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| 1 | Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients显示文摘AIM: To analyze the correlation between cytokineinduced killer (CIK) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. METHODS: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model. RESULTS: The survival time of gastric cancer patients was longer after CIK cells adoptive immunotherapy than after chemotherapy (χ 2 = 10.907, P = 0.001). The median survival time of gastric cancer patients was also longer after CIK cells adoptive immunotherapy than after chemotherapy (49 mo vs 27 mo, P < 0.05). The 2- and 5-year survival rates of gastric cancer patients were significantly higher after CIK cells adoptive immunotherapy than after chemotherapy (73.5% vs 52.6%, 40.4% vs 23.9%, P < 0.05). A significant difference was observed in the survival curve for patients who received CIK cells adoptive immunotherapy (0, 1-10, 11-25, and over 25 frequencies) (χ 2 = 14.534, P = 0.002). The frequencies of CIK cells adoptive immunotherapy were significantly related with the decreasing risk of death in gastric cancer patients after adjustment for sex and age of the patients, tumor stage and relapse (HR = 0.54, 95% CI: 0.36-0.80) when the first stage Cox model was used to define the subjects who remained alive beyond 36 mo as survivors. However, no correlation was observed between the frequencies of death in CIK cells adoptive immunotherapy and the risk of gastric cancer patients (HR = 1.09, 95% CI: 0.63-0.89) when the second stage Cox model was used to define the subjects who survived for more than 36 mo as survivors. CONCLUSION: The survival time of the gastric cancer patients treated with chemotherapy combined with CIK cells adoptive immunotherapy is significantly longer than that of the patients treated with chemotherapy alone and increasing the frequency of CIK cells adoptive immunotherapy seems to benefit patients more. | Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States | 2010 | World Journal of Gastroenterology2010，16，48： | 82 |
| 2 | METAMORPHIC MECHANISMSAND THEIR CONFIGURATION MODELS显示文摘The concept of metamorphic mechanisms is presented, configuration models and configuration transformations relating to a set of new matrix operations are discussed and proposed. The configuration of a metamorphic mechanism reflects the connectivity change in the mechanism during motions which results in mobility change and presents the characteristics of the mechanism which is discussed in various applications particularly in decorative artifacts. The characteristics is further investigated with mobility analysis. | Dai Jiansheng (Department of Mechanical Engineering, School of Physical Sciences and Engineering, King’s College, University of London,Strand,London WC2R 2LS, United kingdom) Zhang Qixian (Robotics Research Institute,Beijing University of Aeronautics and | 2000 | Chinese Journal of Mechanical Engineering2000，13，3： | 61 |
| 3 | 关于未来制造业的战略思考显示文摘“未来制造业”这个课题始于1995年,得到美国国家科学基金(NSF)资助,其目的是为美国的制造业主提供一个大致的指导性的框架,使之在不断发展的全球竞争的商务环境中走向成功。分析了未来制造业在全球市场环境下的特征,指出在新的复杂商业环境中,未来制造企业将会因为具有对顾客与全球市场的反应力等6项特质而获成功,并就制造企业的创新、知识供应链、变革管理诸方面进行了讨论。 | Jay Lee(United Technology Research Center) | 1999 | 中国机械工程1999，10，4： | 33 |
| 4 | Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-nave patients显示文摘AIM: To determine whether adding vitamin D, a potent immunomodulator, improves the hepatitis C virus (HCV) response to antiviral therapy. METHODS: Seventy-two consecutive patients with chronic HCV genotype 1 were randomized into two groups: the treatment group (n = 36, 50% male, mean age 47 ± 11 years) received Peg-α-2b interferon (1.5 μg/kg per week) plus ribavirin (1000-1200 mg/d) together with vitamin D3 (2000 IU/d, target serum level > 32 ng/mL), and the control group (n = 36, 60% male, mean age 49 ± 7 years) received identical therapy without vitamin D. HCV-RNA was assessed by realtime polymerase chain reaction (sensitivity, 10 IU/mL). The sustained virologic response (SVR) was defined as undetectable HCV-RNA at 24 wk post-treatment. RESULTS: Clinical characteristics were similar in both groups. The treatment group had a higher mean bodymass index (27 ± 4 kg/m2 vs 24 ± 3 kg/m2, P < 0.01), viral load (50% vs 42%, P < 0.01), and fibrosis score (> F2: 42% vs 19%, P < 0.001) than the controls. At week 4, 16 (44%) treated patients and 6 (17%) controls were HCV-RNA negative (P < 0.001). At