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| 1 | The value of postoperative hepatic regional chemotherapy in prevention of recurrence after radical resection of primary liver cancer显示文摘INTRODUCTIONIn China,primary liver cancer (PLC) ranks secondin cancer mortality since the 1990s.In the field ofPLC treatment,surgical resection remains the best,which includes large PLC resection,small PLCresection,re-resection of subclinical recurrence,aswell as cytoreduction and sequential resection forunresectable PLC.However,recurrence | Wu ZQ Fan J Qiu SJ Zhou J Tang ZY | 2000 | World Journal of Gastroenterology2000，6，1： | 19 |
| 2 | Comparison of methods for total community DNA extraction and purification from compost显示文摘 | Yang ZH Xiao Y Zeng GM Xu ZY Liu YS | 2007 | 中国生物学文摘2007，21，8： | 18 |
| 3 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 4 | Effects of combined splenorenal shunt devascularization and devascularization only on hemodynamics of the portal venous system in patients with portal hypertension显示文摘Shunt and devascularization have totally different effects on hemodynamics of the portal venous system , and the actual results of combined shunt and devascularization should be determined by more clinical observations. This study aimed to evaluate effects on hemodynamics of the portal venous system after conventional spleno-renal shunt combined with pericardial devascularization and pericardial devascularization only. METHODS: In 20 patients who had received conventional splenorenal shunt combined with pericardial devascularization(CP) and 18 who had received pericardial devascularization and splenectomy (PCDV), hemodynamic parameters of the portal venous system were studied by magnetic resonance angiography 1 week before and 2 weeks after operation. Free portal pressure was detected continuously by a transducer during the operation. RESULTS: Compared to the preoperative data, a decreased flow of the portal vein (PVF) (563.12±206.42 ml/min vs 1080.63±352.85 ml/min, P<0.05), a decreased diameter of the portal vein (PVD) (1.20±0.11 cm vs 1.30±0.16 cm, P<0.01 ), a decreased free portal preasure ( FPP ) (21.50±2.67 mmHg vs 29.88±2.30 mmHg, P<0.01) and an increased flow of the superior mesenteric vein (SMVF) (1105.45±309.03 ml/min vs 569.13±178.46 ml/min, P < 0.05) were found in the CP group after operation; a decreased PVD (1.27±0.16 cm vs 1.40±0.23 cm, P<0.05), a decreased PVF (684.60±165.73 ml/min vs 1175.64±415.09 ml/min, P<0.05), a decreased FPP (24.40±3.78 mmHg vs 28.80±3.56 mmHg, P<0.05) and an increased SMVF (697.91+121.83 ml/min vs 521.30±115.82 ml/min, P<0.05) were found in the PCDV group. After operation, the PVF of CP group (563.12±206.42 ml/min vs 684.60±165.73 ml/min, P>0.05) was not decreased significantly while FPP (21.50±2.67 mmHg vs 24.40±3.78 mmHg, P< 0.01) was decreased significantly as compared with that of the PCDV group. PVF and FPP could be decreased by both surgical procedures, but the effect of decreasing FPP is much better in the combined procedures than in PCDV. Since there is no significant difference in PVF between the two groups, the combined procedures could integrate advantages of shunt with those of the devascularization, maintaining the normal anatomy structure of the hepatic portal vein, and should be one of the best choices for patients with PHT when surgical interventions are considered. | Department of General Surgery, Renji Hospital, Shanghai 200127, China (Cao H, Hua R and Wu ZY) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 18 |
| 5 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 6 | Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis显示文摘 | Zheng, ZY Lee, AW Zhan, XB Shi, Z Wang, L Zhu, L Wu, JR Lin, CC | 2007 | 中国生物学文摘2007，21，10： | 13 |
