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| 1 | 血清HMGB1、TLR4在乙肝相关慢加急性肝衰竭中的表达研究显示文摘目的:探讨高迁移率族蛋白B1(HMGB1)及其Toll样受体4(TLR4)在乙肝相关慢加急性肝衰竭中的表达。方法:选取2018年11月至2019年6月我院诊断为乙肝相关慢加急性肝衰竭的72例患者作为实验组;另选取同期在我院诊断为慢性乙型肝炎的30例患者作为慢性乙型肝炎组,选取30例健康查体者作为对照组。所有研究对象于入院后第1天清晨空腹采集外周血液,采用酶联免疫吸附法测定HMGB1、TLR4的含量。结果:实验组血清中HMGB1水平高于其他两组(P<0.05),受体TLR4水平高于其他两组(P<0.05)。结论:HMGB1及其TLR4受体在乙肝相关慢加急性肝衰竭中表达水平增高,HMGB1在慢加急性肝衰竭的发生、发展过程中可能发挥重要作用,HMGB1及其受体TLR4在慢加急性肝衰竭的诊断中有可能作为辅助诊断指标,同时HMGB1可能成为慢加急性肝衰竭治疗的一个潜在靶点。 | 袁宏香 苏建荣 张秋云 赵艳 于艳华 娄金丽 | 2019 | 中国医药导刊2019，21，11： | 9 |
| 2 | 肝癌祖细胞在肝细胞癌发生中作用的研究进展显示文摘肝细胞癌(hepatocellular carcinoma,HCC)是世界范围内最常见的原发性肝恶性肿瘤。当HCC患者出现明显症状时,肿瘤往往已经是中晚期,极大地影响了患者的生存质量。肝癌祖细胞(hepatocellular carcinoma progenitor cell,HcPC)是一种癌前病变中所含有的肿瘤起始细胞,对HcPC的发生机制以及生物学功能进行系统阐述,可能对HCC的早期诊断和干预治疗具有潜在的重要意义。近年来已有大量文献报道HcPC的生物标志物,如CD44、EpCAM、SOX9、OV6以及CK19等在HCC发生中所发挥重要作用,它们表达水平的升高对肝细胞的恶性转化、HcPC干性的维持以及肿瘤细胞的迁移和侵袭均具有一定的促进作用。针对HcPC的研究有望为HCC早期诊断提供新的思路,而通过阻止HcPC向HCC的恶性转化也有望成为一种治疗HCC的新方法。本文尝试对HcPC的发现过程、HcPC的主要来源、现有HcPC相关生物标志物等进行较为系统的综述,期望有助于今后HcPC相关研究的深入开展。 | 张杨倩雯(综述) 王红阳(审阅) 陈磊(审阅) | 2021 | 中国肿瘤生物治疗杂志2021，28，1： | 2 |
| 3 | Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats显示文摘Aristolochic acid I(AAI)is a well-known nephrotoxic carcinogen,which is currently reported to be also associated with hepatocellular carcinoma(HCC).Whether AAI is a direct hepatocarcinogen remains controversial.In this study we investigated the association between AAI exposure and HCC in adult rats using a sensitive rat liver bioassay with several cofactors.Formation of glutathione S-transferase placental form-positive(GST-P^(+))foci was used as the marker for preneoplastic lesions/clonal expansion.We first conducted a medium-term(8 weeks)study to investigate whether AAI had any tumor-initiating or-promoting activity.Then a long-term(52 weeks)study was conducted to determine whether AAI can directly induce HCC.We showed that oral administration of single dose of AAI(20,50,or 100 mg/kg)in combination with partial hepatectomy(PH)to stimulate liver proliferation did not induce typical GST-P^(+)foci in liver.In the 8-week study,only high dose of AAI(10 mg·kg^(−1)·d^(−1),5 days a week for 6 weeks)in combination with PH significantly increased the number and area of GST-P+foci initiated by diethylnitrosamine(DEN)in liver.Similarly,only high dose of AAI(10 mg·kg^(−1)·d^(−1),5 days a week for 52 weeks)in combination with PH significantly increased the number and area of hepatic GST-P^(+)foci in the 52-week study.No any nodules or HCC were observed in liver of any AAI-treated groups.In contrast,long-term administration of AAI(0.1,1,10 mg·kg^(−1)·d^(−1))time-and dose-dependently caused death due to the occurrence of cancers in the forestomach,intestine,and/or kidney.Besides,AAI-DNA adducts accumulated in the forestomach,kidney,and liver in a time-and dose-dependent manner.Taken together,AAI promotes clonal expansion only in the high-dose group but did not induce any nodules or HCC in liver of adult rats till their deaths caused by cancers developed in the forestomach,intestine,and/or kidney.Findings from our animal studies will pave the way for further large-scale epidemiological investigation of the associations between AA and HCC. | Yong-zhen Liu Heng-lei Lu Xin-ming Qi Guo-zhen Xing Xin Wang Pan Yu Lu Liu Fang-fang Yang Xiao-lan Ding Ze-an Zhang Zhong-ping Deng Li-kun Gong Jin Ren | 2021 | Acta Pharmacologica Sinica2021，42，12： | 1 |
| 4 | Network pharmacology-based prediction and verification of the molecular targets and pathways for Piper longum Linn,against liver cancer显示文摘Liver cancer is a common malignant tumor,which is one of the most common causes of cancer related deaths worldwide,specially,in China.Piper longum Linn,is a traditional Chinese medicine that is used to treat and prevent diseases in clinical practice,however,the active ingredients and potential targets of its action against liver cancer remain unclear.In this study,network pharmacology approach was used to identify active ingredients and the major targets of Piper longum against liver cancer.In addition,the key pathways were also predicted on the network pharmacology level,which might be beneficial to the chemical basis and pharmacological studies of this plant. | Liwei Lu Jie Wang Xiaoxiao Huang Shaojiang Song | 2019 | Asian Journal of Traditional Medicines2019，14，4： | 0 |
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