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| 1 | A comparative review of HLA associations with hepatitis Band C viral infections across global populations显示文摘Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC). Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment. Extensive literature search was conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLA DR13 is consistently associated with HBV clearance globally. HLADRB1*11/*12 alleles and DQB1*0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class Ⅰmolecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific therapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations. | Rashmi Singh Rashmi Kaul Anil Kaul Khalid Khan | 2007 | World Journal of Gastroenterology2007，13，12： | 31 |
| 2 | Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients显示文摘AIM: To study the relationship of human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles with the genetic susceptibility to HBV infection and the response to interferon (IFN) in HBV-infected patients.METHODS: Low-resolution DNA typing kit was used to determine HLA-DR-1 and -DQB1 genes in 72 patients with chronic hepatitis B (CHB) and HLA-DRB1 in 200 healthy people ready to donate their bone marrow in Shanghai.Among CHB patients, 35 were treated with IFNα-1b for 24 wk.RESULTS: The frequencies of HLA-DRB1*06, DRB1*08and DRB1*16 alleles in 72 patients were higher than in 200 healthy people (2.08% vs0%, OR = 3.837, P= 0.018;11.11% vs5.50%, OR = 2.148, P= 0.034; and 6.94% vs 3.00%, OR = 0.625, P = 0.049, respectively); whereas that of DRB1*07 allele was lower (2.78% vs 7.75%,OR = 0.340, P = 0.046). The frequency of HLA-DRB1* 14allele was higher in 11 responders to IFN compared with 24 non-responders (18.18% vs2.08%, OR = 10.444,P = 0.031), whereas that of DQB1*07 allele was inverse (9.09% vs 37.50%, OR = 0.167, P= 0.021).CONCLUSION: The polymorphism of HLA class Ⅱ may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment.Compared with other HLA-DQB1 alleles, HLA-DQB1*07 may be associated with low response rate to IFN. | Yong-Nian Han Jin-Long Yang Shui-Gen Zheng Qun Tang Wei Zhu | 2005 | World Journal of Gastroenterology2005，11，36： | 28 |
