共被期刊论文引用了4次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 新型冠状病毒抗体检测及应用显示文摘自2019年12月,由新型冠状病毒(Severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)引起的新型冠状病毒肺炎(coro-na virus disease 2019,COVID-19)迅速在全球暴发,是迄今为止全球最大的公共卫生事件。据世界卫生组织报道,截止2022年2月24日,全球新型冠状病毒肺炎感染人数已达4.2亿,死亡人数超过540万,严重威胁人类生命安全。随着德尔塔(Delta)、奥密克戎(Omicron)等变异毒株及无症状感染者的出现,对疾病的早期诊断及疫情防控工作提出着巨大的挑战。 | 徐婧玥 | 2022 | 华北理工大学学报(医学版)2022，24，4： | 0 |
| 2 | Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses显示文摘A steep rise in Omicron reinfection cases suggests that this variant has increased immune evasion ability.To evaluate its antigenicity relationship with other variants,antisera from guinea pigs immunized with spike protein of SARS-CoV-2 variants of concern(VOCs)and variants of interest(VOIs)were cross-tested against pseudotyped variants.The neutralization activity against Omicron was markedly reduced when other VOCs or VOIs were used as immunogens,and Omicron(BA.1)-elicited sera did not efficiently neutralize the other variants.However,a Beta or Omicron booster,when administered as the 4th dose 3-months after the 3rd dose of any of the variants,could elicit broad neutralizing antibodies against all of the current variants including Omicron BA.1.Further analysis with 280 available antigen–antibody structures and quantification of immune escape from 715 reported neutralizing antibodies provide explanations for the observed differential immunogenicity.Three distinct clades predicted using an in silico algorithm for clustering of sarbecoviruses based on immune escape provide key information for rational design of vaccines. | Qianqian Li Li Zhang Ziteng Liang Nan Wang Shuo Liu Tao Li Yuanling Yu Qianqian Cui Xi Wu Jianhui Nie Jiajing Wu Zhimin Cui Qiong Lu Xiangxi Wang Weijin Huang Youchun Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 3 | A highly immunogenic live-attenuated vaccine candidate prevents SARS-CoV-2 infection and transmission in hamsters显示文摘The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic,urgently requiring effective countermeasures against its rapid expansion.All available vaccine platforms are being used to generate safe and effective COVID-19 vaccines.Here,we generated a live-attenuated candidate vaccine strain by serial passaging of a SARSCoV-2 clinical isolate in Vero cells. | Xiao-Feng Li Zhen Cui Hang Fan Qi Chen Lei Cao Hong-Ying Qiu Na-Na Zhang Yan-Peng Xu Rong-Rong Zhang Chao Zhou Qing Ye Yong-Qiang Deng Yan Guo Si Qin Kaiyue Fan Lei Wang Zijing Jia Yujun Cui Xiangxi Wang Cheng-Feng Qin | 2022 | The Innovation2022，3，2： | 0 |
| 4 | SARS-CoV-2棘突蛋白H146Y突变的逆转录重组酶介导的等温扩增方法建立显示文摘目的基于逆转录重组酶介导的恒温扩增(reverse transcriptional recombinase aided amplification,RT-RAA)技术,建立一种快速,灵敏,简便的SARS-CoV-2棘突蛋白(S)H146Y突变检测方法。方法针对SARS-CoV-2棘突蛋白H146Y突变区域设计RT-RAA特异性引物和荧光探针,使用优化的RT-RAA方法进行恒温扩增检测,评价方法的灵敏度和特异性,并与二代测序技术进行比较。结果基于荧光信号的RT-RAA方法能在39℃,30 min完成检测,SARS-CoV-2 S蛋白H146(S-H146)野生株和Y146(S-Y146)突变株检测限均为10 copies/μL,能够依据荧光值明显区分S-H146毒株与S-Y146毒株的重组质粒或临床样本,且和五种常见呼吸道感染病毒无交叉反应,与二代测序技术方法一致性高。结论建立的RT-RAA荧光检测方法具有灵敏度高,特异性强,适用于SARS-CoV-2 S蛋白H146Y突变株的快速检测,为基层医疗机构提供了新的鉴定方法。 | 郭悦 安柏霖 刘丹丹 罗君红 赵康辰 朱小娟 葛以跃 吴宏斌 崔仑标 | 2022 | 国际病毒学杂志2022，29，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员