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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs显示文摘Objective:Since December 2019,an outbreak of corona virus disease 2019(COVID-19)occurred in Wuhan,and rapidly spread to almost all parts of China.This was followed by prevention programs recommending Chinese medicine(CM)for the prevention.In order to provide evidenee for CM recommendations,we reviewed ancient classics and human studies.Methods:Historical records on prevention and treatment of infections in CM classics,clinical evidence of CM on the prevention of severe acute respiratory syndrome(SARS)and H1N1 in flue nza,and CM preve ntion programs issued by health authorities in China since the COVID-19 outbreak were retrieved from differe nt databases and websites till 12 February,2020.Research evide nee in eluded data from clinical trials,cohort or other population studies using CM for preventing contagious respiratory virus diseases.Results:The use of CM to prevent epidemics of infectious diseases was traced back to ancient Chinese practice cited in Huangdi's Internal Classic(Huang Di Nei Jing)where preventive effects were recorded.There were 3 studies using CM for prevention of SARS and 4 studies for H1N1 influenza.None of the participants who took CM contracted SARS in the 3 studies.The infection rate of H1N1 in flue nza in the CM group was significantly lower than the non-CM group(relative risk 0.36,95%confidence interval 0.24-0.52;n=4).For prevention of COVID-19,23 provinces in China issued CM programs.The main principles of CM use were to tonify qi to protect from external pathoge ns,disperse wind and discharge heat,and resolve damp ness.The most frequently used herbs in eluded Radix astragali(Huangqi),Radix glycyrrhizae(Gancao),Radix saposhnikoviae(Fangfeng),Rhizoma Atractylodis Macrocephalae(Baizhu),Lonicerae Japonicae Flos(Jinyinhua),and Fructus forsythia(Lianqiao).Conclusions:Based on historical records and human evidenee of SARS and H1N1 influenza prevention,Chinese herbal formula could be an alternative approach for prevention of COVID-19 in high-risk population.Prospective,rigorous population studies are warranted to confirm the potential preventive effect of CM. | LUO Hui TANG Qiao-ling SHANG Ya-xi LIANG Shi-bing YANG Ming Nicola Robinson LIU Jian-ping | 2020 | Chinese Journal of Integrative Medicine2020，26，4： | 61 |
| 3 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 4 | Occurrences of Permian radiolarians in central and eastern Nei Mongol(Inner Mongolia) and their geological significance to the Northern China Orogen显示文摘The Zhesi (Jisu) Formation of the Middle Per- mian in Nei Mongol (Inner Mongolia) was commonly con- sidered to be a shallow marine sequence. Here I report the radiolarians found in the argillite bed of that formation in Zhesi and Xilinhot areas. This fact indicates a deep marine sedimentary facies persisted during the Middle Permian, and suggests that the ocean between the North China Block and Siberian Craton was not closed until the Late Guadalupian. The suture of this two blocks is probably extends along the Linxi ophiolite belt, south of the Hegenshan ophiolite belt. | SHANG Qinghua Nanjing Institute of Geology and Paleontology,Chinese Academy of Sciences,Nanjing 210008,China Institute of Vertebrate Paleontology and Paleoanthropology,Chinese Academy of Sciences,Beijing 100044,China | 2004 | Chinese Science Bulletin2004，49，24： | 44 |