| 3 | 中国人群HLA-DRB1基因多态性与慢性乙型肝炎关系的Meta分析显示文摘目的:用Meta分析的方法综合评价中国人群HLA-DRB1基因多态性与慢性乙型肝炎的关系.方法:检索中国生物医学文献数据库、维普数据库和Medline数据库,依据选择标准收集所有相关的病例对照研究,应用RevMan4.2软件对符合条件的研究结果进行Meta分析.结果:符合纳入标准的共8篇文献,包含慢性乙型肝炎组501例和正常对照组855例.经综合分析:HLA-DRB1*03和HLA-DRB1*08可能为中国人群慢性乙型肝炎的易感性基因型(OR=2.44,95%CI:1.65-3.61,P<0.00001;OR=1.57,95%CI:1.08-2.28,P=0.02);HLA-DRB1*13和HLA-DRB1*15可能是我国人群慢性乙型肝炎的保护性基因型(OR=0.40,95%CI:0.21-0.79,P=0.008;OR=0.64,95%CI:0.46-0.90,P=0.01).结论:中国人群慢性乙型肝炎的发生与HLADRB1基因的多态性有关,与其他国家人群既有相同点,也有其自身特点. | 骆峻 金安娜 吴旭东 喻荣彬 | 2006 | 世界华人消化杂志2006，14，31： | 19 |
| 4 | Host susceptibility to persistent hepatitis B virus infection显示文摘基因传染病学研究象成双的研究那样,研究提供了的肝炎 B (HBV ) 感染研究和种族差别聚类家庭招待基因因素玩的证据在决定 HBV 感染的结果的一个重要角色。开的问题包括基因在感染是哪个人重要的并且怎么发现他们。尽管很多研究寻求了在 HBV 感染 / 坚持和基因多型性之间的基因协会,候选人基于基因的途径清楚地是不适当的充分解释疾病的基因基础。与新基因标记和自动化 genotyping 的来临,基因印射能被进行极其快速。这条途径在某传染病是成功的。连接分析能发现主人基因易受影响到 HBV 并且具有大临床的重要性。 | Ying-Li He Ying-Ren Zhao Shu-Lin Zhang Shu-Mei Lin | 2006 | World Journal of Gastroenterology2006，12，30： | 11 |
| 5 | 慢性无症状HBV携带者阴虚体质与人类白细胞抗原-DRB1、DQA1基因多态性的联系显示文摘目的探讨慢性无症状HBV携带者(chronic asymptomatic HBV carrier,ASC)阴虚体质与人类白细胞抗原(human leukocyte antigen,HLA)-DRB1、HLA-DQA1基因多态性的内在联系。方法将105例ASC患者进行中医体质分型及分组:阴虚质组47例和非阴虚质组58例。采用聚合酶链反应-序列特异性引物(PCR-SSP)技术测定HLA-DRB1、HLA-DQA1等位基因型。结果阴虚质组HLA-DRB1*09、HLA-DQA1*0301的基因频率明显低于非阴虚质组(分别为12.1%vs27.8%,19.1%vs39.7%),差异有统计学意义(P<0.01);HLA-DRB1*11、HLA-DQA1*0501的基因频率明显高于非阴虚质组(分别为12.1%vs4.3%,28.7%vs9.5%),差异有统计学意义(P<0.05,P<0.01)。结论 HLA-DRB1*09和HLA-DQA1*0301可能是ASC非阴虚体质患者的分子基础;HLA-DRB1*11和HLA-DQA1*0501可能是ASC阴虚体质患者的分子基础。 | 过建春 肖丽娜 荀运浩 王宇芳 李春青 石伟珍 施军平 | 2012 | 中国中西医结合杂志2012，32，8： | 11 |
| 6 | Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections:A meta-analysis显示文摘AIM:To assess the rigorous relationship between human leukocyte antigens(HLA)-DR alleles and outcomes of hepatitis B virus(HBV) infections by means of metaanalysis.METHODS:Medline/PubMed,EMBASE,CNKI and VIP were searched to identify relevant studies.Study quality was evaluated using the Newcastle-Ottawa Scale.Odds ratios(OR) and 95% confidence