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| 1 | OTSC金属夹系统在消化道内镜治疗中的应用显示文摘目的评估OTSC金属夹系统对消化道穿孔、瘘及出血等临床应用的有效性及安全性。方法对我科2014年8月至2016年9月收治的33例使用OTSC金属夹的患者的临床资料进行回顾性分析。其中14例为消化道出血,8例为术后瘘,11例为胃、十二指肠球部固有肌层占位全层切除术中穿孔。对33例患者使用OTSC金属夹系统治疗的技术成功率、临床成功率及手术并发症进行相关统计。结果 33例患者技术成功率为96.97%,临床成功率为93.94%,术中未出现相关并发症。其中,消化道出血患者中13例成功止血,临床成功率达92.85%;术后吻合口瘘的患者中6例行OTSC成功封堵,成功率75.00%;11例全层切除后导致穿孔的患者行OTSC缝合,临床成功率为100%。结论 OTSC作为临床一种新型的内镜下缝合系统,对于消化道出血、穿孔及瘘等疾病的治疗是安全、有效的。 | 彭学 谢霞 樊超强 柏健鹰 | 2017 | 局解手术学杂志2017，26，1： | 19 |
| 2 | 双臂钳联合尼龙绳技术闭合急性胃穿孔可行性及初步疗效的动物实验研究显示文摘目的初步探讨钳式双臂抓取器(简称双臂钳)联合尼龙绳技术闭合急性胃穿孔的可行性及疗效。方法实验猪2只,在双孔道内镜下应用双臂钳联合尼龙绳技术闭合急性胃穿孔,术后观察存活情况,后解剖观察穿孔部位的闭合情况。结果实验术后观察1周,期间有轻度感染,1周后剖腹检查发现腹腔轻度粘连,穿孔部位尼龙绳脱落,可见溃疡样缺损,亚甲蓝测漏试验阴性,组织学检查见肉芽组织连接胃穿孔部位,有慢性炎细胞浸润及纤维组织增生,再生黏膜向穿孔中心爬行。结论双臂钳联合尼龙绳闭合急性胃穿孔技术可行,疗效确切。 | 董芳芬 何颖颖 陈予真 林楷 宋泽宇 许亮亮 谢招飞 施宏 | 2017 | 中华消化内镜杂志2017，34，5： | 11 |
| 3 | 消化道痿内镜处理的临床研究显示文摘目的评估内镜下空肠管置入术、钛夹夹闭术及耙状金属夹系统(OTSC)对消化道瘘治疗的应用价值。方法回顾性分析2015年7月至2017年7月苏州大学附属第一医院收治的38例消化道瘘患者资料,其中单纯行内镜下空肠管置入术(空肠管组)13例,行内镜下钛夹夹闭术(钛夹组)20例,OTSC闭合(OTSC组)5例。对患者的技术成功率、临床治愈率及术后住院时间进行统计分析。结果所有患者顺利完成了内镜下治疗,治疗过程中未出现内镜操作相关并发症。空肠管组4例瘘口完全愈合,3例瘘口较前缩小,5例瘘口未见明显变化,1例死亡,完全治愈率30.8%(4/13);患者术后住院(47.4±14.1)d。钛夹组16例瘘口完全愈合,3例瘘口未见缩小,1例死亡,完全治愈率80.0%(16/20);术后住院(17.9±8.9)d。OTSC组5例患者均完全治愈,完全治愈率100.0%(5/5)。其中1例难治性食管瘘患者采用多次OTSC联合钛夹夹闭的方式逐步缩小瘘口直至完全愈合,瘘口愈合时长为102d,剩余4例患者采用单纯OTSC治疗,术后住院(5.3±1.7)d。OTSC组与钛夹组及空肠管组相比较,其瘘口完全愈合率更高(P=0.03,P<0.001),术后住院时长更短(P=0.04,P<0.001)。结论内镜下微创技术可有效治疗消化道瘘,且具有创伤小、操作简便、愈合快、安全等优点,值得临床推广。 | 张幸 周书成 史冬涛 张德庆 李锐 陈卫昌 | 2019 | 中华消化内镜杂志2019，36，2： | 9 |
| 4 | Role of over the scope clips in the management of iatrogenic gastrointestinal perforations显示文摘Advances in endoscopic and surgical techniques have increased the frequency and complexity of these procedures and associated complications such as gastrointestinal perforation. With the advancements in the field of gastroenterology, the promising use of an over the scope clips(OTSC) has fulfilled the unmet need for a reliable endoscopic devise in approximation of gastrointestinal perforation. This novel approach has raised the level of confidence in endoscopist in dealing with this serious complication during endoscopy. Here we have shared our experience with OTSC to evaluate its efficacy and safety in managing iatrogenic gastrointestinal perforations during endoscopy. | Kinesh Changela Muhhamad A Virk Niravkumar Patel Sushil Duddempudi Mahesh Krishnaiah Sury Anand | 2014 | World Journal of Gastroenterology2014，20，32： | 7 |