| 5 | Efects of physical and chemical characteristics of surface sediments in the formation of shallow lake algae-induced black bloom显示文摘Surface sediments are closely related to lake black blooms. The dissolved oxygen(DO) distribution and its penetration depth in surface sediments as well as the migration and transformation of redox sensitive elements such as Fe and S at the sediment-water interface are important factors that could influence the formation of the black bloom. In this study, dredged and undredged sediment cores with diferent surface properties were used to simulate black blooms in the laboratory. The Micro Profiling System was employed to explore features of the DO and ∑ H2 S distribution at the sediment-water interface. Physical and chemical characteristics in sediments and pore waters were also analyzed. The results showed that sediment dredging efectively suppressed the black blooms. In the undredged treatment, DO penetration depth was only 50 μm. Fe2+concentrations, ∑ H2 S concentrations, and ∑ H2 S production rates were remarkably higher in surface sediments and pore waters compared to control and dredged treatments. Furthermore, depletion of DO and accumulation of Fe2+and ∑ H2 S in surface sediments and pore waters provided favorable redox environments and necessary material sources for the blooms. The study results proved that physical and chemical characteristics in surface sediments are important factors in the formation of the black bloom, and could provide scientific guidance for emergency treatment and long-term pre-control of black blooms. | Qiushi Shen Cheng Liu Qilin Zhou Jingge Shang Lei Zhang ChengXin Fan | 2013 | Journal of Environmental Sciences2013，25，12： | 43 |
| 6 | An Interdisciplinary Nutrition Support Team Improves Clinical and Hospitalized Outcomes of Esophageal Cancer Patients with Concurrent Chemoradiotherapy显示文摘 | Ming-Hua Cong Shu-Luan Li Guo-Wei Cheng Jin-Ying Liu Chen-Xin Song Ying-Bing Deng Wei-Hu Shang Di Yang Xue-Hui Liu Wei-Wei Liu Shi-Yan Lu Lei Yu | 2015 | Chinese Medical Journal2015，，22： | 41 |
| 7 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 8 | EMT-associated microRNAs and their roles in cancer stemness and drug resistance显示文摘Epithelial-to-mesenchymal transition(EMT)is implicated in a wide array of malignant behaviors of cancers,including proliferation,invasion,and metastasis.Most notably,previou studies have indicated that both cancer stem-like properties and drug resistance were associated with EMT.Furthermore,microRNAs(miRNAs)play a pivotal role in the regulation of EMT phenotype,as a result,some miRNAs impact cancer stemness and drug resistance.Therefore,understanding the relationship between EMT-associated miRNAs and cancer stemness/drug resistance is beneficial to both basic research and clinical treatment.In this review,we preliminarily looked into the various roles that the EMT-associated miRNAs play in the stem-like nature of malignant cells.Then,we reviewed the interaction between EMT-associated miRNAs and the drugresistant complex signaling pathways of multiple cancers including lung cancer,gastric cancer,gynecologic cancer,breast cancer,liver cancer,colorectal cancer,pancreatic cancer,esophageal cancer,and nasopharyngeal cancer.We finally discussed the relationship between EMT,cancer stemness,and drug resistance,as well as looked forward to the potential applications of miRNA therapy for malignant tumors. | Guangtao Pan Yuhan Liu Luorui Shang Fangyuan Zhou Shenglan Yang | 2021 | Cancer Communications2021，41，3： | 46 |
| 9 | Danshen: a phytochemical and pharmacological overview显示文摘Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic diterpenoids, water-soluble phenolic acids, and other constituents, which have showed various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-tumor, anti-atherogenesis, and anti-diabetes. This article intends to provide novel insight information for further development of Danshen, which could be of great value to its improvement of utilization. | MEI Xiao-Dan CAO Yan-Feng CHE Yan-Yun LI Jing SHANG Zhan-Peng ZHAO Wen-Jing QIAO Yan-Jiang ZHANG Jia-Yu | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 43 |
