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| 1 | 五个月短程化疗及六个月全程间歇方案治疗菌阳肺结核的临床对照研究显示文摘目的考核利福喷丁(L)的疗效;缩短疗程或全程间歇以减少用药次数;观察全程应用吡嗪酰胺(Z)对疗效及毒副反应的影响。方法以利福平(R)为对照,采用5个月疗程方案(Ⅰ组2SHRZ/3R2H2Z2,Ⅱ组2SHRZ/3L1H2Z2)、6个月全间歇方案(Ⅲ组2S3H3R3Z3/4L1H2Z2,Ⅳ组2S3H3R3Z3/4L1H2E2),观察Z的全程应用结果,巩固期以乙胺丁醇(E)为对照。366例初治菌阳肺结核随机分入以上4组。结果(1)339例完成疗程者中329例治疗成功,满疗程时痰菌阴转率Ⅰ~Ⅳ组分别为970%、941%、1000%、972%。X线病灶有效率依序为960%、976%、1000%和944%。5个月组与6个月组空洞关闭率分别为77%及76%。各组相互比较均无显著性差异(P>0.05),未见严重副作用。(2)305例完成3年随访,Ⅰ、Ⅱ、Ⅲ、Ⅳ组细菌学加X线复发分别为2、3、6和3例。结论本研究结果进一步证明L是长效、高效、安全、便于督导的新药;巩固期用Z无必要;现有基本药物合理联用有可能缩短疗程为5个月,值得进一步研究。 | National Cooperative Group On Clinical Study of Pulmonary Tuberculosis (Report prepared by Chu Naihui , Yan Biya, Zhu Lizhen). Beijing Tuberculosis and Thoracic Tumor Institute, Beijing 101149 | 1998 | 中华结核和呼吸杂志1998，21，7： | 26 |
| 2 | 全间歇短程化疗方案治疗新发涂阳肺结核的远期疗效分析显示文摘目的世界银行贷款中国结核病控制项目首次将全间歇短程化疗(短化)方案[2H3R3Z3S3(E3)/4H3R3]应用于国家结核病控制规划,取得了满意的近期疗效。为评价方案的有效性,特进行远期效果观察。方法对12个项目省、自治区56个示范县1992年全年登记的新发涂阳患者,在治愈后2年进行了结核分支杆菌涂片检查,以了解细菌学复发情况。结果4400例治愈患者经痰涂片检查,发现135例痰菌复阳,复发率为3.1%。结论本研究与国内外短化每日疗法与继续期间歇的6个月短化方案相比,其复发率相近。证明本方案治愈率高(复发率在3%左右),不失为一个可优先推广应用于国家结核病规划的化疗方案之一。 | Tuberculosis Control Project Cooperation Group.Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149 | 1997 | 中华结核和呼吸杂志1997，20，3： | 21 |
| 3 | Molecular phylogeny of Pneumocystis based on 5.8S rRNA gene and the internal transcribed spacers of rRNA gene sequences显示文摘To clarify the phylogenetic relationships and species status of Pneumocystis, the 5.8S rRNA gene and the internal transcribed spacers (ITS, 1 and 2) of Pneumocystis rRNA derived from rat, gerbil and human were amplified, cloned and sequenced. The genetic distance matrix of six Pneumocystis species compared with other fungi like Taphrina and Saccharomyces indicated that the Pneumocystis genus contained multiple species including Pneumocystis from gerbil. The phylogenetic tree also showed that Pneumocystis from human and monkey formed one group and four rodent Pneumocystis formed another group. Among the four members, Pneumocystis wakefieldiae was most closely related to Pneumocystis murina and Pneumocystis carinii, and was least related to gerbil Pneumocystis. | LI ZiHui1,2, FENG XianMin1, LU SiQi1, ZHANG Fan1, WANG FengYun1 & HUANG Song1 1 Department of Pathogenic Biology, Capital Medical University, Beijing 100069, China 2 Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101100, China | 2008 | Science China(Life Sciences)2008，51，5： | 9 |
| 4 | 2005年广州市结核病现况抽样调查显示文摘目的了解广州市结核病的流行现状及危害程度,评价广州市结核病防治措施,为制定广州市2006至2010年结核病防治规划提供科学依据。方法采用整群随机和按人口比例抽样方法,抽样人口比例为1:158。广州市应有流行病学调查点为24个,平均每个调查点的应检人数为1656人。对调查点0~14岁儿童进行结核菌素纯蛋白衍生物试验,询问其卡介苗接种史并检查卡痕;对结核菌素反应≥10 mm,或虽<10 mm 但伴有水疱等强反应的儿童和≥15岁应检人口进行 X 线胸透;对疑有肺结核症状者、X 线胸透有异常阴影及已知肺结核患者均拍摄胸部 X 线片;对 X 线胸透异常及疑有肺结核症状者进行痰涂片和痰培养检查,对培养阳性的标本进行菌种鉴定。结果广州市活动性肺结核患病率为201/10万,涂阳肺结核患病率为33/10万,菌阳肺结核患病率为43/10万;14岁以下儿童中未发现活动性肺结核患者,15~50岁组活动性肺结核患病率为72.5/10万~176.8/10万,80岁以上达高峰,以老年男性最高(2341/10万);已知活动性肺结核、涂阳和菌阳肺结核分别为35.0%(28/80)、61.5%(8/13)和47.1%(8/17);初治活动性肺结核、涂阳和菌阳肺结核分别为81.3%(65/80)、69.2%(9/13)和58.8%(10/17);55岁以上组的复治活动性肺结核患者占80.0%。结论广州市的结核病患病率仍较高,老年菌阳肺结核仍较多。 | Guangzhou Technique Steering Group of the Epidemiological Sampling Survey for Tuberculosis | 2007 | 中华结核和呼吸杂志2007，30，6： | 6 |
| 5 | ABSTRACTS OF CHINESE MEDICAL LITERATURE显示文摘 | Lu Gen, Feng Jiemei,Huang Jian, et al. Guangzhou Institute of Tuberculosis, Guangzhou 510180. Chin J Tuberculosis & Respirat Dis 1995 | 1995 | Chinese Medical Journal1995，，6： | 5 |