| 5 | OTSC治疗难治性消化道瘘的应用评价显示文摘目的探讨Over-The-Scope-Clip system(OTSC)治疗难治性消化道瘘的应用价值。方法收集2018年11月至2021年12月于中国人民解放军总医院第七医学中心接受内镜下OTSC治疗的12例难治性消化道瘘患者临床资料,评价OTSC疗效。结果12例难治性消化道瘘患者共17处病变,包括食管气管瘘5例,食管纵隔瘘、食管胃吻合口瘘、食管小肠吻合口瘘、十二指肠瘘各1例,直肠阴道瘘2例、直肠吻合口瘘1例,男6例,女6例,年龄(52.2±14.7)岁(23~75岁)。瘘口形成时间为(6.3±6.7)个月(1~24个月);瘘口边缘全瘢痕占比83.3%;瘘口黏膜厚度(0.5±0.1)cm(0.2~0.8 cm);瘘口直径(0.6±0.6)cm(0.3~2.5 cm),其中<1.0 cm 8例、1.0~2.0 cm 3例、>2.0 cm 1例。术后随访,7例实现黏膜愈合,2例因瘘口未愈合追加外科手术,2例置入食管支架,1例自行愈合;OTSC治疗成功率为58.3%。进一步分析临床特征,OTSC操作成功率在直肠瘘中显著低于非直肠瘘,差异有统计学意义(0 vs 77.8%,P=0.045);失败组OTSC操作时间显著长于成功组,差异有统计学意义[(15.0±4.9)min vs(7.9±5.4)min,U=4.00,P=0.03]。结论OTSC是治疗难治性消化道瘘的有效方法,但需进一步掌握适应证、控制操作时间。 | 谢惠 李娜 余东亮 尹馥梅 何玉琦 金鹏 盛剑秋 王昕 | 2022 | 胃肠病学和肝病学杂志2022，31，3： | 2 |
| 6 | Ischemic colitis after enema administration: Incidence, timing, and clinical features显示文摘BACKGROUND Enema administration is a common procedure in the emergency department(ED). However, several published case reports on enema-related ischemic colitis(IC) have raised the concerns regarding the safety of enema agents. Nevertheless, information on its true incidence and characteristics are still lacking.AIM To investigate the incidence, timing, and risk factors of IC in patients receiving enema.METHODS We consecutively collected the data of all adult patients receiving various enema administrations in the ED from January 2010 to December 2018 and identified patients confirmed with IC following enema. Of 8320 patients receiving glycerin enema, 19 diagnosed of IC were compared with an age-matched control group without IC.RESULTS The incidence of IC was 0.23% among 8320 patients receiving glycerin enema;however, there was no occurrence of IC among those who used other enema agents. The mean age ± standard deviation(SD) of patients with glycerin enemarelated IC was 70.2 ± 11.7. The mean time interval ± SD from glycerin enema administration to IC occurrence was 5.5 h ± 3.9 h(range 1-15 h). Of the 19 glycerin enema-related IC cases, 15(79.0%) were diagnosed within 8 h. The independent risk factors for glycerin-related IC were the constipation score [Odds ratio(OR), 2.0;95% confidence interval(CI): 1.1-3.5, P = 0.017] and leukocytosis(OR, 4.5;95%CI: 1.4-14.7, P = 0.012).CONCLUSION The incidence of glycerin enema-related IC was 0.23% and occurred mostly in the elderly in the early period following enema administration. Glycerin enemarelated IC was associated with the constipation score and leukocytosis. | Yura Ahn Gil-Sun Hong Ju Hee Lee Choong Wook Lee Seon-Ok Kim | 2020 | World Journal of Gastroenterology2020，26，41： | 2 |
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