| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | MiR-146a rs2910164 polymorphism increases risk of gastric cancer:A meta-analysis显示文摘AIM:To systematically evaluate the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer.METHODS:A comprehensive electronic search was conducted for articles published up until January 27,2014 in Medline(PubMed),Excerpta Medica Database(Embase),the Cochrane Library and Google Scholar.Only case-control studies published in English that evaluated the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer were included.Furthermore,only studies with sufficient data allowing for calculation of odds ratio(OR) and corresponding 95% confidence interval(CI) were included.These values were used in the quantitative synthesis to assess the strength of the association between the miR-146 a rs2910164 polymorphism and risk of gastric cancer.RESULTS:The database search identified 1002 eligible studies,of which seven(comprising 4112 cases and 5811 controls) were included for the meta-analysis.The results indicate that miR-146 a rs2910164 polymorphism is more likely to be associated with gastric cancer risk.In the overall analysis,a significantly increased cancer risk was found in the heterozygote(GG vs GC) comparison(OR = 1.14,95%CI:1.03-1.27; P = 0.01 for pooled OR).In the ethnicity subgroup analysis,a similar result was found among Caucasians(OR = 1.36,95%CI:1.01-1.85; P = 0.04 for pooled OR).In the stratified analysis by quality of studies,a significantly increased cancer risk was found in the heterozygote comparison among high quality studies(OR = 1.12,95%CI:1.01-1.26; P = 0.04 for pooled OR).When stratified on the basis of sample size,a significantly increased cancer risk was found among small sample size subgroups for the allelic(G vs C:OR = 1.16,95%CI:1.03-1.30; P = 0.01),homozygote(GG vs CC:OR = 1.33,95%CI:1.03-1.73; P = 0.03) and recessive model(GG vs GC + CC:OR = 0.05,95%CI:0.00-0.10; P = 0.03) comparisons.CONCLUSION:The miR-146 a rs2910164 polymorphism is associated with increased gastric cancer risk,particularly evident in high quality studies with small sample sized Caucasian populations. | Wen-Qun Xie Shi-Yun Tan Xiao-Fan Wang | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
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