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| 1 | 桦褐孔菌化学成分和药理作用研究进展显示文摘桦褐孔菌是一种药食两用的真菌,近年来,其在治疗糖尿病、恶性肿瘤及艾滋病等方面的突出作用吸引了国内外学者关注。药理学研究表明桦褐孔菌具有调节血糖、血脂和免疫功能、抗肿瘤、抗炎、抗衰老等方面的活性,而且还能够调节血压及胃肠道机能。本文对近年来国内外研究桦褐孔菌的药理活性及毒理学作用方面进行了系统综述,以期为深入研究其活性物质、提升药用价值及综合开发利用并被西方认可中医药提供科学依据。 | 崔杰 于新 王立勋 刘艳 吕邵娃 | 2017 | 河北中医药学报2017，32，3： | 18 |
| 2 | 桦褐孔菌提取物体外抗肿瘤活性及对细胞周期的影响显示文摘目的研究桦褐孔菌提取物的抗肿瘤活性及对人乳腺癌MCF-7细胞周期的影响及其可能机制。方法使用细胞计数试剂盒(cell counting kit-8,CCK-8)检测桦褐孔菌提取物对HepG2、A549、SGC-7901、HeLa和MCF-7细胞增殖的抑制作用并计算半数抑制浓度(half maximal inhibitory concentration,IC50);选择抑制效果最好的MCF-7细胞株,观察其作用后细胞的形态学改变、细胞凋亡率和细胞周期的变化;并通过Western Blot实验检测细胞周期相关蛋白Cyclin D1、CDK4、PCNA和NUSAP1的表达。结果桦褐孔菌提取物可有效抑制HepG2、A549、SGC-7901、HeLa和MCF-7细胞增殖,作用48 h后的IC50分别为2.34、3.71、2.24、2.27、0.59 mg/ml;桦褐孔菌提取物可引起MCF-7细胞显著的形态学改变;可诱导MCF-7细胞凋亡,与对照组相比,差异有统计学意义(P<0.05或P<0.01);并明显影响MCF-7细胞的细胞周期分布,使细胞阻滞于S期(P<0.01);桦褐孔菌提取物可抑制MCF-7细胞中Cyclin D1、CDK4、PCNA、NUSAP1蛋白的表达,与对照组比较,差异均有统计学意义(P<0.05)。结论桦褐孔菌提取物可抑制多种组织来源的肿瘤细胞增殖,其中对MCF-7细胞抑制效果最好,可以诱导细胞凋亡,阻滞细胞周期达到抗肿瘤作用,可能是通过下调Cyclin D1、CDK4、PCNA和NUSAP1的蛋白表达来调控细胞周期,从而抑制肿瘤细胞过度增殖。本实验为桦褐孔菌提取物的药用开发提供新的方法和思路。 | 石丽丽 韩超 赵金鹏 杨倬 李岩 霍军生 | 2020 | 实用预防医学2020，27，8： | 2 |
| 3 | 桦褐孔菌降脂活性成分及作用机制研究进展显示文摘桦褐孔菌[Inonotus obliquus(Fr.)Pilat]是一种天然真菌药物,活性成分丰富,本综述对其主要活性成分诸如多糖、黄酮、多酚和三萜以及它们的降脂机制进行综述,以期为新型无毒副作用的降脂药物的开发提供新思路。 | 隆海鸣 李鑫 | 2022 | 特产研究2022，44，3： | 1 |
| 4 | Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone显示文摘Our previous finding demonstrated that chronic corticosterone(CORT)may be involved in mediating the pathophysiology of premature aging in rats.Frequent jet lag increases the risk for many diseases,including obesity and type 2 diabetes,and is associated with the aging processes.However,the effect of jet lag on CORT-induced depression and its association with aging phenotypes remain unclear.In this study,the rats were exposed to both CORT and jet lag treatment,and the differences were analyzed and compared to rats with single CORT treatment.Our results showed that jet lag treatment aggravated CORT-induced depression-like behavior evidenced by sucrose intake test,forced swimming test,and open field test.Additionally,this treatment aggravated the shortening of telomeres,which possibly resulted in decreased telomerase activity,and downregulated the expression of telomere-binding factor 2(TRF2)and telomerase reverse transcriptase compared to that in CORT rats,as revealed by quantitative real-time-polymerase chain reaction and western blot analysis,respectively.The shortening of telomeres may have been caused by increased oxidative stress,which was associated with the inhibition of sirtuin 3.Exposure to jet lag also aggravated the degeneration of mitochondrial functions,as shown by the decreases in the mRNA expression of COX1,ND1,and Tfam.Our findings provide physiological evidence that jet lag exposure may worsen stress-induced depression and age-related abnormalities. | Qichen Shen Junli Wu Yuehan Ni Xiaoxian Xie Chunan Yu Qingfeng Xiao Jiafeng Zhou Xia Wang Zhengwei Fu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 0 |
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