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| 1 | DNA损伤响应信号通路与蛋白质翻译后修饰显示文摘DNA损伤响应涉及到损伤的感应、信号的传递、DNA修复等一系列通路和过程。在这些过程中,有大量蛋白质以其不同的修饰状态参与其中。有些蛋白质的修饰参与信号的识别和传递;有些修饰改变酶的活性;而有些修饰则参与调节,有大量的研究者对参与DNA损伤相关蛋白的功能及修饰进行了研究。它们在DNA损伤响应分别发挥着不同的功能,其协同作用使细胞得以从细胞周期关卡中恢复,进入正常周期。有大量研究者对参与DNA损伤相关蛋白的功能及其修饰进行了研究。在本综述中我们将从DDR所涉及的信号通路角度,主要对DDR及DNA损伤修复途径中所涉及到的蛋白质及其修饰进行总结。 | 杜珊珊 张宇星 王全会 | 2017 | 生命的化学2017，37，1： | 2 |
| 2 | Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment显示文摘More and more in-depth studies have revealed that the occurrente and development of tumors depend on gene mutation and tumor heterogeneity.The most important manifestation of tumor heterogeneity is the dynamic change of tumor microenvironment(TME)heterogeneity.This depends not only on the tumor cells themselves in the microenvironment where the infiltrating immune cells and matrix together forming an antitumor and/or pro-tumor network.TME has resulted in novel therapeutic in terve ntions as a place beyond tumor beds.The malig nant can cer cells,tumor in filtrate immune cells,angiogenic vascular cells,lymphatic endothelial cells,cancer-associated fibroblastic cells,and the released factors including intracellular metabolites,hormonal signals and inflammatory mediators all contribute actively to cancer progression.Protein post-translational modification(PTM)is often regarded as a degradative mechanism in protein destruction or turnover to maintain physiological homeostasis.Advances in quantitative transcriptomics,proteomics,and nuclease-based gene editing are now paving the global ways for exploring PTMs.In this review,we focus on recent developments in the PTM area and speculate on their importanee as a critical functional readout for the regulation of TME.A wealth of information has been emerging to prove useful in the search for conventional therapies and the development of global therapeutic strategies. | Wen Li Feifei Li Xia Zhang Huikuan Lin Chuan Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 3 | 衰老过程中的表观遗传调控显示文摘生物体衰老表现为性成熟后生理功能的逐渐衰退,最终引发疾病和死亡。表观遗传调控的紊乱作为衰老的一个重要特征,暗示可以通过干预表观遗传调控来延缓衰老并治疗衰老相关疾病。现就衰老过程中的表观遗传调控的最新进展作一综述。 | 豆晓阳 玄鸿文 穆永林 韩敬东 | 2017 | 生命科学2017，29，10： | 0 |
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