interval(95% CI) were pooled using Stata 11.0.Subgroup analyses were performed by ethnicity.Heterogeneity and publication bias analyses were performed to validate the credibility.RESULTS:A total of 2609 patients with chronic hepatitis B and 2606 controls spontaneously recovering from prior HBV infection were included.Meta-analysis showed that HLA-DR*04(OR = 0.72,95% CI:0.60-0.85) and DR*13(OR = 0.27,95% CI:0.19-0.37) alleles were significantly associated with HBV clearance while patients carrying HLA-DR*03(OR = 1.47,95% CI:1.16-1.87) or DR*07(OR = 1.59,95% CI:1.24-2.03) alleles had a significantly increased risk of chronic HBV persistence.For the HLA-DR*01 polymorphism,a significantly association with HBV clearance was found in Chinese Han group(OR = 0.48,95% CI:0.26-0.86),but not found in other ethnic groups(P = 0.191).For other polymorphisms,no association with the HBV infection outcome was found.CONCLUSION:HLA-DR*04 and DR*13 alleles may be the protective factors for HBV clearance and HLADR*03,and DR*07 alleles may be the risk factors for HBV persistence. | Ze-Hui Yan Yi Fan Xiao-Hong Wang Qing Mao Guo-Hong Deng Yu-Ming Wang | 2012 | World Journal of Gastroenterology2012，18，24： | 10 |
| 7 | 乙型肝炎分子流行病学研究进展显示文摘乙肝的分子流行病学是运用先进的分子生物学技术研究乙肝流行病学的诸多问题,能够进一步从分子水平阐明乙型肝炎病毒感染的病因、致病过程及发病机制,对于疾病早期诊断、传染性的评估、病情的预测、抗病毒药物疗效的观察、疾病发展进程的监测和乙肝感染自然史的研究等方面均有重要的指导意义。针对近几年乙肝分子流行病学研究的几个热点即乙型肝炎病毒的检测、基因分型、基因系统进化分析、基因变异、基因多态性的研究进展作一回顾。虽然近年来该领域的研究迅速增多,但多数仍处于探索阶段,乙肝病毒感染、清除等诸多机制的研究仍任重而道远。 | 纪惠玲 郭燕 郑能雄 | 2008 | 国际免疫学杂志2008，31，1： | 8 |
| 8 | Curative effects of interferon-α and HLA-DRB1-DQA1 and-DQB1 alleles in chronic viral hepatitis B显示文摘AIM: To investigate the association between curative effects of interferon-α and partial human leucocyte antigen (HLA)Ⅱ alleles in chronic viral hepatitis B.METHODS: Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-α for 6 mo. HLA-DRB1, -DQA1, and -DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) method. RESULTS: Frequencies of HLA-DRB1*04(P<0.025) and HLA-DQA1*0303 (P<0.01) in non-responders were significantly higher than those in partial and complete