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| 1 | Liver fibrosis in non-alcoholic fatty liver disease-diagnostic challenge with prognostic significance显示文摘Non-alcoholic fatty liver disease(NAFLD) is the mostcommon liver disease in the Western world, with a prevalence of 20%. In a subgroup of patients, inflammation, ballooning degeneration of hepatocytes and a varying degree of fibrosis may develop, a condition named non-alcoholic steatohepatitis. Advanced liver fibrosis(stage F3) and cirrhosis(stage F4) are histologic features that most accurately predict increased mortality in both liver-related and cardiovascular diseases. Patients with advanced fibrosis or cirrhosis are at risk for complications such as hepatocellular carcinoma and esophageal varices and should therefore be included in surveillance programs. However, liver disease and fibrosis are often unrecognized in patients with NAFLD, possibly leading to a delayed diagnosis of complications. The early diagnosis of advanced fibrosis in NAFLD is therefore crucial, and it can be accomplished using serum biomarkers(e.g., the NAFLD Fibrosis Score, Fib-4 Index or BARD) or non-invasive imaging techniques(transient elastography or acoustic radiation force impulse imaging). The screening of risk groups, such as patients with obesity and/or type 2 diabetes mellitus, for NAFLD development with these non-invasive methods may detect advanced fibrosis at an early stage. Additionally, patients with a low risk for advanced fibrosis can be identified, and the need for liver biopsies can be minimized. This review focuses on the diagnostic challenge and prognostic impact of advanced liver fibrosis in NAFLD. | Per Stal | 2015 | World Journal of Gastroenterology2015，21，39： | 15 |
| 2 | p53polymorphic variants at codon72and the outcome of therapy in ran-domized breast cancer patients显示文摘 | Wegman P Stal O Askmalm MS | 2006 | Pharmacogenet Ge-nomics2006，16，5： | 1 |
| 3 | Variation in IRF6con-tributes to nonsyndromic cleft lip and palate显示文摘 | Blanton SH Cortez A Stal S | 2005 | Am J Med Genet A2005，137，3： | 1 |
| 4 | Microstructure of model cermets with high Mo or W content显示文摘 | LINDAHL P GUSTAFSON P ROLANDER U STALS L ANDREN H O | 1999 | International Journal of Refractory Metals & Hard Materials1999，17，6： | 1 |
| 5 | Distribution of extracellular carbohydrates in three intertidal mudflats in West-ern Europe 显示文摘 | de Brouwer J F C De Deekere E M G T Stal L J | 2003 | Estuarine Coastal and Shelf Science2003，56，： | 1 |
| 6 | Pattern-Oriented Software Architecture显示文摘 | Douglas Schmidt Michael Stal | 2000 | Patterns for Concurrent and Networked Objects2000，2，： | 1 |
| 7 | Optical emission spectroscopy of the plasma during CVD diamond growth with nitrogen addition显示文摘 | Vandevelde T Nesladek M Quaeyhaegens C Stals L | 1996 | Thin solid films1996，，： | 1 |
| 8 | Exopolysaccharide production by the epipelic diatom Cylindrotheca closterium:effects of nutrient conditions显示文摘 | Staats N Stal L J Mur L R | 2000 | J Exp Mar Biol Ecol2000，2491，： | 1 |
| 9 | MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cel s显示文摘 | Welch C Chen Y Stal ings RL | | 0，，34： | 1 |
| 10 | Optical emission spectroscopy of the plasma during microwave CVD of diamond thin films with nitrogen addition and relation to the thin film morphology显示文摘 | Vandevelde T Nesladek M Quaeyhaegens C Stals L | 1997 | Thin solid films1997，，14： | 1 |
| 11 | p53 expression and the result of adjuvant therapy of breast cancer显示文摘 | Stal O Stenmark AM Wingren S | 1995 | Acta Oncol1995，34，6： | 1 |
| 12 | Reported foodbome outbreaks due to noroviruses in Belgium:The link between food and patient investigations in an international context显示文摘 | Baert L Uyttendaele M Stals A | 2009 | demiol Infect2009，137，3： | 1 |
| 13 | Food utilisation by coastal fish assemblages in rocky and soft bottoms on the Swedish west coast: Inference for identification of essential fish habitats显示文摘 | STAL J PIHL L WENNHAGE H | 2007 | Estuarine Coastal and Shelf Science2007，71，： | 1 |
| 14 | Reported foodborne outbreaks due to noroviruses in Belgium: the link between food and patient investigations in an international context显示文摘 | Baert L Uyttendaele M Stals A etal | 2009 | Epidemiol Infect2009，137，3： | 1 |
| 15 | The use of phosphomannose-isomerase as a selectable marker to recover transgenic maize plants via agrobacterium tronsformation显示文摘 | Nerotto D Jolley M Beer S stal | 2000 | Plant cell reports2000，，19： | 1 |
| 16 | Activat-ion of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients显示文摘 | Perez-Tenorio G Stal O Southeast Sweden Breast Cancer Group | 2002 | Br J Cancer2002，86，4： | 1 |
| 17 | Overexpression of MDM2 in acute childhood lymphoblastic leukemia显示文摘 | Gustafsson B Stal O Gustafsson B | 1998 | Pediatr Hematol Oncol1998，15，6： | 1 |
| 18 | Nonsyndromic cleft lip with or without cleft palate: evidence of linkage to BCL3 in 17 multigenerational families显示文摘 | Mulliken JB Stal S | 1995 | Am J Hum Genet1995，57，2： | 1 |
| 19 | C-erbB-2 overexpression and survival in early onset breast cancer显示文摘 | Agrup M Stal O Olsen K | 2000 | Breast Cancer Res Treat2000，63，1： | 1 |
| 20 | Abnormal palatopharyngeal muscle morphology in sleep disordered breathing 显示文摘 | LINDMAN R STAL P S | 2002 | J Neurol Sci2002，195，： | 1 |
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