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| 1 | Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids显示文摘Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer(PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers are urgently needed in all phases of management from early detection to staging, treatment monitoring, and prognosis. In the blood of patients with cancer, circulating tumor cells(CTCs) and cell-free nucleic acids(cf NAs), such as DNA, m RNA, and noncoding RNA have been recognized. In the recent years, their presence in the blood has encouraged researchers to investigate their potential use as novel blood biomarkers, and numerous studies have demonstrated their potential clinical utility as a biomarker for certain types of cancer. This concept, called 'liquid biopsy' has been focused on as a less invasive, alternative approach to cancer tissue biopsy for obtaining genetic and epigenetic aberrations that contribute to oncogenesis and cancer progression. In this article, we review the available literature on CTCs and cfN As in patients with cancer, particularly focusing on PCa, and discuss future perspectives in this field. | Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Tsutomu Kawaguchi Mahito Miyamae Wataru Okajima Takuma Ohashi Tomohiro Arita Hirotaka Konishi Atsushi Shiozaki Ryo Morimura Hisashi Ikoma Kazuma Okamoto Eigo Otsuji | 2016 | World Journal of Gastroenterology2016，22，25： | 10 |
| 2 | Anterior vs conventional approach hepatectomy for large liver cancer:A meta-analysis显示文摘AIM:To evaluate the clinical outcomes and safety of anterior-and conventional-approach hepatectomy for patients with large liver tumors.METHODS:Pub Med,EMBASE,Google Scholar and the Cochrane Library databases were searched for randomized controlled trials(RCTs)and controlled clinical trials comparing anterior-approach hepatectomy(AAH)and conventional-approach hepatectomy(CAH).Two observers independently extracted the data using a spreadsheet and assessed the studies for inclusion.Studies that fulfilled the inclusion criteria and addressed the clinical questions of this analysis were further assessed using either fixed effects or random effects models.RESULTS:Two RCTs and six controlled clinical trials involving 807 patients met the predefined inclusion criteria.A total of 363 patients underwent AAH and 444underwent CAH.Meta-analysis indicated that the AAH group had fewer requirements for transfusion(OR=0.37,95%CI:0.21-0.63),less recurrence(OR=0.57,95%CI:0.37-0.87),and lower mortality(OR=0.29,95%CI:0.13-0.63).There were no significant differences between AAH and CAH with regard to perioperative complications(OR=0.94,95%CI:0.58-1.51),intraoperative tumor rupture(OR=0.98,95%CI:0.40-2.40),or length of hospital stay(weighted mean difference=-0.17,95%CI:-2.36-2.02).CONCLUSION:AAH has advantages of decreased transfusion,mortality and recurrence compared to CAH.It is a safe and effective method for large cancers requiring right hepatectomy. | Lei Li Hai-Qing Wang Qing Wang Jian Yang Jia-Yin Yang | 2014 | World Journal of Gastroenterology2014，20，45： | 5 |
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