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| 1 | 舒郁散治疗抑郁症临床研究显示文摘目的观察舒郁散治疗抑郁症的临床疗效和安全性,评价其在抑郁症治疗中的作用。方法将187例抑郁症患者随机分为治疗组、西药对照组及中药对照组。治疗组服用舒郁散中药煎剂,每日1剂,分早晚2次口服;西药对照组服用盐酸氟西汀分散片(百忧解),20 mg/d,晨起口服;中药对照组服用中药煎剂加味逍遥散,每日1剂,分早晚2次口服。3组疗程均为6周。观察3组治疗前后中医证候积分、汉密顿抑郁量表(HAMD)评分、抑郁自评量表(SDS)评分及副反应量表(TESS)评分。结果治疗组和西药对照组治疗后中医证候、HAMD、SDS评分与治疗前相比均有明显改善,差异具有统计学意义(P<0.05);2组比较差异无统计学意义(P>0.05)。但治疗组不良反应明显小于西药对照组,差异具有统计学意义(P<0.05)。结论舒郁散能改善抑郁症患者的中医证候及HAMD、SDS评分,且不良反应少,是治疗抑郁症的有效方剂。 | 孙志高 黄泉智 冯杰 陈利平 | 2012 | 中国中医药信息杂志2012，19，12： | 6 |
| 2 | Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment显示文摘The Chinese herb Shuyusan,whose main constituent is jasminoidin,has been shown to protect SH-SY5Y cells against corticosterone-induced damage.SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum.Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells,reduced Bax expression,increased Bcl-2 expression,markedly elevated brain-derived neurotrophic factor mRNA expression,and blocked cell apoptosis.Moreover,the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable.Therefore,Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor.Moreover,high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment. | Liping Chen Zhigao Sun Fawei Wang Chengyong Xu Miao Geng Hongyan Chen Dongmei Duan | 2013 | Neural Regeneration Research2013，8，22： | 1 |
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