| 7 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 8 | Association of nonalcoholic fatty liver disease with type 2 diabetes: clinical features and independent risk factors in diabetic fatty liver patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common chronic liver disease in China, of which diabetic fatty liver (DFL) accounts for a large proportion in clinic. DFL is a disease without specific clinical features and lacking of confirmatory laboratory tests, and the etiology of hepatic steatosis remains poorly understood. The aim of this paper was to explore the clinical characteristics and to determine associated risk factors in type 2 diabetes patients with fatty liver. METHODS: A total of 166 patients, 53 in DFL group and 113 in NDFL(diabetes without fatty liver) group participated in this study. Serum fasting blood glucose (FBG), alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphate (AKP), gamma glutamyl transpeptidase (GGT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured in both groups. And these variables were analyzed by using Student’ s t test and logistic regression model. RESULTS:A progressive increase in the level of FBG, ALT, AST, AKP, GGT, TG( P<0.05) and a decrease of HDL-C(P<0.01)were observed from DFL group to NDFL group. And there was no statistical difference in the level of TC between the two groups. CONCLUSIONS:Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. The successive escalation of serum ALT and TG levels and the lower HDL-C level are the independent risk factors of DFL. | Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Jin HB, Gu ZY, Yu CH and Li YM) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 9 | Hepatology International|HBV相关慢加急性肝衰竭合并细菌感染患者预后模型的建立和验证显示文摘细菌感染是HBV相关慢加急性肝衰竭(HBV-ACLF)最常见的并发症之一,可导致高病死率。然而,目前关于HBV-ACLF合并细菌感染患者的预后模型建立的研究未见报道。该研究旨在建立和验证一个能预测HBV-ACLF合并细菌感染患者30 d死亡风险的临床模型。研究者筛选2018年6月—2020年12月在华中科技大学同济医学院附属同济医院被诊断为HBV-ACLF的住院患者,共513例患者纳入前瞻性队列,其中224例合并细菌感染患者纳入建模队列。通过logistic回归分析筛选出独立预测因素并建立预测HBV-ACLF合并细菌感染患者30 d死亡风险列线图。同时回顾性筛选2016年1月—2018年5月在该院被诊断为HBV-ACLF的住院患者,共192例患者纳入验证队列,用于评估列线图的区分度、校准度和临床实用性。 | 张忠威 陈韬 宁琴 YANG ZY CHENG QY | 2022 | 临床肝胆病杂志2022，38，4： | 9 |
| 10 | 磁共振单次扫描多组织对比序列对颈动脉粥样硬化斑块评价的临床初步研究显示文摘目的评价MR 3D单次扫描多组织对比序列(MATCH)定量评价颈动脉血管形态学和定性评价斑块内成分的价值。方法选择超声检查发现颈动脉狭窄>50%且拟行颈动脉内膜剥脱术患者30例,术前分别行MATCH(5min)及MRI常规多序列扫描(T1WI,T2WI,三维时间飞跃和质子密度加权像,18min),扫描范围以颈动脉分叉为中心覆盖全部斑块。用MRI-Plaque View软件分析斑块形态学参数:管腔面积(LA)、管壁面积(WA)、标准化管壁指数(NWI),定性评价斑块内成分,包括斑块内出血(IPH)、斑块钙化(CA)、斑块脂质核心(LRNC)。用Cohen kappa分析2种序列对斑块内成分定性的一致性。结果 30例患者双侧颈动脉入选898个图像层面,MATCH和常规序列LA[(36.27±24.23)mm2 vs(35.72±20.12)mm2,t=1.87,P=0.062],WA[(42.80±20.67)mm2 vs(43.64±24.87)mm2,t=1.74,P=0.082],NWI[(59.21±13.90)vs(59.81±13.96),t=1.80,P=0.072]无显著差异。MATCH与常规序列判断斑块内成分有中到高度的一致性(LRNC:κ值=0.840,CA:κ值=0.802,IPH:κ值=0.773)。结论 MATCH有可能成为评估颈动脉易损斑块成分及斑块破裂危险程度的新方法。 | 杨利新 于薇 Fan ZY Xie YB 王占宏 Bi XM 安靖 张天静 Li DB | 2015 | 中华老年心脑血管病杂志2015，17，11： | 8 |
| 11 | Intrahepatic transplantation of hepatic oval cells for fulminant hepatic failure in rats显示文摘AIM:To evaluate the effect of intrahepatic transplantation of hepatic oval cells(HOC)on fulminant hepatic failure(FHF)in rats.METHODS:HOC obtained from rats were labeled with green fluocescent protein(GFP)or 5,6carboxyfluorescein diacetate succinmidyl ester(CFDASE).Cell fluorescence was observed under fluorescent microscope at 6,24,48 and 72 h after labeling.CFDASE labeled HOC(5×10 6 cells each rat)were injected into livers of rats with FHF induced by D-galactosamine.Serum albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)levels were measured at different time points.Liver function of rats was examined on days 3,7,14 and 21 after HOC transplantation.RESULTS:The positive rate of GFP and CFDA-SE labeled HOC was 10%and 90%,respectively,with no significant change in cell viabilities.The survival rate was higher in HOC transplantation group than in control group,especially 48(9/15 vs 6/15)and 72 h(9/15 vs 4/15)after HOC transplantation.The serum ALT,AST and TBil levels