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| 1 | Brain-gut axis in the pathogenesis of Helicobacter pylori infection显示文摘Helicobacter pylori(H.pylori)infection is the main pathogenic factor for upper digestive tract organic diseases.In addition to direct cytotoxic and proinflammatory effects,H.pylori infection may also induce abnormalities indirectly by affecting the brain-gut axis,similar to other microorganisms present in the alimentary tract.The brain-gut axis integrates the central,peripheral,enteric and autonomic nervous systems,as well as the endocrine and immunological systems,with gastrointestinal functions and environmental stimuli,including gastric and intestinal microbiota.The bidirectional relationship between H.pylori infection and the brain-gut axis influences both the contagion process and the host’s neuroendocrine-immunological reaction to it,resulting in alterations in cognitive functions,food intake and appetite,immunological response,and modification of symptom sensitivity thresholds.Furthermore,disturbances in the upper and lower digestive tract permeability,motility and secretion can occur,mainly as a form of irritable bowel syndrome.Many of these abnormalities disappear following H.pylori eradication.H.pylori may have direct neurotoxic effects that lead to alteration of the brain-gut axis through the activation of neurogenic inflammatory processes,or by microelement deficiency secondary to functional and morphological changes in the digestive tract.In digestive tissue,H.pylori can alter signaling in the brain-gut axis by mast cells,the main brain-gut axis effector,as H.pylori infection is associated with decreased mast cell infiltration in the digestive tract.Nevertheless,unequivocal data concerning the direct and immediate effect of H.pylori infection on the brain-gut axis are still lacking.Therefore,further studies evaluating the clinical importance of these host-bacteria interactions will improve our understanding of H.pylori infection pathophysiology and suggest new therapeutic approaches. | Jacek Budzyński Maria Kopocka | 2014 | World Journal of Gastroenterology2014，20，18： | 29 |
| 2 | 幽门螺杆菌感染对中老年胃溃疡患者心理状态的影响显示文摘目的:探讨幽门螺杆菌感染对中老年胃溃疡患者心理状态的影响。方法:选取2012年6月—2016年6月于我院住院治疗的中老年胃溃疡且合并幽门螺杆菌感染共120例(观察组),选取体检健康患者共100例作为对照(对照组),使用症状自评量表(SCL-90)评价两组及观察组患者根治幽门螺杆菌感染后的心理状态评分,并进行数据比较分析。结果:观察组患者的总均分(t=5.896,P<0.001)、躯体化(t=3.260,P=0.001)、强迫症状(t=3.431,P=0.001)、人际关系敏感(t=5.911,P<0.001)、抑郁(t=6.282,P<0.001)、焦虑(t=5.366,P<0.001)、恐怖(t=5.366,P<0.001)和偏执(t=2.274,P=0.024)均显著高于对照,差异均具有统计学意义。治疗后4周,观察组患者的总均分(t=4.272,P<0.001)、躯体化(t=4.116,P<0.001)、强迫症状(t=4.482,P<0.001)、人际关系敏感(t=4.592,P<0.001)、抑郁(t=6.859,P<0.001)、焦虑(t=5.254,P<0.001)、恐怖(t=6.800,P<0.001)显著低于治疗前,差异均具有统计学意义。结论:幽门螺杆菌感染可以导致中老年胃溃疡患者产生多种负面心理,根治幽门螺杆菌感染可显著改善患者的负面心理状态。 | 王克儒 王先安 | 2017 | 中国健康心理学杂志2017，25，5： | 14 |