| 6 | 西班牙结核病人的治疗完成和病死率现状显示文摘目的:确定结核病人的完成治疗情况,并分析中断治疗和病死的相关因素。方法:在 SEPAR 结核病和呼吸道感染工作组成员工作的地区,对 1999 年 6 月 1 日至2000 年5 月 31 日期间开始接受治疗的结核病人进行前瞻性队列分析。利用 logistic 回归对与中断治疗和病死相关的诸因素进行了研究,并计算各因素的比数比(OR)及其 95%CI。结果:本项研究涉及 76 家医院 142 名医生提供的1515 例病例信息。82%的病人完成了全部治疗,14%中断治疗,5%死亡,0.5%治疗失败,8.7%由于迁出或其它原因中断了治疗。与中断治疗有关的变量是静脉吸毒(IVDU)(OR=6.00,95%CI:2.59-13.89和移民(OR=8.57,95%CI:3.78-19.45);性别、年龄、无家可归、监禁、DOT或住院治疗与中断治疗无关。病人病死率的预报因素有酗酒(OR=6.38,95%CI:2.09-19.48);HIV 感染(OR=7.08,95%CI:2.08-29.15)和年龄大于 64 岁(OR=10,95%CI:2.9-34.07),性别、吸毒、无家可归、DOT 和住院治疗与病人的病死率无关。结论:在发达国家应对吸毒和移民病人采用 DOT,另外,需要对酗酒、HIV 感染、年龄大于64 岁者实施严格监督以降低其病死率。 | J.A.Caylà J.A.Caminero R.Rey N.Lara X.Vallès H.Galdós-Tangüis Working Group on Completion of Tuberculosis Treatment in Spain 姜世闻 | 2004 | 结核与肺部疾病杂志2004，7，2： | 2 |
| 7 | In: National workbook of TB control显示文摘 | Ministry of Health Detection of Tuberculosis Cases | 1999 | Beijing: Ministry of Health1999，，25： | 1 |
| 8 | Thirteenth Report of the Medical Research Council Working Party on Tuberculosis of the Spine显示文摘 | A 15-year assessment of controlled trials of the management of tuberculosis of the spine in Korea and Hong Kong | 1998 | J Bone Joint Surg Br1998，80，3： | 1 |
| 9 | A 15-year assessmet of controlled trials of tuberculosis the management of the spine in Korea and Hog Kong显示文摘 | Medical Research Council Working Party on Tuberculosis of spine | 1996 | J Bone Joint Surg(Br)1996，27，： | 1 |
| 10 | A double- blind pla-cebo- controlled clinical trial of three anti-tuberculosis chemo-prophylaxis regimens in patients with silicosis in Hong Kong显示文摘 | Hong Kong Chest Service Tuberculosis Research Centre Ma-dras British Medical Research Council | 1992 | Am Rev Respir Dis1992，145，： | 1 |
| 11 | The effect of tuberculosis control in China 显示文摘 | China Tuberculosis Control Collaboration | 2004 | Lancet2004，364，： | 1 |
| 12 | Treatment guidelines for latent tuberculosis infection显示文摘 | Prevention Committee of the Japanese Society for Tuberculosis Treatment Committee of the Japanese Society for Tuberculosis | | 0，，： | 1 |
| 13 | The effect of tuberculosis control in China显示文摘 | China Tuberculosis Control Collaboration | 2004 | Lancet2004，364，9432： | 1 |
| 14 | Treatment guidelines for latent tuberculosis intection 显示文摘 | Prevention Committee of the Japanese Society for Tuberculosis Treat- ment Committee of the Japanese Society for Tuberculosis | 2014 | Kekkaku2014，89，1： | 1 |
| 15 | The fifth national tuberculosis epidemiologieal sampling survey in 2010 显示文摘 | The fifth National tuberculosis epidemiological sampling survey technical steering group the fifth national tuberculosis epidemiologieal sampling survey office | 2012 | Defense tuberculosis in the magazine2012，34，8： | 1 |
| 16 | The Progress Report of the World Bank Loaned China Tuberculosis Control Project显示文摘The progress of the World Bank loaned TB control project implemented from the second quarter of 1991 to the fourth quarter of 1993 was reported in this paper. In the past three years, 737 counties of the 12 provinces with the popula- | Zhao Fengzeng et al. Tuberculosis Control Project Office of the MOPH, Beijing 100025. | 1995 | Chinese Medical Journal1995，，9： | 1 |
| 17 | Chemotherapy and management of tuberculosis in the United Kingdom :recommendations 1998 显示文摘 | Joint Tuberculosis Committee of the British Thoracic Society | 1998 | Thorax1998，53，7： | 1 |
| 18 | Colonoscopic study of 50 显示文摘 | Shah S Thomas V Mathan M patients with colonic tuberculosis | 1992 | Gut1992，33，： | 1 |
| 19 | Efficacy of various durations of isoniazid preventive therapy for tuberculosis:five years follow-up in the IUAT trial显示文摘 | International Union Against Tuberculosis | 1982 | Bull World Health Organ1982，60，4： | 1 |
| 20 | Revised international definitions in tuberculosis control 显示文摘 | World Health Organization Internafional Union Against Tuberculosis and Lung Disease Royal Netherlands Tuberculosis Association | 2001 | Int J Tuberc Lung Dis2001，5，3： | 1 |
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