| 10 | The Global Stratotype Section and Point (GSSP) for the boundary between the Capitanian and Wuchiapingian Stage (Permian)显示文摘 | Yugan Jin Shuzhong Shen Charles M. Henderson Xiangdong Wang Wei Wang Yue Wang Changqun Cao Qinghua Shang | 2006 | Episodes2006，29，4： | 39 |
| 11 | 基于SPOT遥感数据的甘蔗叶面积指数反演和产量估算显示文摘利用SPOT遥感数据进行甘蔗叶面积指数LAI反演,建立最佳NDVI-LAI反演模型,同时结合不同生育期甘蔗叶面积指数的时序变化规律,建立各生育期甘蔗叶面积指数LAI与产量的相关关系,得到甘蔗叶面积指数LAI-产量最佳估产模型。在验证甘蔗叶面积指数LAI的基础上,利用遥感反演的甘蔗叶面积指数LAI进行甘蔗单产估算。结果表明:甘蔗叶面积指数LAI与NDVI之间存在显著的正相关关系,全生育期二者的相关性最高,以二次函数模型拟合效果最佳,决定系数R2为0.842 9。将遥感数据反演得到的平均叶面积指数LAI数据代入甘蔗叶面积LAI-产量模型得到全县平均单产,与统计数据相比,相对误差仅为2.6%。说明该模型具有较好的估产效果,可以为甘蔗区域估产提供重要参考。 | 何亚娟 潘学标 裴志远 马尚杰 Heather McNirn Jiali Shang | 2013 | 农业机械学报2013，44，5： | 36 |
| 12 | Role of Notch signaling in regulating innate immunity and inflammation in health and disease显示文摘表明小径的槽口从果蝇被保存到哺乳动物并且极其涉及发展过程。在免疫系统,槽口发信号在中央、外部的淋巴的器官调整 T 和 B 细胞开发的多重步,这被建立了。相对槽口在淋巴细胞开发发信号的很好记录的角色,更少在调整 myeloid 系开发和功能对它的角色被知道,特别在尖锐、长期的发炎的上下文。在这篇评论文章,我们将描述在最近的年期间积累在天生的有免疫力、煽动性的回答支持槽口小径的一个关键规章的角色并且为煽动性的混乱的致病和治疗讨论如此的规定的潜在的含意的证据。 | Yingli Shang Sinead Smith Xiaoyu Hu | 2016 | Protein & Cell2016，7，3： | 40 |
| 13 | A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root显示文摘Cells of eukaryotic multicellular organisms have inherent heterogeneity.Recent advances in single-cell gene expression studies enable us to explore transcriptional regulation in dynamic development processes and highly heterogeneous cell populations.In this study,using a high-throughput single-cell RNA-sequencing assay,we found that the cells in Arabidopsis root are highly heterogeneous in their transcriptomes.A total of 24 putative cell clusters and the cluster-specific marker genes were identified.The spatial distribution and temporal ordering of the individual cells at different developmental stages illustrate their hierarchical structures and enable the reconstruction of continuous differentiation trajectory of root development.Moreover,we found that each root cell cluster exhibits distinct patterns of ion assimilation and hormonal responses.Collectively,our study reveals a high degree of heterogeneity of root cells and identifies the expression signatures of intermediate states during root cell differentiation at single-cell resolution.We also established a web server(http://gffzz3806e4fd3a914718h6pn0x60kf0kp6wpv.ffgz.tsg.suse.edu.cn/rootatlas/)to facilitate the use of the datasets generated in this study. | Tian-Qi Zhang Zhou-Geng Xu Guan-Dong Shang Jia-Wei Wang | 2019 | Molecular Plant2019，12，5： | 37 |
| 14 | Wnt3a signaling promotes proliferation,myogenic differentiation,and migration of rat bone marrow mesenchymal stem cells显示文摘瞄准:调查在增长,迁居,和老鼠骨髓的生肌的、脂肪形成的的区别上发信号的无翼相关的 MMTV 集成地点 3A (Wnt3a ) 的效果间充质的干细胞(rMSC ) 。方法:主要 MSC 被孤立并且从 Sprague-Dawley 老鼠有教养、由流动血细胞计数描绘。老鼠 L 房间是有 Wnt3a cDNA 的 transfected,并且调节了包含活跃 Wnt3a 蛋白质的媒介被准备。房间增长被房间计数和 5-bromodeoxyuridine 加入试金评估。rMSC 的迁居被使用 transwell 迁居和创伤愈合试金执行。在 rMSC 的生肌的、脂肪形成的的区别被轻显微镜学,免疫荧光,和 RT-PCR 在生肌的或脂肪形成的介绍以后在不同时间点检验。结果:发信号的 Wnt3a 导致了 beta-catenin 原子易位并且在 rMSC 激活 Wnt 小径。面对 Wnt3a, rMSC 比控制房间更快增殖了,使他们的区别潜在。而且,发信号的 Wnt3a 在在生肌的是有教养的以后导致了表示 rMSC 的 desmin 和肌浆球蛋白重链中的 2.62% 个和 3.76% 中等。生肌的区别基因,包括的 Pax7, MyoD, Myf5, Myf4,和肌浆蛋白在,在 Wnt3a 处理以后被激活。在另一方面, Wnt3a 在 rMSC 禁止了脂肪形成的区别通过下面 CCAAT/enhancer-binding 蛋白质高山的调整表示哈(C/EBPalpha ) 并且 peroxisome 激活 proliferator 的受体鲸鱼群妈(PPARgamma ) 。而且, Wnt3a 支持了 rMSC 的迁居能力。结论:结果显示在 rMSC 表明罐头 induce 生肌的区别的那 Wnt3a。发信号的 Wnt3a 也涉及增长的规定和 rMSC 的移植。这些结果能在人为基于房间的织物修理提供一个合理基础。 | Yan-chang SHANG Shu-hui WANG Fu XIONG Cui-ping ZHAO Fu-ning PENG Shan-wei FENG Mei-shan LI YongLI Cheng ZHANG | 2007 | Acta Pharmacologica Sinica2007，28，11： | 34 |
