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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Environmental impact and management of phosphogypsum显示文摘 | Hanan Tayibi Mohamed Choura Félix A. López Francisco J. Alguacil Aurora López-Delgado | 2009 | Journal of Environmental Management2009，，8： | 2 |
| 3 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 4 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 5 | Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin 1and annexin A2as differentially regulated显示文摘 | Domínguez F Garrido-Gómez T López JA | 2009 | Hum Reprod2009，24，： | 1 |
| 6 | Solving an assignment-selection problem with verbal information and using genetic algorithms显示文摘 | Herrera F López E Mendana C | 1999 | Europearn Journal of Operational Research1999，119，2： | 1 |
| 7 | Therapeutic guidelines on ulcerative colitis:a GRADE methodology based effort of GETECCU显示文摘 | Gomollón F García-López S Sicilia B | | 0，，02： | 1 |
| 8 | The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth显示文摘 | Pez F Dayan F Durivault J | | 0，，5： | 1 |
| 9 | Multiresidue determination of organophosphorus and organochlorine pesticides in human biological fluids by capillary gas chromatography显示文摘 | Pitarch E Lpez F J Serrano R | 2001 | J Anal Chem2001，369，： | 1 |
| 10 | Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans显示文摘 | Navarro-Martínez M D García-Cánovas F Rodríguez-López J N | 2006 | Journal of Antimicrobial Chemotherapy2006，57，6： | 1 |
| 11 | Matrix-effects of vegetable commodities in electron-capture detection applied to pesticide multiresidue analysis显示文摘 | Egea González F J Hernandez Torres M E Almansa López E | 2002 | J Chromatogr A2002，966，12： | 1 |
| 12 | Protective role of the interleukin 33 rs3939286 gene polymorphism in the development of subclinical atherosclerosis in rheumatoid arthritis patients显示文摘 | López Mejías R Genre F Remuzgo Martínez S | 2015 | PLoS One2015，10，01： | 1 |
| 13 | Monolayered amniotic membrane transplantation as a palliative treatment for bullous keratopathy 显示文摘 | L o pez Ferrando N Celis S a nchez J Gonz a lez Del Valle F | 2004 | Arch Soc Esp Oftalmol2004，79，1： | 1 |
| 14 | A molecular isotopic study of ^13 C-enriched organic matter in evaporitic deposits: recognition of CO2 limited ecosystems 显示文摘 | SCHOUTEN S HARTGERS W A LO PEZ J F | 2001 | Organic Geochemistry2001，32，： | 1 |
| 15 | The HIF-l-inducible lysyl oxi- dase activates HIF-1 via the akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth显示文摘 | Pez F Dayan F Durivauh J | 2011 | Cancer Res2011，71，5： | 1 |
| 16 | Pregnancy and Kidney Transplantation,Triple Hazard?Current Concepts and Algorithm for Approach of Preconception and Perinatal Care of the Patient With Kidney Transplantation显示文摘 | L Pez L F Mart Nez C J Casta Eda D A | 2014 | Transplantation Proceedings2014，46，9： | 1 |
| 17 | Prophenoloxidase from brown shrimp (Penaeus californiensis) hemocytes显示文摘 | Gollas-Galván T Hernández-López J Vargas-Albores F | 1999 | Comp Biochem Physiol1999，122，： | 1 |
| 18 | Chemical characterization of the aroma of Grenaehe Rose wines: aroma extract dilution analysis, quantitative determination, and sensory reconstitution studies显示文摘 | Ferreira V Orti n N Escudero A Lo pez R Cacho J F | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 19 | Magnetic properties of large ising clusters 显示文摘 | F Aguilera - Granja J L Morn - L pez J M Montejano - Carrizales | 1995 | Surface Science1995，326，12： | 1 |
| 20 | Mean flow and turbulence structure of open-channel flow through non-emergent vegetation显示文摘 | López F García M H | 2001 | Journal of Hydraulic Engineering2001，127，5： | 1 |
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