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| 1 | The role of circulating miRNAs in multiple myeloma显示文摘Multiple myeloma(MM) is a common malignant hematological disease. Dysregulation of micro RNAs(mi RNAs) in MM cells and bone marrow microenviroment has important impacts on the initiation and progression of MM and drug resistance in MM cells. Recently, it was reported that MM patient serum and plasma contained sufficiently stable mi RNA signatures, and circulating mi RNAs could be identified and measured accurately from body fluid. Compared to conventional diagnostic parameters, the circulating mi RNA profile is appropriate for the diagnosis of MM and estimates patient progression and therapeutic outcome with higher specificity and sensitivity. In this review, we mainly focus on the potential of circulating mi RNAs as diagnostic, prognostic, and predictive biomarkers for MM and summarize the general strategies and methodologies for identification and measurement of circulating mi RNAs in various cancers. Furthermore, we discuss the correlation between circulating mi RNAs and the cytogenetic abnormalities and biochemical parameters assessed in multiple myeloma. | ZHANG Ji XIAO XiaoJuan LIU Jing | 2015 | Science China(Life Sciences)2015，58，12： | 4 |
| 2 | 脉冲免疫控制肿瘤生长模型的动力学性质显示文摘本文建立了一个具周期脉冲免疫控制肿瘤生长的微分方程模型,主要用来描述在固定时间段、瞬时注入的免疫效应细胞对肿瘤生长的影响.运用脉冲微分方程的比较定理和Floquet乘子理论,分析了模型的动力学性质,得到解的有界性与无肿瘤周期解的存在条件,数值模拟支持所得到的理论结果.最后,在数值上比较了常值输入和脉冲输入免疫效应细胞的疗效,展示了后者在控制肿瘤细胞生长方面具有优势. | 王晶囡 杨占文 吕静 蒋卫华 张艳桥 | 2016 | 生物数学学报2016，31，3： | 1 |
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