responders. Frequencies of HLA-DQAI*0505(P<0.025) and HLA-DQB1*0301(P<0.005) in partial and complete responders were significantly higher than those in non-responders.CONCLUSION: Non-response to interferon-α therapy is positively correlated with HLA-DRB1*04 and HLA-DQA1*0303, and negatively correlated with HLA-DQA1*0505 and -DQB1*0301 in patient with chronic viral hepatitis B.HLA Ⅱ genes of the identification alleles provide a method for evaluating outcome of interferon-α treatment. | Guo-QingZang MinXi Ming-LiangFeng YunJi Yong-ShengYu Zheng-HaoTang | 2004 | World Journal of Gastroenterology2004，10，14： | 6 |
| 9 | 人类白细胞抗原Ⅱ基因对乙型肝炎病毒易感性和干扰素抗病毒治疗的影响显示文摘目的 探讨人类白细胞抗原 (HLA) DRB1和 DQB1等位基因多态性是对乙型肝炎病毒 (HBV)易感性及干扰素 (IFN)抗HBV治疗的影响。方法 应用聚合酶链反应 序列特异性引物 (PCR SSP)技术检测上海地区 6 9例慢性乙型肝炎 (CHB)患者的HLA DRB1和 DQB1等位基因以及 2 0 0名健康准骨髓捐献者的HLA DRB1等位基因。其中 32例接受α 1b干扰素治疗 2 4周。结果 CHB患者HLA DRB1 0 6和 DRB1 0 8等位基因的频度高于健康人 (2 .17%对 0 % ,RR =3.96 3,95 %CI :3.4 2 5~ 4 .5 85 ,P =0 .0 17;11.5 9%对 5 .5 0 % ,RR=2 .2 5 3,95 %CI:1.14 7~ 4 .4 2 8,P =0 .0 2 1) ;而DRB1 0 7等位基因的频度则低于健康人 (2 .90 %对 7.75 % ,RR=0 .35 5 ,95 %CI:0 .12 3~ 1.0 2 5 ,P =0 .0 4 7)。IFN治疗的患者中 ,10例应答者DRB1 14等位基因频度高于 2 2例非应答者 (2 0 .0 %对 2 .3% ,RR =10 .75 0 ,95 %CI :1.116~ 10 3.5 5 8,P =0 .0 30 ) ;而DQB1 0 7分布则相反(10 .0 %对 38.6 % ,RR =0 .176 ,95 %CI :0 .0 36~ 0 .85 6 ,P =0 .0 2 2 )。结论 HLA等位基因多态性可能与上海地区人群HBV的易感性和IFN抗HBV治疗有关。与其他HLA DRB1等位基因比较 ,HLA DRB1 0 6和 DRB1 0 8可能与HBV易感性有关 ,而HLA DRB1 0 7则相反 ,? | 韩永年 杨金龙 郑水根 汤群 游龙英 张工梁 杨影 | 2004 | 上海医学2004，27，6： | 6 |
| 10 | 从“肾虚邪伏”认识慢性乙型肝炎显示文摘目的:整理'肾虚邪伏'的由来,结合现代医学对'肾虚邪伏'的认识,探讨乙型肝炎病毒持续感染的原因,探索研究乙肝慢性化的中医病机实质,为临床治疗慢性乙型肝炎提供新思路。方法:古代及现代医学研究文献整理。结果:'肾虚邪伏'是导致HBV持续感染,即乙型病毒性肝炎慢性化的主要原因之一,HBV持续感染又可能与人类白细胞抗原有关,其中HLA-DQB1与慢性乙型病毒的感染、治疗、预后具有紧密的联系。结论:从'肾虚邪伏'认识慢性乙型肝炎可能为治疗慢性乙型肝炎提供新思路新方法。 | 张凤 冯全生 郭尹玲 党思捷 | 2016 | 成都中医药大学学报2016，39，3： | 5 |
| 11 | 兰州地区慢性乙型肝炎与人类白细胞抗原-DRB1等位基因关系的初探显示文摘目的 探讨人类白细胞抗原(HLA) DRB1基因频率与乙型肝炎病毒感染的相关性。方法 用聚合酶 链反应/序列特异性引物法对兰州地区汉族健康者48例、慢性乙型肝炎患者53例和急性乙型肝炎感染者21例进行 HLA DRB1等位基因分型,并作相关性分析。结果 兰州地区慢性乙型肝炎组HLA DRB1 07X的频率明显高于健 康对照组和急性自限性感染组(P<0.05)。结论 HLA DRB1 07X可能与兰州地区汉族慢性乙型肝炎感染相关, 免疫遗传因素参与慢性乙型肝炎的发病机制。 | 周彬 李文凡 居军 马惠民 | 2005 | 临床荟萃2005，20，6： | 5 |
