|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Seed dormancy in Carex canescens, regional differences and ecological consequences显示文摘 | Sch T W Milberg P | 1997 | Oikos1997，78，： | 1 |
| 5 | Anastomotic leak- age follow low anterior resection results of a standard ized di- agnostic and the rap eutic approach显示文摘 | Eckm ann C Kujath P Sch iedeck TH | 2004 | Int J ColorectalD is2004，19，2： | 1 |
| 6 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Müller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
| 7 | Marginalized particle filters for mixed linear/nonlinear state-space models显示文摘 | SCH?N T GUSTAFSSON F NORDLUND P | 2005 | IEEE Transactions on Signal Processing2005，53，7： | 1 |
| 8 | Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis显示文摘 | Licht P Lsch A Dittrich R | 1998 | Hum Reprod Update1998，4，： | 1 |
| 9 | Microcirculation and excretory function of the liver under conditions of carbon dioxide pneumoperitoneum显示文摘 | Leister l Schüler P Vollmar B | 2004 | Surg Endosc2004，18，9： | 1 |
| 10 | Novel xylose dehydrogenase in the ha- lo-philic archaeon Haloarcula marismortut显示文摘 | Johnsen U Sch?nheit P | 2004 | J Bacteriol2004，186，： | 1 |
| 11 | Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation显示文摘 | Al-Sady B Ni W Kircher S Sch?fer E Quail P H | 2006 | Molecular cell2006，23，3： | 1 |
| 12 | Using the international 10-20 EEG system for positioning of transcranial magnetic stimulation 显示文摘 | HERWIG U SATRAPI P SCH? NFELDT-LECUONA C | 2003 | Brain Topogr2003，16，2： | 1 |
| 13 | Clinical impact of trabeetedin (ecteinascidin -743 ) in advanced/metastatic soft tissue sarcoma显示文摘 | Schǒffski P Dumez H Wolter P | 2008 | Expert Opin Pharmacother2008，9，9： | 1 |
| 14 | A Model for Exponential Decaying Inventory显示文摘 | Ghare P M Sch rader G F | 1963 | Journal of Engineering1963，14，： | 1 |
| 15 | Cadmium-induced changes in antioxidant systems,hydrogen peroxide content,and differentiation in scots pine roots显示文摘 | Schützendübel A Schwanz P Teichmann T | 2001 | Plant Physiol2001，127，： | 1 |
| 16 | HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA显示文摘 | Fritsche P Seidler B Schüler S | 2009 | Gut2009，58，10： | 1 |
| 17 | Phase Ⅱ study of biweekly cetuximab in combination with irinotecan as second-line treatment in patients with platinum-resistant gastro-oesophageal cancer显示文摘 | Schnnemann K R Yilmaz M Bjerregaard J K Nielsen K M Pfeiffer P | 2012 | Eur J Cancer2012，48，： | 1 |
| 18 | The CD40/CD154 receptor/ligand dyad显示文摘 | Sch(o)nbeck U Libby P | 2001 | Cell Mol Life Sci2001，58，1： | 1 |
| 19 | Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome显示文摘 | Jopling CL Schütz S Sarnow P | 2008 | Cell Host Microbe2008，4，1： | 1 |
| 20 | Fertilizing commercial forest species in Southern Africa:research progress and problems(Part 1)显示文摘 | Herbert M A Schnau A P G | 1989 | South African Forestry Journal1989，151，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员