| 15 | Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase显示文摘目的: 调查 resveratrol (RSV ) 是否能改进非酒精的脂肝疾病(NAFLD ) 并且发现可能的 mechanism.Methods : 老鼠喂了一本高脂肪的食谱与 RSV.The 肝组织学被对待 observed.Hyperinsulinemic euglycemic clamp 被执行估计胰岛素敏感度。胖累积在 HepG2 细胞被导致,并且细胞与 激活RSV.AMP 的蛋白质激酶( AMPK )被对待磷酸化层次在动物学习和细胞 study.Results 两个都被决定:老鼠喂了一本高脂肪的食谱发达腹的肥胖, NAFLD ,和抗胰岛素性(红外),它显著地到 10 星期 RSV administration.RSV 处理被改进在与葡萄糖和胰岛素的高集中被孵化的 HepG2 细胞的阻止的 triacylglycerol ( TG )累积。在活体内和在试管内研究证明 RSV 处理能支持 AMPK 的磷酸化,它在这学习,压制了 2 脂肪的开始基因表情,贡献 NAFLD 和 IR.Conclusion 的改进:结果由减少 TG 累积和改善红外显示了那, RSV 能保护肝免受 AMPK 的 NAFLD.The 激活的伤害涉及 mechanism.RSV 为阻止或对待 NAFLD 和红外相关的新陈代谢的混乱有治疗学的潜力。 | Jing SHANG Lu-lu CHEN Fang-xi XIAO Hui SUN Hong-cheng DING Hu XIAO | 2008 | Acta Pharmacologica Sinica2008，29，6： | 32 |
| 16 | Beyond hypoxia: Occurrence and characteristics of black blooms due to the decomposition of the submerged plant Potamogeton crispus in a shallow lake显示文摘Organic matter-induced black blooms(hypoxia and an offensive odor) are a serious ecosystem disasters that have occurred in some large eutrophic shallow lakes in China. In this study, we investigated two separate black blooms that were induced by Potamogeton crispus in Lake Taihu, China. The main physical and chemical characteristics, including color- and odor-related substances, of the black blooms were analyzed. The black blooms were characterized by low dissolved oxygen concentration(close to 0 mg/L), low oxidation-reduction potential, and relatively low pH of overlying water. Notably higher Fe2+and∑S2-were found in the black-bloom waters than in waters not affected by black blooms. The black color of the water may be attributable to the high concentration of these elements, as black FeS was considered to be the main substance causing the black color of blooms in freshwater lakes. Volatile organic sulfur compounds, including dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide, were very abundant in the black-bloom waters. The massive anoxic degradation of dead Potamogeton crispus plants released dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide, which were the main odor-causing compounds in the black blooms. The black blooms also induced an increase in ammonium nitrogen and soluble reactive phosphorus levels in the overlying waters. This extreme phenomenon not only heavily influenced the original lake ecosystem but also greatly changed the cycling of Fe, S, and nutrients in the water column. | Qiushi Shen Qilin Zhou Jingge Shang Shiguang Shao Lei Zhang Chengxin Fan | 2014 | Journal of Environmental Sciences2014，26，2： | 33 |
| 17 | A Survey: Several Technologies of Non-Orthogonal Transmission for 5G显示文摘One key advantage of 4G OFDM system is the relatively simple receiver implementation due to the orthogonal resource allocation.However,from sum-capacity and spectral efficiency points of view,orthogonal systems are never the achieving schemes.With the rapid development of mobile communication systems,a novel concept of non-orthogonal transmission for 5G mobile communications has attracted researches all around the world.In this trend,many new multiple access schemes and waveform modulation technologies were proposed.In this paper,some promising ones of them were discussed which include Non-orthogonal Multiple Access(NOMA),Sparse Code Multiple Access(SCMA),Multi-user Shared Access(MUSA),Pattern Division Multiple Access(PDMA)and some main new waveforms including Filter-bank based Multicarrier(FBMC),Universal Filtered Multi-Carrier(UFMC),Generalized Frequency Division Multiplexing(GFDM).By analyzing and comparing features of these technologies,a research direction of guiding on future 5G multiple access and waveform are given. | TAO Yunzheng LIU Long LIU Shang ZHANG Zhi | 2015 | China Communications2015，12，10： | 31 |