| 12 | HLA-DRB1*13等位基因与我国汉族人群慢性乙型肝炎关联性的Meta分析显示文摘目的:用Meta分析的方法综合评价HLA-DRB1*13等位基因与我国汉族人群慢性乙型肝炎关联性。方法:检索中国生物医学文献数据库、维普数据库和Medline数据库,依据纳入与排除标准,收集所有相关的病例对照研究,应用RevMan4.2软件对符合条件的研究结果进行Meta分析。结果:符合纳入标准的共6篇文献,合计包含CHB组335例,正常对照组659例,经Egger’s检验未见显著发表偏倚。经综合分析:合并OR值为0.40,95%CI为0.21~0.79(P=0.008),认为HLA-DRB1*13等位基因是我国汉族人群慢性乙型肝炎发生的保护因素。结论:HLA-DRB1*13等位基因与我国汉族人群慢性乙型肝炎的发生具有统计学关联性,且为保护性基因。 | 金安娜 骆峻 吴旭东 陈轶玉 马恩才 | 2006 | 南京医科大学学报(自然科学版)2006，26，12： | 4 |
| 13 | TNF-α基因启动子多态性与HBV感染转归的关系显示文摘目的:探讨中国汉族人肿瘤坏死因子-α(tumor necrosis fac- tor-α,TNF-α)基因启动子单核苷酸多态性与乙型肝炎病毒(hepatitis B virus,HBV)感染结果之间的关系. 方法:慢性乙型肝炎患者131例,HBV感染自愈者165组. 应用聚合酶链反应-限制性片段长度多态性分析方法,检测HBV感染自愈者和慢性乙型肝炎患者TNF-α基因启动子-238G/A,-308G/A,-857C/T和-863C/A单核苷酸多态性位点基因型. 结果:对慢性乙型肝炎组和HBV感染自愈组人群TNF-α基因启动子区域的-238G/A,-308G/A,-857C/T和-863C/A 4个SNP位点进行基因型分析,共发现12种启动子基因型,以GG·GG·CC·CC,GG·GG·CC·CA,GG·GG·CT·CC和GG·GA·CC·CC基因型多见,约占85%.通过对慢性乙型肝炎患者和HBV感染自愈者TNF-α基因启动子4个位点基因型联合分析发现,GG·GG·CC·CC, GG·GG·CC·CA和GG·GA·CC·CC基因型在慢性乙型肝炎组和HBV感染自愈组分布差异有显著性,其中携带GG·GG·CC·CC基因型的个体患慢性乙型肝炎的机会比(odds ratio,OR)为2.15,95%可信区间为1.34-3.45;而携带GG·GG·CC·CA或GG·GA·CC·CC基因型的个体患慢性乙型肝炎的OR分别为0.48(95%可信区间为0.27-0.86)和0.35(95%可信区间为0.14-0.89).HBV感染的清除可能与GG·GG·CC·CA(X2=6.14,P=0.013<0.05) 和/或GG·GA·CC·CC(X2=5.18,P=0.023<0.05)基因型有关.进一步对各位点单核苷酸多态性分析发现, 慢性乙型肝炎患者和HBV感染自愈者TNF-α基因启动子-238G/A、-857C/T位点基因型分布频率差异无显著性,而-308G/A,-863C/A位点基因型分布频率差异有显著性(-308G/A位点,)X2=6.53,P=0.011<0.05,OR=3.05; -863C/A位点,X2=4.33,P=0.037<0.05,OR=1.69). 结论:TNF-α基因启动子-308G/A、-863C/A位点多态性与中国汉族人HBV感染后的结果有关,其中TNF-α-308G/A 和/或-863C/A位点A等位基因的存在可能有利于HBV感染的清除. | 张平安 李艳 向萍霞 吴健民 | 2004 | 世界华人消化杂志2004，12，9： | 4 |
| 14 | 慢性乙型肝炎和肝硬化及肝癌与HLA-DQA1基因多态性关系的研究显示文摘目的:研究HLA-DQA1等位基因多态性与慢性乙型肝炎(HBV)病毒感染、肝硬化及肝癌的关系。方法:采用聚合酶链序列特异性引物(PCR-SSP)技术分别对168例慢性HBV感染者(包括48例慢性乙型肝炎、42例乙型肝炎肝硬化和78例乙型肝炎后肝癌患者)以及100例对照(感染后自发恢复者)进行HLA-DQA1等位基因的检测。结果:慢性HBV感染者HLA-DQA1*0102的表型频率显著低于对照组(25.6%vs47.0%,OR=0.39,Pc=0.003),DQA1*0601表型频率高于对照组(4.2%vs0,OR=0.96,P=0.039),但后者差异无统计学意义(Pc>0.05)。肝硬化患者DQA1*0104的表型频率显著低于无肝硬化患者(6.4%vs28.4%,OR=0.17,Pc=0.001),DQA1*0201的表型频率高于无肝硬化患者(27.7%vs12.2%,OR=2.76,P=0.014),但后者差异无统计学意义(Pc>0.05)。HLA-DQA1各等位基因的表型频率在肝癌患者与非肝癌患者间差异无统计学意义。结论:HLA-DQA1*0102等位基因可能降低慢性HBV感染的风险,而DQA1*0104等位基因可能降低乙型肝炎肝硬化的风险。乙型肝炎后肝癌的发生与HLA-DQA1等位基因无明显相关性。 | 刘春涛 程宝泉 张宗利 | 2007 | 中国现代普通外科进展2007，10，5： | 3 |
