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| 1 | Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients显示文摘BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)loss.AIM To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs therapy.METHODS Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in monotherapy.Hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were eligible.Patients with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were excluded.HBsAg and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six weeks.HBsAg loss rate was evaluated in both groups.Adverse events were recorded in both groups.The kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression model.RESULTS Sixty-five patients were enrolled,61%receiving tenofovir and 33%entecavir.Thirty-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA group.After matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not change.Eight(22%)patients discontinued Peg-IFN due to adverse events.The HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA group.CONCLUSION The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to NA therapy.Side effects of Peg-IFN can limit its use in clinical practice. | Teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 2 | Assessing heavy metal sources in agricultural soils of an European Mediterranean area by multivariate analysis 显示文摘 | C Mico^* L Recatala M Peris J Sanchez | 2006 | Chemosphere2006，65，： | 1 |
| 3 | In vitro release of transforming growth factor-beta I from gelatin microparticles encapsulated in biodegradable,injectable oligo(poly(ethylene glycol) fumarate) hydrogels显示文摘 | Holland TA Tabata Y Micos AG | 2003 | J Control Release2003，91，3： | 1 |
| 4 | Contraindications of video-assisted thoracoscopic surgical lobectomy and determinants of conversion to open显示文摘 | Hanna JM Berry MF D'mico TA | 2013 | J Thorac Dis2013，5，： | 1 |
| 5 | Enhanced modified moving average analysis of T- wave alternans using a curve matching method : a simulation study 显示文摘 | CUESTA F MICO T P ABOY M | 2009 | Medi- cal & Biological Engineering & Computing2009，47，3： | 1 |
| 6 | Serum cystatin C and microalbuminuria in the detection of vascular and renal damage in early stages显示文摘 | Lopez GJ Sacristan EB Mico M | | 0，，05： | 1 |
| 7 | Enriched environment, nitric oxide production and synaptic plasticity prevent the aging-dependent impairment of spatial cognition 显示文摘 | Da' mico ASL Paglia N | 2004 | Mol Aspects Med2004，25，12： | 1 |
| 8 | 查看详情显示文摘 | Granero L Mico V Zalevsky Z Garcia J | | 0，，： | 1 |
| 9 | 查看详情显示文摘 | Granero L Zzlevsky Z Mico V | | 0，，： | 1 |
| 10 | Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats显示文摘 | Esther Berrocoso M. Dolores Benito Juan A. Mico | 2007 | Psychopharmacology2007，，1： | 1 |
| 11 | Assessing heavy metal sources in agricultural soils of an European Mediterranean area by multivariate analysis 显示文摘 | Mico C Recatala L Perls M | 2006 | Chemosphere2006，65，： | 1 |
| 12 | Biodegradation of Inorganic Components in Paper Documents:Formation of Calcium Oxalate Crystals as a Consequence of Aspergillus Terreus Thom Growth显示文摘 | Pinzari F Zotti M Mico A D | 2010 | International Biodeterioration & Biodegradation2010，64，6： | 1 |
| 13 | 哥本哈根世界最佳城市的模样显示文摘英国生活杂志Monocle选出2008年世界20个最佳城市,丹麦首都哥本哈根以生活质素高和重视环保等因素排列榜首。德国慕尼黑和日本东京分别排第2和3位。该杂志赞扬哥本哈根城市设计优良、交通便利、基建完善、现代化建筑物和高档餐厅随处可见,还有重视环保。其中重视环保的特色,为哥本哈根增加不少分数,所以由前年的第2位升至去年的首位。今年12月,一场事关地球未来的国际谈判——《联合国气候变化公框架公约》第十五次缔约方会议(简称COP15)将在哥本哈根举行。本刊特约记者袁雪对话哥本哈根多位权威人士,诉说一个真实的模范城市。 | 雷发林 袁雪 Mico 林嘉澍 STB | 2009 | 商务旅行2009，0，3： | 1 |
| 14 | Assessing heavy metalsources in agricultural soils of an EuropeanMediterranean area bymultivariate analysis显示文摘 | Mico C Recatala L Peris M | 2006 | Chemosphere2006，65，： | 1 |
| 15 | Assessing heavy metal sources in agricultural soils of an European Mediterranean area by multivariate analysis 显示文摘 | MICO C RECATAL L PERIS M | 2006 | Chemosphere2006，65，5： | 1 |
| 16 | 查看详情显示文摘 | Mico V Zalevsky Z Garcia-Martinez P | | 0，，： | 1 |
| 17 | Intraocular Tessure after extimer laser myopic refractive surgery 显示文摘 | MONTES MICO R CHARMAN W N | 2001 | Ophthal Physiol Opt2001，21，： | 1 |
| 18 | Video-assisted thoracic surgery lobectomy: report of CALGB 39802-A prospective, multi-institution feasibility study显示文摘 | Swanson SJ Herndon JE 2nd D~-mico TA | 2007 | J Clin Oncol2007，25，31： | 1 |
| 19 | Assessing heavy metal sources in agricultural soilsof an EuropeanMediterranean area bymultivariate analysis 显示文摘 | Mico C Recatala L Peris M | 2006 | Chemosphere2006，65，5： | 1 |
| 20 | Efficacy of mediastinal lymph node dissection during lobectomy for lung cancer by thora-coscopy and thoracotomy显示文摘 | A mico TA Niland J Mamet R | 2011 | Ann Thoracic Surg2011，9，5： | 1 |
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