| 18 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 19 | Seasonal variation of potential denitrification rates of surface sediment from Meiliang Bay, Taihu Lake, China显示文摘The regulatory effects of environmental factors on denitrification were studied in the sediments of Meiliang Bay, Taihu Lake, in a monthly sampling campaign over a one-year period. Denitrification rates were measured in slurries of field samples and enrichment experiments using the acetylene inhibition technique. Sediment denitrification rates in inner bay and outer bay ranged from 2.8 to 51.5 nmol N2/(g dw (dry weight)·hr) and from 1.5 to 81.1 nmol N2/(g dw·hr), respectively. Sediment denitrification rates were greatest in the spring and lowest in the summer and early autumn, due primarily to seasonal differences in nitrate concentration and water temperature. For each site, positive and linear relationships were regularly observed between denitrification rate and water columnn itrate concentration. Of various environmental factors on denitrification that we assessed, nitrate was determined to be the key factor limiting denitrification rates in the sediments of Meiliang Bay. In addition, at the two sites denitrification rates were also regulated by temperature. The addition of organic substrates had no significant effect on denitrification rate, indicating that sediment denitrification was not limited by organic carbon availability in the sediments. Nitrate in the water column was depleted during summer and early autumn, and this suppressed effective removal of nitrogen from Taihu Lake by denitrification. | Jicheng Zhong, Chengxin Fan, Guofeng Liu, Lei Zhang, Jingge Shang, Xiaozhi GuState Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. | 2010 | Journal of Environmental Sciences2010，22，7： | 29 |
| 20 | Adaptive Nonlinear Optimal Compensation Control for Electro-hydraulic Load Simulator显示文摘Directing to the strong position coupling problem of electro-hydraulic load simulator(EHLS),this article presents an adaptive nonlinear optimal compensation control strategy based on two estimated nonlinear parameters,viz.the flow gain coefficient of servo valve and total factors of flow-pressure coefficient.Taking trace error of torque control system to zero as control object,this article designs the adaptive nonlinear optimal compensation control strategy,which regards torque control output of closed-loop controller converging to zero as the control target,to optimize torque tracking performance.Electro-hydraulic load simulator is a typical case of the torque system which is strongly coupled with a hydraulic positioning system.This article firstly builds and analyzes the mathematical models of hydraulic torque and positioning system,then designs an adaptive nonlinear optimal compensation controller,proves the validity of parameters estimation,and shows the comparison data among three control structures with various typical operating conditions,including proportion-integral-derivative(PID) controller only,the velocity synchronizing controller plus PID controller and the proposed adaptive nonlinear optimal compensation controller plus PID controller.Experimental results show that systems' nonlinear parameters are estimated exactly using the proposed method,and the trace accuracy of the torque system is greatly enhanced by adaptive nonlinear optimal compensation control,and the torque servo system capability against sudden disturbance can be greatly improved. | Yao Jianyong Jiao Zongxia Shang Yaoxing Huang Cheng | 2010 | Chinese Journal of Aeronautics2010，23，6： | 29 |
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