共被期刊论文引用了2次
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| 1 | rAAV/ABAD-DP-6His attenuates oxidative stressinduced injury of PC12 cells显示文摘Our previous studies have revealed that amyloid β(Aβ)-binding alcohol dehydrogenase(ABAD) decoy peptide antagonizes Aβ42-induced neurotoxicity. However, whether it improves oxidative stress injury remains unclear. In this study, a recombinant adenovirus constitutively secreting and expressing Aβ-ABAD decoy peptide(rAAV/ABAD-DP-6His) was successfully constructed. Our results showed that rAAV/ABAD-DP-6His increased superoxide dismutase activity in hydrogen peroxide-induced oxidative stress-mediated injury of PC12 cells. Moreover, rAAV/ABADDP-6His decreased malondialdehyde content, intracellular Ca2+ concentration, and the level of reactive oxygen species. rAAV/ABAD-DP-6His maintained the stability of the mitochondrial membrane potential. In addition, the ATP level remained constant, and apoptosis was reduced. Overall, the results indicate that rAAV/ABAD-DP-6His generates the fusion peptide, Aβ-ABAD decoy peptide, which effectively protects PC12 cells from oxidative stress injury induced by hydrogen peroxide, thus exerting neuroprotective effects. | Mingyue Jia Mingyu Wang Yi Yang Yixin Chen Dujuan Liu Xu Wang Lei Song Jiang Wu Yu Yang | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 2 | 以β-淀粉样蛋白为靶点的阿尔茨海默病治疗途径显示文摘阿尔茨海默病(AD)的病因有很多,有研究证明β淀粉样蛋白(Aβ)在脑内的沉积是AD病理的始发因素和重要环节,是导致AD的关键因素。以Aβ为靶点治疗AD是新突破点。 | 樊星 陈红 高雪峰 赵鹏 董贵成 | 2016 | 中西医结合心血管病电子杂志2016，4，36： | 1 |
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