|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 丙型肝炎病毒准种多样性与病毒血症水平、疾病活动度及干扰素疗效的关系显示文摘目的 了解丙型肝炎病毒 (HCV)准种变异与病毒血症水平、疾病活动度及干扰素疗效的关系。方法 采用针对HCVE2高变区 1 (HVR1 )的单链构象多态性分析法 (SSCP)对 68例慢性丙型肝炎患者进行HCV准种检测 ,分析准种数目与HCVRNA、ALT、AST水平及肝组织活动指数 (HAI)的相关性。对其中 48例给予干扰素治疗 ,分析准种数目对干扰素应答效果的影响。结果 61例HVR1SSCP阳性 ,HCV准种数目为 (6 2± 2 4)条。准种数量与HCVRNA水平显著相关 (P <0 0 1 ) ,与ALT、AST及HAI无明显相关 (P >0 0 5)。干扰素治疗患者中 ,43例HVR1阳性 ,持续应答者治疗前HCV准种数量 (3 3± 1 2 ,n =1 1 )显著少于获得治疗终点应答 (ETR)伴复发者 (6 3± 2 2 ,n =1 2 ,P <0 0 5)或无应答者 (8 0± 3 3 ,n=2 0 ,P <0 0 1 )。治疗结束时 ,干扰素组仍有 1 6例检测出HCV准种 ,但准种条数降为 (3 4± 1 2 )条 ,与未接受干扰素治疗病例的准种数目 (6 8± 2 5)相比差异有显著性 ,P <0 0 1 ) ,且其中 1 0例准种模式发生了改变。结论 HCV准种多样性可引起较高的病毒血症水平 ,但与疾病活动度无关 ;准种数目可作为预测慢性丙型肝炎干扰素疗效的指标。 | 唐小平 袁小珍 钱可平 Jhonson YN Lau | 2002 | 中华实验和临床病毒学杂志2002，16，2： | 6 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 4 | Structure of nano-copper and nano-conductive fibers显示文摘VARIOUS small inorganic solid grain catalysts, alloys and films consisting of various nano-size particles were prepared by chemical methods. The study of catalytic properties of nanostructured materials integrated material physics with chemistry, which promoted the development of materials science. | Zhang, ZK Cui, ZL Chen, KZ Wang, YN Ning, YP | 1997 | Chinese Science Bulletin1997，42，18： | 4 |
| 5 | 脉冲电镀Fe-Sb合金显示文摘在含硫酸亚铁铵、氧化锑、柠檬酸和柠檬酸钾的镀液中,用脉冲电镀方法可获光亮细致、结合力良好的Fe-Sb合金。讨论了导通时间、关断时间、峰值电流密度、脉冲频率、占空比以及搅拌对合金镀层成分的影响,提出了极限导通时间和极限关断时间两个脉冲参数的概念,据此可有效地选择脉冲参数并控制合金镀层的成分。 | 杜楠 Sada.,YN | 1995 | 电镀与环保1995，15，2： | 3 |
| 6 | 聚合物的粘弹性力学基础分子理论、实验和模拟,第2版显示文摘本书的第1版在2003年出版,现在是第2版,增加了第14—18章。本书详细介绍了聚合物粘弹性中的Rouse分子理论和扩展的蠕变理论,用定量分析方法解释了试验结果,蒙特卡洛模拟成功地显示粘弹性响应的熵的范围,模拟研究给出在粘弹性响应中能量驱动模式和熵驱动模式共存的自然解释, | Lin Yn—Hwang | 2011 | 国外科技新书评介2011，，2： | 2 |
| 7 | Role of apoptosis in the cytotoxic effect mediated by daunorubicin in cultured human retinal pigment epithelial cells 显示文摘 | Wang YS Hui YN Wiedemann P | 2002 | J Ocul Pharm Ther2002，18，4： | 2 |
| 8 | 老年局灶性前列腺癌患者选行治疗与观察对其远期存活率影响间差异显示文摘 | Wong YN 袁志敏(摘) | 2007 | 国外医学(老年医学分册)2007，28，5： | 2 |
| 9 | Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers显示文摘 | Wong YN King SP Laughton WB | 1998 | J Clin Pharmacol1998，38，3： | 2 |
| 10 | Open-label,single-dose pharmacokinetic study of modafinil tablets:influence of age and gender in normal subjects显示文摘 | Wong YN King SP Simcoe D | 1999 | J Clin Pharmacol1999，39，3： | 2 |
| 11 | Effect of polysaccharides from Angelica sinensis on gastric ulcer healing显示文摘 | Ye YN So HL | 2003 | Life Sciences2003，72，8： | 2 |
| 12 | Polarographic Catalytic Wave of Lysozyme显示文摘This paper reports a polarographic catalytic wave of lysozyme (LE) in the presence ofKIO3. The mechanism of the catalytic wave was discussed. It is illustrated by the catalytic wave ofLE that, besides the Brdicka current, there exists a new kind of catalytic wave of protein. | Gou, W Yang, YN Song, JF | 1998 | Chinese Chemical Letters1998，9，6： | 2 |
| 13 | Recovery of (t)-lactic acid by anion exchange resin amberlite IRA-400显示文摘 | CAO X YN H S KOO Y | 2002 | Biochem Engg Joum2002，11，23： | 1 |
| 14 | NF-IL6 a member of the C/EBP family of transcription factors binds and trans-activates the human MDRI gene promoter显示文摘 | Combates N J Rzepka RW Chen YN | 1994 | Biol Chem1994，269，29： | 1 |
| 15 | Embryonal sarcoma of the liver:multiple recurrences and histologic dedifferentiation显示文摘 | Cho HS Park YN Lyu CJ | 1999 | Med Pediatr Oncol1999，32，： | 1 |
| 16 | Some recent results in the theory of the Wiener number 显示文摘 | Gutman I Yeh YN Lee SL Chen JC | 1993 | Indian J Chem1993，32，： | 1 |
| 17 | An in vivo study of the host tissue response to subcutaneous implantation of PLGA-and/or porcine small intestinal submucosa-based scaffolds显示文摘 | Kim MS Ahn HH Shin YN | 2007 | Biomaterials2007，28，34： | 1 |
| 18 | Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2 显示文摘 | Li M Chen Q Shen YN | 2009 | Exp Dermatol2009，18，7： | 1 |
| 19 | Intracanial stenosis in Chinese patients with acute stroke显示文摘 | Wong GS Huang YN Gao S | 1998 | Neurology1998，50，3： | 1 |
| 20 | Variations on the Notch pathway in neu- ral development显示文摘 | Justice N J Jan YN | 2002 | Curr Opin Neurobiol2002，12，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员