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| 1 | Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis. | Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu | 2019 | Bone Research2019，7，2： | 5 |
| 2 | Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery显示文摘为指向的同时的肿瘤的 Subcellular 细胞器特定的 nanoparticles,成像,和药交货具有对癌症治疗的庞大的兴趣。此处,我们报导一根选择指向线粒体的探针 1,它被与 cyanostilbene 和长烷基链一半合并 triphenyl 磷化氢综合。探查 1 被发现经由导致聚集的排放(AIE ) 显示荧光。低分子重量的基于 cyanostilbene 的探查有或没有 anticancer 药, 1 与 ca 形成了狭窄的同类的 nanorod。有 ca 的长度或 nanoparticles 的 110 nm。在水的媒介的 20 nm 直径。自我装配的 cyanostilbene nanoparticles (N1 ) 有选择地在癌症房间的线粒体积累了并且射出荧光。N1 也能交付 anticancer 药, doxorubicin (纪录影片) ,到有高效率的线粒体。更重要地, N1 在正常房间上为癌症房间展出了高度选择的 cytotoxicity。到生物系统的这自我装配的 nanoparticle 的大潜在的应用程序源于它在线粒体聚集的能力。这聚集在癌症房间在 mitochondrial 膜潜力在细胞内部的反应的氧种类并且到减少的产生导致了重要增加。而且,在老鼠的肿瘤织物举起实验建议自我装配的 N1 有能力使内在化并且有效地交付 anticancer 药进肿瘤纸巾。而且, N1 和包含 N1 的 doxorubicin (N1 纪录影片) 有效地在 vivo 在一个异种皮移植模型压制了肿瘤生长。一起拿,我们的调查结果显示 N1 的应用程序为潜在的指导图象的治疗以及一个地点特定的交货系统作为指向探查,药交货平台,和化学疗法的代理人的 mitochondrial 提供唯一的策略给癌症房间。 | Ka Young Kim Hanyong Jin Jaehyeon Park Sung Ho Jung Ji Ha Lee Hyesong Park Sung Kuk Kim Jeehyeon Bae Jong Hwa Jung | 2018 | Nano Research2018，11，2： | 4 |
| 3 | 微波辐射辅助柠檬酸络合法制备的Ho^(3+)/Tm^(3+)/Yb^(3+)共掺杂CaWO_4的白光性能(英文)显示文摘采用微波辐射辅助柠檬酸络合法制备Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶升频转换荧光粉。将柠檬酸络合物前驱体在300~700°C热处理3 h。Ho3+/Tm3+/Yb3+共掺杂CaWO4C在400°C时开始结晶,在600°C时结晶完成。经600°C热处理的Ho3+/Tm3+/Yb3+共掺杂CaWO4主要呈球形,且形态均匀。在980 nm的激光激发下,Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶出现肉眼可见的明亮的白色升频转换发射,这种现象来自Tm3+的475 nm蓝光发射以及Ho3+的543 nm绿光和651 nm红光发射。通过调整Tm3+和Ho3+的浓度可以控制Ho3+/Tm3+/Yb3+共掺杂CaWO4的CIE色度图从冷到暖白色之间变化。讨论了Tm3+和Ho3+浓度对升频转换光性能的影响以及与激光泵功率相关的影响机制。 | Hyun CHO Seok Min HWANG Jae Bin LEE Dong Hyun KA Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 4 | Behavior in mice with targeted disruption of single genes 显示文摘 | Nelson RJ young KA | 1998 | Neurosci Biobehav Rev1998，22，3： | 1 |
| 5 | Isolation and genet- ic mapping of a non-lethal rice low phytic acid 1 mutation 显示文摘 | Larson SR Rutger JN Young KA | 2000 | Crop Science2000，40，： | 1 |
| 6 | Controlled ovulation of the dominant follicle : a critical role for LH in the late follicular phase of the menstrual cycle 显示文摘 | Young KA Chaffin CL Molskness TA | 2003 | Hum Reprod2003，18，： | 1 |
| 7 | Predictors of intention to exercise to reduce stroke risk among people at risk of stroke : An application of an extended Health Belief Model 显示文摘 | Sullivan KA White K Young R | 2008 | Rehabilitation Psychology2008，53，4： | 1 |
| 8 | Isolation of high seed inorganic P, low phytate soybean mutants 显示文摘 | Wilcox JR Premachandra GS Young KA | 2000 | Crop Science2000，40，： | 1 |
| 9 | Short photoperiods reduce vascular endothelial growth factor in the testes of Peromyscus leucopus 显示文摘 | Young KA Nelson RJ | 2000 | Am J Physiol Regul Integr Comp Physiol2000，79，3： | 1 |
| 10 | Elevated neuron number in the limbic thalamus in major depression 显示文摘 | Young KA Holcomb LA Yazdanl U | 2004 | Am J Psychiatry2004，161，7： | 1 |
| 11 | Hepatic enhancement in colorectal cancer texture analysis correlates with hepatic hemodynamics and patient survival显示文摘 | Ganeshan B Miles KA Young RC | 2007 | Acad Radiol2007，14，12： | 1 |
| 12 | Texture analysis in non-contrast enhanced CT:impact of malignancy on texture in apparently disease-free areas ofthe liver显示文摘 | Ganeshan B Miles KA Young RC | 2015 | Eur J Radiol2015，70，1： | 1 |
| 13 | Dynamic expression of mRNAs and proteins for matrix metalloproteinases and their tissue inhibitors in the primate corpus luteum during the menstrual cycle显示文摘 | Young KA Hennebold JD Stouffer RL | 2002 | Mol Hum Reprod2002，8，9： | 1 |
| 14 | The Cerebrovascular Attitudes and Beliefs Scale ( CABS- R ) : the factor structure and psychometric properties of a tool for assessing stroke-related health beliefs 显示文摘 | Sullivan KA White KM Young RM | 2010 | Int J Behav Med2010，17，1： | 1 |
| 15 | Role of caspase-3 in ethanol-induced developmental neurodegeneration显示文摘 | Young C Roth KA Klocke B J | 2005 | Neurobiol Dis2005，20，2： | 1 |
| 16 | Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample显示文摘 | Skol AD Young KA Tsuang DW | 2003 | Am J Med Genet B Neuropsychiatr Genet2003，118，： | 1 |
| 17 | Lymphangioleiomyomatosis:new concepts in pathogenesis,diagnosis,and treatment显示文摘 | Meraj R Wikenheiser-Brokamp KA Young LR | 2012 | Semin Respir Crit Care Med2012，33，5： | 1 |
| 18 | Vitamin D deft- eiency and coronary artery calcification in subjects with type 1 dia- betes显示文摘 | Young KA Snell-Bergeon JK Naik RG | 2011 | Diabetes Care2011，34，2： | 1 |
| 19 | Post - weaning social isolation alters anxiety - related behavior and neurochemicai gene expression in the brain of male prairie voles显示文摘 | Pan Y Liu Y Young KA | 2009 | Neurosci Lett2009，454，1： | 1 |
| 20 | Modest evidence for linkage and possible confirmation of association between NOTHC4 and schizophrenia in a large Veterans Affairs Cooperative Study sample显示文摘 | Skol AD Young KA Tsuang DW | 2003 | Am J Med Genet2003，18，1： | 1 |
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