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| 1 | 牙髓干细胞多项分化潜能的研究及应用进展显示文摘再生医学通过利用干细胞分化为特定细胞类型的能力来替代和恢复组织功能。干细胞是具有自我更新和无限克隆能力的原始细胞,参与组织发育、维持稳态及组织缺损修复等多种生理过程。牙髓内含有丰富的牙源性成体干细胞即牙髓干细胞(DPSC),其具有增殖活跃和自我更新能力。DPSC具有很强的多谱系分化能力,包括成骨分化、牙源性分化、成脂分化、成软骨分化、神经源性分化等,目前已经广泛应用于组织工程及再生医学领域。 | 夏亮 江文欣 邹多宏 | 2022 | 医学综述2022，28，11： | 0 |
| 2 | 颌骨修复重建的分子调控机制研究进展显示文摘临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以及骨重塑等阶段。骨形态发生蛋白(bone morphogenetic proteins,BMPs)、转化生长因子-β(transforming growth factor beta,TGF-β)、血管内皮生长因子(vascular endothelial-derived growth factor,VEGF)等生长因子在促进颌骨骨再生中发挥着重要的作用。细胞因子如白细胞介素和肿瘤坏死因子在调节炎症反应和骨修复中具有双重作用。近年来,分子生物学研究在颌骨修复重建领域中已经取得了显著进展。组织工程技术在颌骨修复中有着重要的应用,包括干细胞疗法、生物活性支架和生长因子递送系统。但这些治疗手段所涉及的复杂的颌骨修复重建分子调控机制尚不清晰,有待进一步研究。未来的研究方向将集中在精确控制这些分子过程,以及开发更高效的组合治疗策略,以促进颌骨的有效和功能性重建。本综述旨在探讨颌骨修复重建的分子调控机制及其治疗策略的最新进展,为颌骨修复重建的机制提供分子层面的理解。 | 杜信眉 谢静 邹玲 | 2024 | 四川大学学报(医学版)2024，55，1： | 0 |
| 3 | An overview of autophagy in the differentiation of dental stem cells显示文摘Dental stem cells(DSCs)have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response.These properties and their ability to both maintain self-renewal and undergo multi-lineage differentiation establish them as key players in regenerative medicine.While many regulatory factors determine the differentiation trajectory of DSCs,prior research has predominantly been based on genetic,epigenetic,and molecular aspects.Recent evidence suggests that DSC differentiation can also be influenced by autophagy,a highly conserved cellular process responsible for maintaining cellular and tissue homeostasis under various stress conditions.This comprehensive review endeavors to elucidate the intricate regulatory mechanism and relationship between autophagy and DSC differentiation.To achieve this goal,we dissect the intricacies of autophagy and its mechanisms.Subsequently,we elucidate its pivotal roles in impacting DSC differentiation,including osteo/odontogenic,neurogenic,and angiogenic trajectories.Furthermore,we reveal the regulatory factors that govern autophagy in DSC lineage commitment,including scaffold materials,pharmaceutical cues,and the extrinsic milieu.The implications of this review are far-reaching,underpinning the potential to wield autophagy as a regulatory tool to expedite DSC-directed differentiation and thereby promote the application of DSCs within the realm of regenerative medicine. | XITONG ZHAO TIANJUAN JU XINWEI LI CHANGFENG LIU LULU WANG LI-AN WU | 2024 | BIOCELL2024，48，1： | 0 |
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