week 12, 34 (94%) treated patients and 17 (48%) controls were HCV-RNA negative (P < 0.001). At 24 wk post-treatment (SVR), 31 (86%) treated patients and 15 (42%) controls were HCV-RNA negative (P < 0.001). Viral load, advanced fibrosis and vitamin D supplementation were strongly and independently associated with SVR (multivariate analysis). Adverse events were mild and typical of Peg-α-2b/ribavirin. CONCLUSION: Adding vitamin D to conventional Peg-α-2b/ribavirin therapy for treatment-na■ve patients with chronic HCV genotype 1 infection significantly improves the viral response. | Saif Abu-Mouch Zvi Fireman Jacob Jarchovsky Abdel-Rauf Zeina Nimer Assy Liver Unit | 2011 | World Journal of Gastroenterology2011，17，47： | 29 |
| 5 | Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults显示文摘This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for Chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were recruited based on the SENIEUR protocol.Three sets of reference ranges were finally built applicable for the healthy young(19-44 years),middle-aged(45-64 years) and elder adults(≥65).Comparisons in parameters among the three cohorts showed that a statistically significant increase in CD16CD56+ NK cell was observed between the middle-aged and elder cohorts,whereas for the majority of the parameters,a significant decline was observed between the young and the middle-aged cohorts.Further results showed that inverse correlations were observed between the age and CD19+ B,CD3+ T,CD3+CD4+ T,CD4+CD45RA+CD62L+ nave T cell and CD4+CD28+/CD4+,while the positive one was identified between the age and the NK cell.These significant changes of the most of immune parameters provided evidence for immunosenescence.Notably,T cell activation markers of CD8+CD38+ and CD8+HLA-DR+ showed reverse trends of association with age,which provides a clue for further researches on the mechanisms underlying the paradoxical clinical presentation of the elder patients. | JIAO Yang1,QIU ZhiFeng1,XIE Jing1,LI DongJing2 & LI TaiSheng1 1 Department of Infectious Disease,Peking Union Medical College Hospital,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing,China 2 Department of Special Care Unit,Peking Union Medical College Hospital,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing,China | 2009 | Science China(Life Sciences)2009，52，7： | 20 |
| 6 | Intracellular compartmentation of CTP synthase in Drosophila显示文摘Compartmentation is essential for the localization of biological processes within a eukaryotic cell.ATP synthase localizes to organelles such as mitochondria and chloroplasts.By contrast,little is known about the subcellular distribution of CTP synthase,the critical enzyme in the production of CTP,a high-energy molecule similar to ATP.Here I describe the identification of a novel intracellular structure con-taining CTP synthase,termed the cytoophidium,in Drosophila cells.I find that cytoophidia are present in all major cell types in the ovary and exist in a wide range of tissues such as brain,gut,trachea,testis,accessory gland,salivary gland and lymph gland.In addition,I find CTP synthase-containing cytoophidia in other fruit fly species.The observation of compartmentation of CTP synthase now permits a broad range of questions to be addressed concerning not only the structure and function of cytoophidia but also the organization and regulation of CTP synthesis. | Ji-Long Liu Medical Research Council Functional Genomics Unit,Department of Physiology,Anatomy and Genetics,University of Oxford,Oxford,OX1 3QX,United Kingdom | 2010 | Journal of Genetics and Genomics2010，37，5： | 16 |
| 7 | Clinical features of nonalcoholic fatty liver disease-associated hepatocellular carcinoma显示文摘BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis, is a recognized risk factor for hepatocellular carcinoma (HCC). However, detailed analysis of the clinical features in patients with NAFLD and their association with HCC is lacking. This study aimed to update the clinical features of patients with NAFLD-associated HCC. DATA SOURCES: The clinical data of patients with NAFLD- associated HCC from 25 studies published between 1990 and 2010 in the Pubmed database were comprehensively reviewed. RESULTS: In a total of 169 patients with NAFLD-associated HCC, 72.8% were male. The median age at abnormal liver function tests and diagnosis of NAFLD and HCC was 60, 64 and 67 years, respectively. Most patients were obese (75%) and diabetic (59.8%), 32.3% had dyslipidemia, and 53% had hypertension. Nearly all patients (98.6%, 71/72) were complicated with at least one metabolic disorder. The majority (76%) of the HCC patients had a solitary tumor nodule, with the tumor size ranging from 0.8 to 20 cm in diameter (mean 3.4 cm). Most (61.1%) of the patients had moderately-differentiated HCC. In 40.2% of the patients, HCC occurred in the absence of cirrhosis. Among 130 patients, 57.7% underwent hepatectomy and 14.6% received liver transplantation. The mean follow-up of the treated patients for 25 months showed that 32.4% (24/74) died and 18.8% (9/48) had recurrence. CONCLUSIONS: Patients with NAFLD-associated HCC are usually accompanied with metabolic disorders. Regular surveillance in patients with NAFLD for HCC is necessary, especially for elderly men with metabolic syndrome. | Xiao-Yan Duan, Liang Qiao and Jian-Gao Fan Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China Storr Liver Unit at the Westmead Millennium Institute, the University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 16 |
| 8 | Endoscopic ultrasonography guided biliary drainage: Summary of consortium meeting, May 7^(th) , 2011, Chicago显示文摘Endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred procedure for biliary or pancreatic drainage in various pancreatico-biliary disorders. With a success rate of more than 90%, ERCP may not achieve biliary or pancreatic drainage in cases with altered anatomy or with tumors obstructing access to the duodenum. In the past those failures were typically managed exclusively by percutaneous approaches by interventional radiologists or surgical intervention. The morbidity associated was significant especially in those patients with advanced malignancy, seeking minimally invasive interventions and improved quality of life. With the advent of biliary drainage via endoscopic ultrasound (EUS) guidance, EUS guided biliary drainage has been used more frequently within the last decade in different countries. As with any novel advanced endoscopic procedure that encompasses various approaches, advanced endoscopists all over the world have innovated and adopted diverse EUS guided biliary and pancreatic drainage techniques. This diversity has resulted in variations and improvements in EUS Guided biliary and pancreatic drainage; and over the years has led to an extensive nomenclature. The diversity of techniques, nomenclature and recent progress in our intrumentation has led to a dedicated meeting on May 7 th , 2011 during Digestive Disease Week 2011. More than 40 advanced endoscopists from United States, Brazil, Mexico, Venezuela, Colombia, Italy, France, Austria, Germany, Spain, Japan, China, South Korea and India attended this pivotal meeting. The meeting covered improved EUS guided biliary access and drainage procedures, terminology, nomenclature, training and credentialing; as well as emerging devices for EUS guided biliary drainage. This paper summarizes the meeting's agenda and the conclusions generated by the creation of this consortium group. | Michel Kahaleh Everson LA Artifon Manuel Perez-Miranda Kapil Gupta Takao Itoi Kenneth F Binmoeller California Pacific Medical Center San Francisco CA 94115 United States Marc Giovannini | 2013 | World Journal of Gastroenterology2013，19，9： | 15 |
| 9 | Pharmacokinetics of radioimmunotherapeutic agent of direct labeling mAb ^(188)Re-HAb18显示文摘AIM: To labed Anti-hepatoma monoclonal antibody (mAb)fragment HAb18 F (ab')2 was labeled with 188 Re for thepharmacokinetic model of 188 Re-HAb18 F (ab')2 and toevaluate its pharmacokinetic parameters in hepatoma-bearing nude mice.METHODS: HAb18 F(ab')2 was directly labeled with 188Reusing 2-mercaptoethanol (2-ME) as reducing agents.Labeling efficiency and immunoreactivity of 188 Re-HAb18 F( ab')2 were evaluated by Whatman 3MM paperchromatography and live cell assay, respectively.Biodiatribution analysis was also conducted in nude micebearing human hepatoma in which animals were sacrificed atdifferent time points(1, 4, 18, 24 and 24h) after 188Re-HAb18F(ab' )2 was injected through tail-vein into hepatoma-bearingnude mice. The blood and radioactivity of organs and masswere measured. The concentrations of 188 Re-HAb18 F(ab')2were evaluated with a pharmacokinetic 3P97 software.RESULTS: The optimum labeling efficiency andimmunoreactive fraction were 91.7% and 0.78%,respectively. The parameters of 188Re-HAb18 F(ab')2 were:T1/2, 2.29h; Vd, 1.49 × 10-9L@ Bq- 1; AUC, 20.49 × 109Bq@ h@L-1 ;CL, 0.45 × 10-3L@ h- 1. 