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| 1 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | A rapid quantitative measurement of root length and root branching by microcompater image analysis显示文摘 | Zoon F C Van Tienderen PH | 1990 | Plant and Soil1990，126，： | 2 |
| 3 | Is the reliability of a visual analog scale higher than an ordinal scale? An experiment with the GRBAS scale for the perceptual evaluation of dysphonia显示文摘 | Wuyts FL De Bodt MS Van de heyning PH | 1999 | J Voice1999，13，： | 1 |
| 4 | Red wine and red wine polyphenolic compounds but not alcohol inhibit ADP-induced platelet aggregation显示文摘 | De Lange DW van Golden PH Scholman WL | 2003 | Eur J Intern Med2003，14，6： | 1 |
| 5 | Decreased retinal ganglion cell layer thickness in patients with type 1 diabetes 显示文摘 | van Dijk HW Verbraak FD Kok PH Garvin M Sonka M Lee K | 2010 | Invest Ophthalmol Vis Sci2010，51，7： | 1 |
| 6 | 显示文摘 | Shimizu H Van Golde PH | 1992 | Biochem J1992，286，： | 1 |
| 7 | Effects of transient intracranial hypertension on lung fiuid and protein exchange显示文摘 | van der Zee H Neumann PH Minnear FL | 1983 | Apph Physiol1983，54，1： | 1 |
| 8 | Three novel mutations in five unrelated subiects with heredi- tary protein S deficiency type I 显示文摘 | Reitsma PH Ploos van Amstel HK Bertina RM | 1994 | J Clin Invest1994，93，2： | 1 |
| 9 | Filter run time in CVVH:pre-versus post-dilution and nadroparin versus regional heparin-protamine anticoagulation显示文摘 | van der Voort PH Gerritsen RT Kuiper MA | 2005 | Blood Purif2005，23，3： | 1 |
| 10 | Advances in the three-portal technique for anatomical single-or double-bundle ACL recon-struction 显示文摘 | Araujo PH van Eck CF Macalena JA | 2011 | Knee Surg Sports Tranmatol Arthrosc2011，19，8： | 1 |
| 11 | Early neurodegeneration in the retina of type 2 diabetic patients显示文摘 | Van Dijk HW Verbraak FD Kok PH | | 0，，： | 1 |
| 12 | Radiotherapy for T1- 2N0 glottic cancer:a multivariate analysis of predictive factors for the long-term outcome in 1050 patients and a prospective assessment of quality of life and voice handicap index in a subset of 233 patients显示文摘 | A1-Mamgani A van Rooij PH Woutersen DP | 2013 | Clin Oto- laryngol2013，38，4： | 1 |
| 13 | The spectrum of antecedent infections in Guillain-Barre syndrome: a case control stydy显示文摘 | Jacobs BC Rothbarth PH van der Meche FG | 1998 | Neurology1998，51，4： | 1 |
| 14 | Interleukin 8 and venous thrombosis:evidence for a role of inflammation in thrombosis显示文摘 | REITSMA PH ROSENDAAL FR | 2002 | Br J Haematol2002，116，5： | 1 |
| 15 | Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitis显示文摘 | Rather PH Wingertzahn MA van Bavel JH | 2006 | J Allergy Clin Immunol2006，118，5： | 1 |
| 16 | Preoperative selection of patients with low stage endometrial cancer at high risk for pelvic lymph node metastases显示文摘 | Van Doorn HC Van der Zee AG Peeters PH | 2002 | Int J Gynecol Cancer2002，12，： | 1 |
| 17 | Apolipoprotein A-V:a novel apolipoprotein associated with an early phase of liver regeneration显示文摘 | Van der Vliet HN Sammelsm MG Leegwater AC Levels JH Reitsma PH Boers W | 2001 | J Biol Chem2001，276，44： | 1 |
| 18 | Neural consequences of environmental enrichment 显示文摘 | Van PH Kempermann G Gage FH | 2000 | Nat Neurosci2000，1，3： | 1 |
| 19 | The efficacy of statin monotherapy uptitration versus switching to ezetimibe/simvastatin: results of the EASEGO study 显示文摘 | Roeters van Lennep HW Liem AH Dunselman PH | 2008 | Curr Med Res Opin2008，24，3： | 1 |
| 20 | Osteoporosis is not a risk factor for the development of nonunion : A cohort nes- ted case-control study 显示文摘 | van Wunnik BP Weijers PH van Helden SH | 2011 | Injury2011，42，12： | 1 |
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