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		题名	作者	年代	出处	被引量
	1	Calcium-dependent proteasome activation is required for axonal neurofilament degradation显示文摘Even though many studies have identified roles of proteasomes in axonal degeneration,the molecular mechanisms by which axonal injury regulates proteasome activity are still unclear.In the present study,we found evidence indicating that extracellular calcium influx is an upstream regulator of proteasome activity during axonal degeneration in injured peripheral nerves.In degenerating axons,the increase in proteasome activity and the degradation of ubiquitinated proteins were significantly suppressed by extracellular calcium chelation.In addition,electron microscopic findings revealed selective inhibition of neurofilament degradation,but not microtubule depolymerization or mitochondrial swelling,by the inhibition of calpain and proteasomes.Taken together,our findings suggest that calcium increase and subsequent proteasome activation are an essential initiator of neurofilament degradation in Wallerian degeneration.	Joo Youn Park So Young Jang Yoon Kyung Shin Duk Joon Suh Hwan Tae Park	2013	Neural Regeneration Research2013，8，36：	2

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