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| 1 | Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction显示文摘The present study established a mouse model of cerebral infarction by middle cerebral artery occlusion,and monitored the effect of 25 μg/kg leukemia inhibitory factor and(or) basic fibroblast growth factor administration 2 hours after model establishment.Results showed that following administration,the number of endogenous neural stem cells in the infarct area significantly increased,malondialdehyde content in brain tissue homogenates significantly decreased,nitric oxide content,glutathione peroxidase and superoxide dismutase activity significantly elevated,and mouse motor function significantly improved as confirmed by the rotarod and bar grab tests.In particular,the effect of leukemia inhibitory factor in combination with basic fibroblast growth factor was the most significant.Results indicate that leukemia inhibitory factor and basic fibroblast growth factor can improve the microenvironment after cerebral infarction by altering free radical levels,improving the quantity of endogenous neural stem cells,and promoting neurological function of mice with cerebral infarction. | Weihui Huang Yadan Li Yufeng Lin Xue Ye Dawei Zang | 2012 | Neural Regeneration Research2012，7，19： | 2 |
| 2 | 白血病抑制因子与干细胞研究进展显示文摘白血病抑制因子(Leukemia inhibitory factor,LIF)是由Tomida于1984年研究鼠骨髓样白血病M1细胞时发现的,它对鼠骨髓样白血病细胞具有抑制作用,故根据其功能而得名。 | 杨恩 刘铭 | 2011 | 现代临床医学2011，37，1： | 1 |
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