188Re- HAb18 F(ab')2 could locatespecially in hepatoma with high selective reactivity of HAb18F(ab')2. 188 Re-HAb18 F(ab')2 was mainly eliminated bykidney. The maximal tumor to blood ratio was at 48h, andmaximal tumor to liver ratio was at 18h.CONCLUTION: The pharmacokinetics of 188Re-HAb18 F(ab')2fit a I-compartment model. 188 Re-HAb18 F(ab')2 can beuptaken selectively at the hepatoma site. | Chao Lou Zhi-Nan Chen Hui-Jie Bian Department of Cell Engineering Research Centre,Jie Li,Department of Oral Cell Biology,Qingdu Hospital,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China Shou-Bo Zhou School of Biological Sciences,University of Manchester,Oxford Road,United Kingdom | 2002 | World Journal of Gastroenterology2002，8，1： | 14 |
| 10 | Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells显示文摘RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi... | Michael Gke, Michiyuki Kanai, Kathryn Lynch Devaney, and Daniel K. Podolsky Gastrointestinal Unit, Department of Medicine, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massa | 1998 | World Journal of Gastroenterology1998，4，3： | 14 |
| 11 | Data processing of small samples based on grey distance information approach显示文摘Data processing of small samples is an important and valuable research problem in the electronic equipment test. Because it is difficult and complex to determine the probability distribution of small samples, it is difficult to use the traditional probability theory to process the samples and assess the degree of uncertainty. Using the grey relational theory and the norm theory, the grey distance information approach, which is based on the grey distance information quantity of a sample and the average grey distance information quantity of the samples, is proposed in this article. The definitions of the grey distance information quantity of a sample and the average grey distance information quantity of the samples, with their characteristics and algorithms, are introduced. The correlative problems, including the algorithm of estimated value, the standard deviation, and the acceptance and rejection criteria of the samples and estimated results, are also proposed. Moreover, the information whitening ratio is introduced to select the weight algorithm and to compare the different samples. Several examples are given to demonstrate the application of the proposed approach. The examples show that the proposed approach, which has no demand for the probability distribution of small samples, is feasible and effective. | Ke Hongfa, Chen Yongguang & Liu Yi 1. Coll. of Electronic Science and Engineering, National Univ. of Defense Technology, Changsha 410073, P. R. China 2. Unit 63880, Luoyang 471003, P. R. China | 2007 | Journal of Systems Engineering and Electronics2007，18，2： | 13 |
| 12 | Valuing water quality in China:purpose,approach and policy显示文摘The economic valuation of water quality in a rapidly developing country such as China should be undertaken to determine when the benefits from rapid growth begin to exceed the costs from the same. The best approach is to ascertain the total economic valuation of the environmental resource. This includes all of the various uses of the resource, and even those values that are unconnected to individual use (e.g. natural and aesthetic values). A method known as contingent valuation (CV) is used to ascertain these forms of value. This approach is demonstrated here in an application to river water quality in the Beijing area. A CV study is reported in which Beijing area citizens reported an average willingness to pay about 1.3% of annual income in order to prevent further deterioration of river water quality. Aggregation over the representative population indicates that the perceived cost of further river quality deterioration is in the neighbourhood of USD 60 million. Such a measure provides some indication of the socially desired “stopping point”—— in the pursuit of economic growth at the expense of environmental quality. | Timothy Swanson,Brett Day,Susana Mourato Centre for Social and Economic Research on the Global Environment, Department of Economics, and School of Public Policy, University College London, Gower Street, London WC1E 6BT, United Kingdom | 1999 | Journal of Environmental Sciences1999，11，3： | 12 |
