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| 1 | Resting-state network complexity and magnitude changes in neonates with severe hypoxic ischemic encephalopathy显示文摘Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800016409) and the protocol version is 1.0. | Hong-Xin Li Min Yu Ai-Bin Zheng Qin-Fen Zhang Guo-Wei Hua Wen-Juan Tu Li-Chi Zhang | 2019 | Neural Regeneration Research2019，14，4： | 4 |
| 2 | New era of treatment and evaluation of traumatic brain injury and spinal cord injury显示文摘Traumatic brain injury(TBI)and spinal cord injury(SCI)are leading causes of death and disability worldwide(Center for Disease Control,2006).Both injuries are induced by external traumatic event and likely happen together.After the primary traumatic incident,the secondary injury,including ischemic,inflammatory,metabolic and biochemical cascades,is likely more devastating(Blumbergs,1997).To date,all clinical trials have failed to cure TBI and SCI,due to | Zhifeng Kou Dong Sun | 2016 | Neural Regeneration Research2016，11，1： | 1 |
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