| 3 | Gastrointestinal motility disorders in inflammatory bowel diseases显示文摘The relationship between motility and inflammatory gastrointestinal disorders is at the same time complex and intriguing since these conditions might share some genetic,environmental,immunological and microbial predisposing factors.In addition,significant symptom overlapping may occur,muddling the waters within the clinical context.Although on one hand this represents a challenge for the clinician for a potential under-or over-treatment and diagnostic delay,on the other hand it possibly represents an opportunity for the researcher to better disclose the intimate relationship between chronic(often low-grade)inflammation,motor disorders and deranged sensory function.The best example is probably represented by Crohn’s disease and ulcerative colitis.In fact,a number of gastrointestinal motor disorders have been described in association with these diseases,disorders which span from the esophagus to the anorectum,and which will be extensively covered in this review.It is conceivable that at least part of this derangement is strictly related to inflammatory cytokine trafficking and neuromuscular changes;however,given the high prevalence of functional gastrointestinal disorders in the general population,this overlap might also be serendipitous.However,it is worth noting that literature data on this topic are relatively scarce,sometimes quite outdated,and mostly focused on the interplay between irritable bowel syndrome and inflammatory bowel disease.Nevertheless,both researchers and clinicians must be aware that symptoms related to gastrointestinal motility disorders may be highly prevalent in both active and inactive inflammatory bowel disease,correlate with greater psychological comorbidity and poorer quality of life,and may negatively influence the therapeutic approaches. | Gabrio Bassotti Elisabetta Antonelli Vincenzo Villanacci Marianna Salemme Manuela Coppola Vito Annese | 2014 | World Journal of Gastroenterology2014，20，1： | 11 |
| 4 | 慢性胃炎患者幽门螺杆菌认知度及影响因素调查分析显示文摘目的调查慢性胃炎患者对H.pylori感染的认知情况及其影响因素。方法采用随机抽样法抽取2021年8月至12月至西京医院就诊的378例慢性胃炎患者作为研究对象,其中慢性萎缩性胃炎(CAG)组84例,CAG伴肠化生(IM)组294例。应用自制调查问卷对患者疾病认知情况进行调查,采用数字评分法对患者的心理健康、生活质量和疾病关联程度进行调查分析。结果在是否了解H.pylori、碳尿素呼气试验检测方法、慢性萎缩性胃炎相关疾病、传播途径、共餐聚会、不分餐和坚持就诊等方面CAG伴IM组的认知率明显高于慢性非萎缩性胃炎(CNAG)组,均存在显著性差异(P均<0.05)。而在慢性胃炎相关疾病和饮食不洁方面CNAG组认知率明显高于CAG伴IM组,均存在显著性差异(P均<0.05)。此外,认知情况还受年龄、居住地、文化程度、饮食方式、H.pylori感染状态和外卖食用次数等因素的影响。两组患者在健康知识获取途径、心理健康影响、发病关联程度和生活质量方面均无显著性差异(P>0.05)。而胃黏膜病变程度对患者疾病关联程度方面的影响存在显著性差异(P<0.05)。结论我们应根据影响慢性胃炎患者H.pylori认知水平的潜在因素对H.pylori感染患者进行心理干预和健康指导。此外,还要加大对健康人群H.pylori的科普工作,提倡医患并举,全民参与,共同预防的理念。 | 刘洁 杨华 穆清华 赵梓彤 李佳 张楠 | 2022 | 现代消化及介入诊疗2022，27，7： | 8 |