| 13 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 14 | Environmental Implications of Excessive Selenium: A Review显示文摘Selenium is a naturally occurring trace element that is nutritionally required in smallamounts but it can become toxic at concentrations only twice those required. The narrow mar-gin between beneficial and harmful levels has important implications for human activities thatincrease the amount of selenium in the environment. Two of these activities, disposal of fbssilfuel wastes and agricultural irrigation of arid, seleniferous soils, have poisoned fish andwildlife, and threatened public health at several locations in the United States. Research stud-ies of these episodes have generated a data base that clearly illustrates the environmental hazardof excessive selenium. It is strongly bioaccumulated by aquatic organisms and even slight in-creases in waterborne concentrations can quickly result in toxic effects such as deformed em-bryos and reproductive failure in wildlife. The selenium data base has been very beneficial indeveloping hazard assessment procedures and establishing environmentally sound water qualitycriteria. The two faces of selenium, required nutrient and Potent toxin, make it a particularlyimportant trace element in the health of both animals and man. Because of this paradox, envi-ronmental selenium in relation to agriculture, fisheries, and wildlife wiIl continue to raise im-POrtant land and water management issues for decades to come. If these issues are dealt withusing prudence and the available environmental selenium data base, adverse irnpacts to naturalresources andspublic health can be | A. DENNIS LEMLY(United States Forest Service, Southern Research Station, Coldwater Fisheries Research Unit, Department of Fisheries and Wildlife Sciences, Virginia Tech University, Blacksburg, VA 24061-0321, USA) | 1997 | Biomedical and Environmental Sciences1997，10，4： | 10 |
| 15 | Discovery and identification of Serum Amyloid A protein elevated in lung cancer serum显示文摘Two hundred and eighteen serum samples from 175 lung cancer patients and 43 healthy individuals were analyzed by using Surface Enhaced Laser Desorption/Ionization Time of Flight Mass Spectrome- try (SELDI-TOF-MS). The data analyzed by both Biomarker Wizard? and Biomarker Patterns? software showed that a protein peak with the molecular weight of 11.6 kDa significantly increased in lung cancer. Meanwhile,the level of this biomarker was progressively increased with the clinical stages of lung cancer. The candidate biomarker was then obtained from tricine one-dimensional sodium dodecyl sul- fate-polyacrylamide gel electrophoresis by matching the molecular weight with peaks on WCX2 chips and was identified as Serum Amyloid A protein (SAA) by MALDI/MS-MS and database searching. It was further validated in the same serum samples by immunoprecipitation with commercial SAA antibody. To confirm the SAA differential expression in lung cancer patients, the same set of serum samples was measured by ELISA assay. The result showed that at the cutoff point 0.446(OD value)on the Receiver Operating Characteristic (ROC) curve, SAA could better discriminate lung cancer from healthy indi- viduals with sensitivity of 84.1% and specificity of 80%. These findings demonstrated that SAA could be characterized as a biomarker related to pathological stages of lung cancer. | DAI SongWei1,2, WANG XiaoMin1,2, LIU LiYun1,2, LIU JiFu3, WU ShanShan3, HUANG LingYun1,2, XIAO XueYuan1,2 & HE DaCheng1,2 1 Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Beijing Normal University, Beijing 100875, China 2 Universities’ Confederated Institute of Proteomics, Beijing 100875, China 3 Department of Thoracic Surgery, General Hospital of Beijing Unit, PLA, Beijing 100500, China | 2007 | Science China(Life Sciences)2007，50，3： | 10 |
| 16 | Role of autophagy in liver physiology and pathophysiology显示文摘Autophagy is a highly conserved intracellular degradation pathway by which bulk cytoplasm and superfluous or damaged organelles are enveloped by double membrane structures termed autophagosomes. The autophago-somes then fuse with lysosomes for degradation of their contents, and the resulting amino acids can then recycle back to the cytosol. Autophagy is normally activated in response to nutrient deprivation and other stressors and occurs in all eukaryotes. In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma. In this review, I discuss the recent findings of autophagy with a focus on its role in liver pathophysiology. | Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States | 2010 | World Journal of Biological Chemistry2010，1，1： | 9 |
