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| 1 | Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review显示文摘Three-dimensional(3D)bioprinting based on traditional 3D printing is an emerging technology that is used to precisely assemble biocompatible materials and cells or bioactive factors into advanced tissue engineering solutions.Similar technology,particularly photo-cured bioprinting strategies,plays an important role in the field of tissue engineering research.The successful implementation of 3D bioprinting is based on the properties of photopolymerized materials.Photocrosslinkable hydrogel is an attractive biomaterial that is polymerized rapidly and enables process control in space and time.Photopolymerization is frequently initiated by ultraviolet(UV)or visible light.However,UV light may cause cell damage and thereby,affect cell viability.Thus,visible light is considered to be more biocompatible than UV light for bioprinting.In this review,we provide an overview of photo curing-based bioprinting technologies,and describe a visible light crosslinkable bioink,including its crosslinking mechanisms,types of visible light initiator,and biomedical applications.We also discuss existing challenges and prospects of visible light-induced 3D bioprinting devices and hydrogels in biomedical areas. | Zizhuo Zheng David Eglin Mauro Alini Geoff RRichards Ling Qin Yuxiao Lai | 2021 | Engineering2021，7，7： | 3 |
| 2 | Rapid assembling organ prototypes with controllable cell-laden multi-scale sheets显示文摘A native organ has heterogeneous structures, sirength, and cell components. It is a big challenge to fabricate organ prototypes with controllable shapes, strength, and cells. Herein, a hybrid method is developed to fabricate organ prototypes with controlled cell deposition by integrating extrusion-based 3D printing, electrospinning, and 3D bioprinting. Multi-scale sheets were first fabricated by 3D printing and electrospinning;then, all the sheets were assembled into organ prototypes by sol-gel react io n duri ng bioprinting. With this method, macroscale structures fabricated by 3D printing ensure the customized structures and provide mechanical support, nanoscale structures fabricated by electrospinning offer a favorable environment for cell growth, and different types of cells with controllable densities are deposited in accurate locations by bioprinting. The results show that L929 mouse fibroblasts encapsulated in the structures exhibited over 90% survival within 10 days and maintai ned a high proliferation rate. Furthermore, the cells grew in spherical shapes first and then migrated to the nano scale fibers showing stretched morphology. Additionally, a branched vascular structure was successfully fabricated using the presented method. Compared with other methods, this strategy offers an easy way to simultancously realize the shape control, nanolibrous structures, and cell accurate deposition, which will have potemidi applications in tissue cngineering. | Qing Gao Peng Zhao Ruijian Zhou Peng Wang Jianzhong Fu Yong He | 2019 | Bio-Design and Manufacturing2019，2，1： | 2 |
| 3 | 干细胞在颅骨缺损修补中的应用及研究进展显示文摘颅骨缺损是神经外科中常见且重要的临床问题,利用干细胞的成骨特性来修补临界大小的骨缺损已成为人们关注的焦点。目前,各种干细胞在骨组织工程中的应用方面取得了显著进展,但如何提高干细胞的植入率和存活率是该修补方式的关键。干细胞治疗颅骨缺损已经在动物研究中被证明是可行的,这可能为进一步的临床研究开辟新的途径。干细胞移植仍是颅骨缺损修补方式中最有希望的一种。 | 曹志威 邵国 赵志军 张春阳 | 2022 | 实用医学杂志2022，38，3： | 1 |
| 4 | Recent Progress in the Biological Basis of Remodeling Tissue Regeneration Using Nanofibers:Role of Mesenchymal Stem Cells and Biological Molecules显示文摘Opening up new and unlimited avenues in the biomedical field,tissue engineering and regenerative medicine,the electrospinning process is considered as a versatile and the most preferred technique for the fabrication of nanofibers.These tailor-designed nanofibers provide a desirable and bio-inspired physiological niche to cells for better attachment and subsequent proliferation.In this review,an attempt is made to explain the importance of various topological and morphological parameters of nanofibrous scaffolds for efficient bio-mimicking.Some novel approaches(e.g.,appropriate functionalization and extracellular matrix derived from decellularization)utilized for better mimicking and exponential growth of regenerating tissues are also discussed.Furthermore,this review highlights the important parameters necessary for the attachment,proliferation and differentiation of the mesenchymal stem cells for tissue regeneration.The importance of growth factors and their role after introducing the electrospinning techniques for efficient delivery and their role in the proliferation of mesenchymal stem cells in the different specific lineage(e.g.,tenogenic,chondrogenic,neurogenic and osteogenic differentiation)are discussed. | Roqia Ashraf Hasham S.Sofi Hern Kim Faheem A.Sheikh | 2019 | Journal of Bionic Engineering2019，16，2： | 0 |
| 5 | 3D生物打印制备组织工程支架的研究进展显示文摘为进一步推动3D生物打印技术在组织工程支架领域的应用,从当前3D生物打印方法的优劣及相关材料的固化成形机制出发,详细综述了国内外3D生物打印制备组织工程支架的研究进展。针对3D生物打印技术,主要介绍了喷墨、挤出、激光辅助和立体光刻等技术的原理、过程和优缺点;针对3D生物打印材料,主要介绍了聚合物和生物陶瓷等材料的特性、固化成形机制和适应范围;针对3D生物打印应用,主要介绍了3D生物打印在血管、骨、耳、心脏等功能性组织构建中的最新研究进展,指出生物墨水的开发及临床应用是其未来的发展方向。为进一步推动组织工程用3D生物打印技术的发展提供理论与实践参考。 | 王曙东 马倩 王可 谷元慧 | 2023 | 纺织学报2023，44，3： | 0 |
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