| 1 | In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of India显示文摘Objective:To identify the in vitro antiplasmodial activity of seaweed plants against Plasmodium falciparum strains.Methods:A total of eight seaweeds were collecled from Kanvakumari district,Tainilnadu,India.The in vitro antiplasmodial activity was performed in 96 well plates against Plasmodium falciparum,and preliminary phytochemcial analysis were performed for the extracts.Results:Of the selected plants Enteromorpha intestinalis(2.61%) showed maximum percentage of extraction.The minimum concentration of inhibitory(IC50) value was observed with Chaetomorpha antennina[(26.37±4.14)μg/ml.]further,the positive controls such as chloroquine and artemether showed antiplasmodial activities(IC50) with(19.10±5.93) and(6.03±0.21)μg/mL concentrations,respectively.The preliminary phytochemical analysis of the seaweed extracts showed a variety of phytochemical constituents such as carboxylic acids,phenols,protein, resins,steroids and sugars.Conclusions:The antiplasmodial activity of the seaweed extract might due to the presence of sugars and phenolic compounds.From the present findings,it is concluded that,the seaweed extract of Chaetomorpha antennina can be further used as a putative antiplasmodial drugs in near future. | S Ravikumar G Ramanathan M Gnanadesigan A Ramu V Vijayakumar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 0 |
| 2 | 腰骨藤的植物化学和药理学研究进展(英文)显示文摘Ichnocarpus frutescens R. Br. (Apocynaceae), is a woody climbing shrub, found almost in all parts of India. In India, tribes used this plant as a substitute of Indian Sarsaparilla (Hemidesmus indicus) for the treatment of atrophy, convulsions, cough, delirium, dysentery, measles, splenomegaly, tuberculosis, tumor, diabetes as a lactogogue, antipyretic, demulcent, diaphoretic and in skin diseases. Phytochemical investigations indicate that 28 compounds reported from the plant belong to various chemical category viz. phytosterol, triterpenes, flavonoids and various other phenolic compounds. Pharmacological activities of different parts of the plant reported include antiurolithiatic, hepatoprotective, antioxidant, analgesic, antipyretic, anti-inflammatory, antidiabetic, antihyperlipi-demic and antitumor activity. In the present review the literature data on the phytochemical and biological investigations on the I. frutescens are summarized up to March 2011. | Narendra Kumar Singh V. P. Singh | 2012 | 中国天然药物2012，10，4： | 0 |
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