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| 1 | Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia显示文摘Resveratrol possesses beneficial biological effects,which include anti-oxidant,anti-inflammatory and anti-carcinogenic properties.Recently,resveratrol has been shown to exhibit neuroprotective effects in models of Parkinson's disease,cerebral ischemia and Alzheimer's disease.However,its effects on vascular dementia remain unclear.The present study established a rat model of vascular dementia using permanent bilateral common carotid artery occlusion.At 8-12 weeks after model induction,rats were intragastrically administered 25 mg/kg resveratrol daily.Our results found that resveratrol shortened the escape latency and escape distances in the Morris water maze,and prolonged the time spent percentage and swimming distance percentage in the target quadrant during the probe test,indicating that resveratrol improved learning and memory ability in vascular dementia rats.Further experiments found that resveratrol decreased malonyldialdehyde levels,and increased superoxide dismutase activity and glutathione levels in the hippocampus and cerebral cortex of vascular dementia rats.These results confirmed that the neuroprotective effects of resveratrol on vascular dementia were associated with its anti-oxidant properties. | Xingrong Ma Zhikun Sun Yanru Liu Yanjie Jia Boai Zhang Jiewen Zhang | 2013 | Neural Regeneration Research2013，8，22： | 7 |
| 2 | 低氧预适应对小鼠急性脑梗死缺血半暗带神经元凋亡的影响及机制研究显示文摘目的探讨低氧预适应对小鼠急性脑梗死缺血半暗带神经元凋亡的影响,并对相关凋亡机制进行研究。方法将Blb/c近交系小鼠按照随机数字表法分为(1)正常对照组(N),无任何处理;(2)假手术组(C),仅行冷光源照射,不注射玫瑰红;(3)急性脑梗死组(CI),光化学法诱导小鼠脑皮质梗死模型;(4)低氧预适应+急性脑梗死组(HP+CI),低氧预适应后复制光化学法诱导小鼠脑皮质梗死模型。应用免疫荧光、激光共聚焦等技术检测模型制作成功后24h脑内缺血半暗带区细胞凋亡、Bcl-2、Bax和Caspase-3表达变化。结果 N组、C组小鼠大脑皮质偶见TUNEL阳性细胞,CI组和HP+CI组阳性细胞数明显增多,其中HP+CI组较CI组减少,差异有统计学意义(P<0.01)。CI组和HP+CI组的Bcl-2表达均分别非常显著地高于N组、C组,HP+CI组又显著地高于CI组。CI组和HP+CI组Bax的表达均分别非常显著地高于N组、C组,HP+CI组却非常显著地低于CI组。CI组和HP+CI组Caspase-3的表达均分别非常显著地高于N组、C组,但HP+CI组却非常显著地低于CI组。结论低氧预适应通过Bcl-2的高表达、Bax低表达和Caspase-3的低表达,抵御急性脑梗死缺血半暗带神经元凋亡,参与脑梗死保护机制。 | 赵丽红 林立文 张颜波 | 2013 | 中风与神经疾病杂志2013，30，9： | 1 |
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