuous maps in the set of upper semicontinuous maps显示文摘Let (X, ρ) be a metric space and ↓USCC(X) and ↓CC(X) be the families of the regions below all upper semi-continuous compact-supported maps and below all continuous compact-supported maps from X to I = [0, 1], respectively. With the Hausdorff-metric, they are topological spaces. In this paper, we prove that, if X is an infinite compact metric space with a dense set of isolated points, then (↓USCC(X), ↓CC(X)) ≈ (Q, c0 ∪ (Q \ Σ)), i.e., there is a homeomorphism h :↓USCC(X) → Q such that h(↓CC(X)) = c0 ∪ (Q \ Σ), where Q = [-1, 1]ω, Σ = {(xn)n∈N∈ Q : sup|xn| < 1} and c0 = {(xn)n∈N∈Σ : limn→+∞ xn = 0}. Combining this statement with a result in our previous paper, we have (↓USCC(X), ↓CC(X)) ≈■ (Q, c0 ∪ (Q \ Σ)), if the set of isolanted points is dense in X, (Q, c0), otherwise, if X is an infinite compact metric space. We also prove that, for a metric space X, (↓USCC(X), ↓CC(X)) ≈ (Σ,c0) if and only if X is non-compact, locally compact, non-discrete and separable. | YANG ZhongQiang WU NaDa | 2009 | Science China Mathematics2009，52，8： | 11 |
| 19 | Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea:Possible Relationship with Counteracting Oxidative Stress显示文摘This work is aimed at exploring the clinical efficacy of continuous positive airway pressuie(CPAP)in treatment of patients with arrhythmias combined with obstructive sleep apnea(OSA).Through evaluating serum native thiol,malonaldehyde(MDA)and nicotinamide adenine dinucleotide phosphate oxidase(NADPH oxidase)in these patients and describing the effects on oxidative parameters of CPAP therapy for 3 months,we confirmed the impact of oxidative stress on arrhythmias.A total of 64 patients with OSA combined with arrhythmias were collected from April 2014 to April 2017 with full clinical information.Patients were divided into two groups(paired experiment design):32 patients in group A(control group),who received unchanged anti-arrhythmia treatment and 32 patients in group B,who were subjected to unchanged pharmacological anti-arrhythmia therapy combined with CPAP.OSA related parameters were compared between the two groups after 3-month therapy.And the levels of parameters of oxidative stress in patients were measured before and after CPAP therapy.After 3 months of CPAP therapy,compared with the control group,the percentage of sage N3(NREM 3)and stage R(REM)in total sleep time was significantly increased,while apnea-hypopnea index(AHI)and the Epworth Sleepiness Scale(ESS)score were evidently decreased.Meanwhile,the lowest oxygen saturation(LSpCh)was also elevated after CPAP treatment for 3 months.The CPAP therapy significantly prevented the occurrence of arrhythmias(P<0.05).Both the MDA level and NADPH oxidase levels were significantly lower in the group B than in the group A(P<0.05).But serum native thiol was improved by CPAP treatment(P<0.05).In conclusion,proper use of CPAP therapy provides significant benefits for the treatment of arrhythmia in patients with OSA. | Xiao-ting WANG Gang ZHAO Ling TU Zhi-yong YUE Zhen-hua LIU Jie HAN Kun GAO Xuan-chen ZHOU Shuai XU Jian-feng LI | 2019 | Current Medical Science2019，39，1： | 10 |
| 20 | Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress显示文摘The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy.The present study aimed to clarify the dynamic changes of depression-like behavior,dentate gyrus neurogenesis and hippocampal miR-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression treatment.Chronic unpredictable mild stress depression models were established by exposing Sprague-Dawley rats to various mild stressors,including white noise,thermal swimming,stroboscopic illumination,soiled cages,pairing with three other stressed animals,cold swimming,tail pinch,restraint and water and food deprivation.Chronic unpredictable mild stress model rats underwent dynamic observation from 1 to 8 weeks and were compared with a control group(normal feeding without any stressors).To observe changes in the depression-like behavior phenotype during chronic unpredictable mild stress-induced depression,a sucrose preference test was used to evaluate the degree of anhedonia.An open-field test was used to evaluate locomotor activity and anxiety status.Compared with the control group,chronic unpredictable mild stress rats lost weight but did not have a depression-like behavioral phenotype at 1-4 weeks.Chronic unpredictable mild stress rats presented decreased sucrose preference and locomotor activity at 5-8 weeks.In addition,chronic unpredictable mild stress rats did not have significant anxiety-like behavior during 1-8 weeks of modeling.To observe neurogenesis dysfunctions and changes in neuronal number in the dentate gyrus during chronic unpredictable mild stress-induced depression,markers(DCX and DCX/BrdU)of neural proliferation and differentiation and the neuronal marker NeuN were assessed by immunofluorescence.Compared with the control group,neurogenesis and the neuronal number in the dentate gyrus did not change from 2 to 6 weeks;however,neural proliferation and differentiation in the dentate gyrus decreased,and the number of neurons decreased until the eighth week in the chronic unpredictable mild stress group.Real-time quantitative reverse transcription polymerase chain reaction assays and fluorescence in situ hybridization were used to measure the expression of hippocampal miR-124 during chronic unpredictable mild stress-induced depression.The results showed that the expression of hippocampal miR-124 was unchanged during the first 4 weeks but increased from 5 to 6 weeks and decreased from 7 to 8 weeks compared with the control group.These findings indicate that during chronic unpredictable mild stress-induced depression,the behavioral phenotype,miR-124 expression in the hippocampus,neurogenesis in the dentate gyrus and neuronal numbers showed dynamic changes,which suggested that various pathological changes occur at different stages of depression.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Guangzhou University of Chinese Medicine of China in March 2015. | Yun-Ling Huang Ning-Xi Zeng Jie Chen Jie Niu Wu-Long Luo Ping Liu Can Yan Li-Li Wu | 2020 | Neural Regeneration Research2020，15，6： | 10 |
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