| 15 | 福建地区乙型肝炎肝硬化与人类白细胞抗原DRB1基因的相关性显示文摘目的:研究人类白细胞抗原(human leucocyte antgen,HLA)-DRB1基因多态性与福建汉族人乙型肝炎肝硬化的遗传易感性关系.方法:以93例福建地区汉族人群乙型肝炎肝硬化患者为研究对象,以同一地区84例健康人为对照人群,采用DNA测序分型技术(sequencing-based typing,SBT)对HLA-DRB1等位基因精确分型,计算各组等位基因频率,对照人群等位基因分布进行Hardy-Weinberg遗传平衡检验,应用遗传统计方法进行关联分析,确定与乙型肝炎肝硬化相关的易感基因及基因型.结果:乙型肝炎肝硬化组HLA-DRB1*04等位基因频率明显高于对照组(OR=2.536,95%CI:1.292-4.978,P=0.0068),HLA-DRB1*1101等位基因频率明显低于对照组(OR=0.339,95%CI:0.119-0.964,P=0.0425);HLA-DRB104基因型在病例组与对照组之间分布差异具有统计学意义(OR=3.456,95%CI:1.553-7.692,c2=9.227,P=0.0024),乙型肝炎肝硬化与HLA-DRB04基因型剂量线性相关(OR=2.457,95%CI:1.274-4.737,c2=7.197,P=0.0073).结论:HLA-DRB1*04主型等位基因及其基因型可能是乙型肝炎肝硬化的易感基因,HLA-DRB1*1101等位基因可能为其抗性基因. | 李东良 彭经宙 赵书民 林小钦 杨才生 林华 | 2009 | 世界华人消化杂志2009，17，9： | 3 |
| 16 | 家族不良结局乙型肝炎外周血单个核细胞基因表达谱的建立显示文摘目的应用寡核苷酸基因芯片技术建立家族不良结局乙型肝炎病毒(HBV)感染者外周血单个核细胞的基因表达谱。方法在一个家族不良结局HBV感染家族中,选取患者5例,患者正常配偶4 例,提取外周血单个核细胞RNA,与涵盖2.2万个ESTs的寡核苷酸表达谱基因芯片U133A 2.0杂交,通过Affymetrix扫描仪和DNT分析软件比较患病组与对照组外周血单个核细胞基因表达谱,获得基因的相对表达比值。结果在2.2万个ESTs中初筛出55个差异表达基因,表达上调14个,表达下调41个,差异基因主要(57%)参与免疫反应、细胞信号转导、细胞周期、代谢、细胞凋亡及炎症基因。结论筛选出的55个基因,是宿主感染HBV的差异表达基因,或宿主对HBV的易感基因,为差异表达基因功能研究建立框架,为宿主HBV易感性研究提供新的靶点。 | 赵英仁 何英利 张树林 杨瑗 刘敏 金燕 刘锦锋 | 2005 | 中华肝脏病杂志2005，13，11： | 3 |
| 17 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 18 | 慢性乙型肝炎患者HLADRB1等位基因多态性与干扰素抗病毒治疗应答的相关性研究显示文摘探讨HLA-DRB1等位基因对慢性乙型肝炎α-干扰素抗病毒治疗应答的影响。用序列特异型引物多 聚酶链反应测定山东地区126例慢性乙型肝炎患者和76例对照的HLA-DRB1*03、*07、*09、*12、*15等位基 因。慢乙肝组HIA-DRB1*07等位基因阳性率显著高于正常对照组(P<0.025)。α-干扰素治疗无应答组HLA- DRB1*07阳性率明显高于应答组。在慢性乙型肝炎中HLA-DRB1*07高阳性率与α-干扰素治疗低应答率有密 切的关系。 | 褚瑞海 马立宪 王刚 邵丽华 | 2005 | 临床肝胆病杂志2005，21，5： | 3 |
| 19 | HLA基因与乙型肝炎病毒感染相关性研究进展显示文摘 | 李玮 李建忠 | 2010 | 青岛医药卫生2010，42，6： | 3 |
| 20 | 与乙型肝炎病毒感染相关的易感或拮抗基因的研究进展显示文摘乙型肝炎病毒(HBV)感染是世界范围的严重公共卫生问题之一.HBV感染后,机体对病毒的清除能力以及疾病的进展和不同临床转归,除了与病毒因素和环境因素有关外,在很大程度上取决于个体间基因组的差异.本文就近年来与乙型肝炎病毒感染相关的易感或拮抗基因的研究进展及研究中存在的问题作一综述,主要包括影响机体免疫应答的基因、人类白细胞抗原(HLA)、肿瘤坏死因子(TNF)、白细胞介素(IL)、干扰素(IFN)等,同时对这一领域的研究前景作一展望. | 崔建军 曾争 田国保 田地 陆海英 | 2007 | 世界华人消化杂志2007，15，11： | 3 |
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