| 17 | Designation and Development of Central Towns: A Case Study of Shiyan | LIU Aihua, PhD, College of Resources and Environment, Graduate School of Chinese Academy of Sciences Post-doctor, College of Economy, Nankai University and Tianjin Urban Planning and Design Institute, Tianjin, P. R. China. Research area: region planning, integrated urban-rural planning. XIE Zhengguan, Professor, College of Resources and Environment, Graduate School of Chinese Academy of Sciences, Beijing, P. R. China. Research area: urban geography and urban planning. ZHENG Yangyang, Assistant Planner, ICON United, Beijing, P. R. China. Research area: urban geography and urban planning. | 2012 | China City Planning Review2012，21，1： | 8 |
| 18 | Equilibrium equations for nonlinear buckling analysis of drill-strings in 3D curved well-bores显示文摘With the development of drilling technology, the oil/gas well has evolved from its early vertical straight form to the inclined, horizontal, plane curved, or even 3D curved well-bore. Understanding of the buck- ling behavior of a drill-string in a well-bore is crucial for the success of a drilling operation. Therefore, equilibrium equations for analyzing the buckling behavior of a drill-string in a 3D curved well-bore are required. Based on Love’s equilibrium equations for a curved and twisted rod in space, a set of equi- librium equations for the nonlinear buckling analysis of a drill-string in a 3D curved well-bore are de- rived by introducing a radial constraint of the well-bore. The proposed formulae can account for the well curvature and tortuosity. Thus, it can be used to analyze the buckling behaviors of a drill-string constrained in a well-bore and subjected to axial compression, torsion at its upper end, and gravity simultaneously. It is worth noting that the existing equations in the literature for a drill-string in a straight and plane curved well-bore with a constant curvature are a special case of the proposed model. Thus, the present model can provide a theoretical basis for the nonlinear buckling analysis of a drill-string constrained in a 3D curved well-bore. | TAN MeiLan1 & GAN LiFei2 1 Faculty of Science, Jiangsu University, Zhenjiang 212013, China 2 94973 Unit in Hangzhou of Zhejiang Province, Hangzhou 310021, China | 2009 | Science China(Technological Sciences)2009，52，3： | 7 |
| 19 | Optimization design study of low-Reynolds-number high-lift airfoils for the high-efficiency propeller of low-dynamic vehicles in stratosphere显示文摘Aerodynamic performance of low-Reynolds-number high-lift airfoil makes a great impact on designing a high-efficiency propeller for low-dynamic vehicles in stratosphere. At high altitude,low-Reynolds-number airfoils are supposed to have high lift-drag ratio or high endurance factor at cruising attack angle along with good stall characteristics. To design such a high-performance low-Reynolds-number high-lift airfoil,the paper established a hierarchical multi-objective optimization platform by combing direct search optimization algorithm EXTREM and airfoil flow field solver XFOIL to automatically and quickly calculate aerodynamic performance function of airfoil by computer. It provides an effective solution to multi-point design problem of low-speed low-Reynolds-number airfoil. It can be seen from the results of three typical optimization examples,the new airfoil E387_OPT2,FX63-137_OPT2 and S1223_OPT2 based on hot low-Reynolds-number high-lift airfoils (Eppler 387 airfoil,Wortmann FX63-137 airfoil and S1223 airfoil) can meet the optimization design requirements and have very good aerodynamic characteristics in both design state and non-design state. Thus,the applicability and effectiveness of hierarchical multi-objective optimization platform are verified. | MA Rong1, ZHONG BoWen2 & LIU PeiQing1 1 Key Laboratory of Fluid Mechanics, Ministry of Education, Institute of Fluid Mechanics, School of Aeronautical Science and Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100191, China 2 Department of Aerospace Science, School of Engineering, Cranfield University, MK43 0AL, United Kingdom | 2010 | Science China(Technological Sciences)2010，53，10： | 7 |
| 20 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
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