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| 1 | 丝胶蛋白的生物活性及应用研究进展显示文摘家蚕丝胶蛋白是一种天然高分子蛋白,资源丰富。丝胶蛋白不仅具有抗氧化、抑菌等一系列独特的生物学性能,还具有良好的生物相容性和荧光性,含有大量便于交联和修饰的氨基、羟基、羧基等活性基团,是一种优异的天然生物材料。本文阐述了丝胶蛋白的组成,系统综述了近年来有关丝胶蛋白生物活性和应用方面的研究成果,对丝胶蛋白的应用进行了展望。 | 赵玉瑛 江茹兰 张业顺 方瑷 张国政 | 2019 | 蚕业科学2019，45，5： | 7 |
| 2 | Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis显示文摘Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats. | Zhihong Chen Songhe Yang Yaqiang He Chengjun Song Yongping Liu | 2013 | Neural Regeneration Research2013，8，19： | 2 |
| 3 | Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells显示文摘Sericin from discarded silkworm cocoons of silk reeling has been used in different fields,such as cosmetology,skin care,nutrition,and oncology.The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose (25 mg/kg) streptozotocin.After intragastrical perfusion of sericin for 35 days,blood glucose levels significantly declined,and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased.However,the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats.These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells,and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells. | Chengjun Song Zhenjun Yang Meirong Zhong Zhihong Chen | 2013 | Neural Regeneration Research2013，8，6： | 2 |
| 4 | 丝胶对Ⅱ型糖尿病大鼠海马生长激素/胰岛素样生长因子-1轴的作用显示文摘目的:探讨丝胶对Ⅱ型糖尿病大鼠海马生长激素(GH)/胰岛素样生长因子-1(IGF-1)轴的作用。方法:雄性SD大鼠随机分为正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组。2%链脲佐菌素3d连续腹腔注射的方法建立Ⅱ型糖尿病大鼠模型后,丝胶治疗组和阳性对照组大鼠分别给予丝胶和二甲双胍灌胃治疗35d。ELISA法检测各组大鼠血清GH和IGF-1水平,免疫印迹和RT-PCR法分别检测大鼠海马GH、生长激素受体(GHR)和IGF-1蛋白和mRNA的表达。结果:与正常对照组大鼠比较,糖尿病模型大鼠血清GH水平、海马GH的表达明显升高,血清IGF-1水平、海马GHR和IGF-1的表达明显降低;与糖尿病模型组大鼠比较,丝胶治疗组大鼠血清GH水平、海马GH的表达明显降低,血清IGF-1水平、海马GHR和IGF-1的表达明显升高。结论:丝胶可通过调节糖尿病海马GH/IGF-1轴的异常变化减轻海马损伤。 | 和亚强 王小杰 苏哲君 陈志宏 | 2013 | 解剖学杂志2013，36，3： | 0 |
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