| 5 | 幽门螺杆菌感染对心理状态的影响显示文摘目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染对患者心理状态的影响.方法:连续选择2014-10/2015-05铜陵市市立医院消化内科住院的^(13)C尿素呼气试验(^(13)C-urea breath test,^(13)C-UBT)阳性的84例H.pylori感染患者作为研究组,随机选择同期门诊体检中^(13)C-UBT阴性的84例健康人群作为对照组,分别采用90项症状清单(symptom check list 90,SCL-90)进行评分并比较两组的差异.84例H.pylori感染患者入院后均给予H.pylori根除治疗,4wk后复查^(13)C-UBT,对根治成功、^(13)C-UBT阴性者再次采用SCL-90量表进行评分,比较治疗前后的差异.结果:H.pylori感染者与健康人群以及H.pylori根除治疗前后相比较,在躯体化、强迫症状、人际关系敏感、抑郁、焦虑、恐惧方面具显著差异,具有统计学意义(P<0.05).对根治成功者治疗前后的SCL-90评分进行比较,结果发现患者的躯体化、强迫症状、人际关系敏感、抑郁、焦虑及恐惧症状得到明显缓解.结论:H.pylori感染可使患者产生明显的负性心理,成功根除H.pylori可明显改善患者的心理状态. | 胡斌 孔德润 王笑 | 2015 | 世界华人消化杂志2015，23，36： | 6 |
| 6 | 增龄对大鼠肠黏膜上皮屏障功能的影响显示文摘目的了解大鼠肠道上皮屏障功能随增龄所发生的变化。方法选用3月龄组、12月龄组、24月龄衰老模型鼠组,每组各10只。取大鼠末端回肠制作切片观察小肠黏膜形态学变化及绒毛高度、厚度等。采用免疫组化Envision两步法、反转录-聚合酶链反应(RT—PCR)方法检测大鼠末端回肠黏膜的紧密连接蛋白闭锁蛋白(Occludin)、闭锁小带蛋白(ZO-1)的分布和表达。结果24月龄衰老模型鼠、12月龄大鼠小肠黏膜厚度及绒毛高度均较3月龄降低[小肠黏膜厚度:24月龄(87.6±6.32)μm,12月龄(131.8±5.22)μm,3月龄(162.9±7.28)μm,P〈0.05;绒毛高度:24月龄(56.4±5.38)μm,12月龄(76.7±5.40)μm,3月龄(108.1±6.42)μm,P〈0.053,且24月龄衰老模型鼠小肠黏膜厚度及绒毛高度较12月龄亦降低(P〈0.05)。24月龄衰老模型鼠、12月龄大鼠小肠黏膜组织中紧密连接蛋白(Occludin、ZO-1)表达均较3月龄减少(Occludin蛋白:24月龄(2.23±0.60)%,12月龄(4.21±0.61)%,3月龄(12.31±0.94)%,P〈0.05;ZO-1蛋白:24月龄(2.03±0.54)%,12月龄(4.02±0.65)%,3月龄(12.21±0.81)%,P〈0.053,24月龄衰老模型鼠小肠黏膜组织中紧密连接蛋白(Occludin、ZO-1)表达较12月龄亦降低(P〈0.05)。24月龄衰老模型鼠和12月龄大鼠小肠黏膜组织中OccludinmRNA和ZO-lmRNA相对表达量较3月龄减少(OccludinmRNA:24月龄0.20±0.03,12月龄0.38±0.02,3月龄0.66±0.03,P〈0.05;ZO-1mRNA:24月龄0.18±0.03,12月龄0.37±0.02,3月龄0,63土0.03,P〈0.05),24月龄衰老模型组与12月龄组比较差异有统计学意义(P〈0.05)。结论随着年龄的增长大鼠小肠黏膜厚度及绒毛高度逐渐降低,小肠黏膜的紧密连接蛋白逐渐减少,小肠黏膜屏障功能受损。 | 吴克芬 李希 任卫英 胡予 | 2013 | 中华老年医学杂志2013，32，9： | 5 |
| 7 | 衰老对小鼠肠黏膜上皮屏障功能影响的实验研究显示文摘目的:研究衰老对小鼠肠黏膜上皮屏障结构与功能的影响。方法:雄性SPF级C57BL/6小鼠按发育阶段的不同分为1月龄组、6月龄组、10月龄组、12月龄组。采用HE染色、PAS(高碘酸-Schiff试剂)染色、甲苯胺蓝染色对小肠黏膜形态与结构进行观察测量并统计免疫细胞数量;免疫组织化学染色检测紧密连接蛋白(Occludin)的表达。结果:随着月龄增加,小鼠小肠各段绒毛长度均呈降低趋势,相同月龄不同肠段相比,绒毛长度从十二指肠到空肠、回肠呈递减趋势。十二指肠绒毛宽度呈先增高后降低趋势,空肠和回肠绒毛宽度呈下降趋势。十二指肠隐窝深度随月龄增高呈增高趋势,空肠和回肠的隐窝深度随月龄增长呈先增高后降低趋势。随月龄增长,小鼠十二指肠、空肠、回肠各肠段中上皮内淋巴细胞数和肠壁固有层肥大细胞呈先增高后降低趋势,杯状细胞数呈下降趋势。小肠上皮黏膜组Occludin表达随着月龄升高逐渐减少。结论:衰老过程中,小鼠小肠形态发生了一系列结构性改变,黏膜组织中免疫细胞数量减少,肠黏膜上皮屏障免疫相关功能下降。 | 王汉琨 张丁 宋莉 于莉 宋银宏 王德成 | 2018 | 中国免疫学杂志2018，34，10： | 3 |
| 8 | 有消化道症状者幽门螺杆菌感染与焦虑抑郁状态的相关性显示文摘【目的】讨论有消化道症状者幽门螺杆菌(Helicobacter pylori,Hp)感染与焦虑、抑郁状态的相关性,并分析其影响因素。【方法】256例有消化道症状者均进行Hp检查(13C或14C呼气试验)并使用焦虑自评量表(self-rating anxiety scale,SAS)和抑郁自评量表(self-rating depression scale,SDS)评估患者的焦虑、抑郁状态。【结果】256例患者,其中Hp感染者146例,感染率为57%。Hp感染者的焦虑和抑郁得分均高于无HP感染者(P<0.05),且患者焦虑、抑郁程度越重,幽门螺杆菌感染率越高。(χ^(2)=17.241,P=0.001;χ^(2)=17.245,P=0.000)。经二元Logistic回归分析可知,饮酒(OR=2.281,95%CI:1.166~4.466,P=0.016)、女性(OR=2.013,95%CI:1.124~3.604,P=0.019)、抑郁状态(OR=2.006,95%CI:1.219~3.301,P=0.006)、焦虑状态(OR=1.713,95%CI:1.098~2.672,P=0.018)、BMI增加(OR=1.112,95%CI:1.016~1.218,P=0.022)是Hp感染的影响因素(P<0.05)。【结论】有消化道症状者Hp感染与多种因素相关,与焦虑、抑郁状态相互影响,具有相关性。 | 鲁钰 方向明 | 2021 | 武警后勤学院学报(医学版)2021，30，4： | 3 |
| 9 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
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