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| 1 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 2 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 3 | Non-mutagenicity of KBT-1585, a novel ester of ampicillin显示文摘 | Yamabe S Mccoy EC Rosenkranz HS | 1984 | Chemotherapia1984，3，： | 2 |
| 4 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 5 | Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL显示文摘 | Dichgans M Markus HS Salloway S | 2008 | Lancet Neurol2008，7，4： | 1 |
| 6 | Primary cardiac angiosarcoma evaluated with contrast two-dimensional and real-time three-dimensional echocardiography 显示文摘 | Yang HS Sengupta S Umland MM | 2008 | Eur J Echocardiogr2008，9，5： | 1 |
| 7 | Prognostic factors in osteosarcomas显示文摘 | Bentzen SM Poulsen HS Kaae S | 1988 | Cancer1988，62，： | 1 |
| 8 | Contralateral Gen-itofemoral sympathetic nerved dischange increases Follow-ing ipsilateral testicular torsion显示文摘 | Otcu S Durakogugil M Orer HS | 2002 | Urol Res2002，30，5： | 1 |
| 9 | Neurobehavioral outcome following minor head injury:a three-center study显示文摘 | Levin HS Mattis S Ruff RM | 1987 | J Neurosurg1987，66，： | 1 |
| 10 | In vitro chemopreventive effects of plant polysaccharides(Aloe barbadensis Miller,Lentinus edodes,Ganoderma lucidum and Coriolus versicolor )显示文摘 | Kim HS Kacew S Lee BM | 1999 | Carcinogenesis1999，20，8： | 1 |
| 11 | Contralateral genitofemoral sympathetic nerve discharge increases following ipsilateral testicular torsion显示文摘 | Otcu S Durakogugil M Orer HS | 2002 | Urol Res2002，30，5： | 1 |
| 12 | Survey and mechanism of skin depigmenting and lightening agents 显示文摘 | Parvez S Kang M Chung HS | 2006 | Phytother Res2006，20，11： | 1 |
| 13 | Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system 显示文摘 | Yokoi K Zhang HS Kachi S Balaggan KS Yu Q Guschin D | 2007 | Mol Ther2007，15，11： | 1 |
| 14 | Perceived stress and physio psycho social status of nursing students during their initial period of clinical practice:The effect of coping behaviors显示文摘 | Sheu S Lin HS Hwang SL | 2002 | Int J Nurs Stud2002，39，2： | 1 |
| 15 | Contralateral genitofemoral sympathetic nerve discharge increases following ipsilateral testicular torsion 显示文摘 | Otcu S Durakogugil M Orer HS | 2002 | Urol Res2002，80，： | 1 |
| 16 | Survey and mechanism of skin depigmenting and lightening agents 显示文摘 | Parvez S Kang M Chung HS | 2006 | Phytother Res2006，20，11： | 1 |
| 17 | Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes显示文摘 | Park BW Park S Park HS | 2012 | Breast Cancer Res Treat2012，133，2： | 1 |
| 18 | The comparative ef ects of mesoporous silica nanoparticles and col oidal silica on inflammation and apoptosis显示文摘 | Lee S Yun HS Kim SH | | 0，，35： | 1 |
| 19 | Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AM-PK activity in HCT116 colon cancer显示文摘 | Kim HS Wannatung T Lee S | 2012 | Apoptosis2012，17，7： | 1 |
| 20 | Automatic detection of residential buildings using LiDAR data and muhispectral imagery显示文摘 | Awra Ngjeb M Ra V Anbak Hs H M raser C S | 2010 | ISPRS Journal of Photogramme- try and Remote Sensing2010，65，5： | 1 |
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