were decreased while the serum Alb level was increased after HOC transplantation.Fluorescence became faded and diffused in liver tissues,suggesting that proliferation and differentiation occur in transplanted HOC.CONCLUSION:CFDA-SE is superior to GFP in labeling HOC,although fluorescence intensity is decreased progressively with cell division.HOC transplantation can improve the liver function and increase the survival rate of recipients. | Chen-Xuan Wu,Qi Zou,Zheng-Yan Zhu,Ying-Tang Gao,Yi-Jun Wang,Department of Hepatobiliary,The Third Center of Affiliated Hospital of Tianjin Medical University Key Laboratory of Artificial Cells of Tianjin,Tianjin 300170,China Author contributions:Wang YJ,Wu CH and Zou Q designed the research Zou Q,Zhu ZY,Gao YT performed the research Zou Q analyzed the data Wang YJ and Wu CX wrote the paper.Supported by Tianjin Science Committee,Grant No.05SYSYJC02600 and Tianjin Health Bureau,Grant No.05KYR01 | 2009 | World Journal of Gastroenterology2009，15，12： | 7 |
| 12 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 13 | TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve显示文摘TRHmicroinjectionintoDVCenhancesmotilityofrabbitsgalbladderviavagusnerveLIUChuanYong,LIUJingZhang,ZHOUJianHua,WANGHanRu,... | Liu, CY Liu, JZ Zhou, JH Wang, HR Li, ZY Li, AJ Liu, KJ | 1998 | World Journal of Gastroenterology1998，4，2： | 4 |
| 14 | Radiotherapy of double primary esophageal carcinoma显示文摘INTRODUCTIONDouble primary esophageal carcinoma is defined ashaving two loci of squamous cell cancersimultaneously or consecutively developing indifferent sites of esophagus.This rare diseaseappears mostly in the literature as case reports,reports about its treatment are even moreinfrequent.Here we present our experiences | Xiao ZF Yang ZY Zhou ZM Yin WB Gu XZ | 2000 | World Journal of Gastroenterology2000，6，1： | 4 |
| 15 | Bacterial communities inside and in the vicinity of the Chinese Great Wall Station, King George Island, Antarctica显示文摘 | Xiao X Li MG You ZY Wang FP | 2007 | 中国生物学文摘2007，21，8： | 3 |
| 16 | cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesolides显示文摘 | Cao YY Cao YB Xu Z Ying K IA Y Xie Y Zhu ZY Chen WS Jiang YY | 2006 | 第二军医大学学报2006，27，4： | 3 |
| 17 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 18 | AN SQP ALGORITHM WITH NONMONOTONE LINE SEARCHFOR GENERAL NONLINEAR CONSTRAINED OPTIMIZATION PROBLEM显示文摘In this paper, an SQP type algorithm with a new nonmonotone line search technique for general constrained optimization problems is presented. The new algorithm does not have to solve the second order correction subproblems for each iterations, but still can circumvent the so-called Maratos effect. The algorithm’s global convergence and superlinear convergent rate have been proved. In addition,we can prove that, after a few iterations, correction subproblems need not be solved,so computation amount of the algorithm will be decreased much more. Numericalexperiments show that the new algorithm is effective. | He, GP Diao, BQ Gao, ZY | 1997 | Journal of Computational Mathematics1997，15，2： | 3 |
| 19 | In vitro expansion of a multipotent population of human neural progenitor cells显示文摘 | Carpenter MK Cui X Hu ZY | | 0，，： | 3 |
| 20 | THE MULTI-PARAMETERS OVERRELAXATION METHOD显示文摘In this paper, first, we present the comparison theorem and the (generalized) Stein-Rosenberg theorem for the GMPOR method, which improves some recent results[9,11,13]. Second, we also give the convergent theorem of the GMPOR method, which generalizes the corresponding result of [9]. Finally, we provide the real interval such that the generalized extrapolated Jacobi iterative method and the generalized SOR methods simultaneously converge, one of the main results in [1] is extended. | Li, W You, ZY | 1998 | Journal of Computational Mathematics1998，16，4： | 3 |
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