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您的检索式：作者名="mark f.mccarty"
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| 1 | 膳食甘氨酸的健康保护潜力显示文摘谷胱甘肽是一种重要的清除型抗氧化剂,可以抵抗过氧化氢的促炎信号传导。细胞谷胱甘肽水平的提高可能在预防和治疗由氧化应激引起的各种疾病上具有广泛的用途。在膳食中添加N-乙酰半胱氨酸就是出于该目的。添加甘氨酸是否能促进谷胱甘肽的合成,为此我们利用PubMed文献数据库对相关文献进行了综述。结果发现动物机体组织中甘氨酸的水平低于甘氨酸的谷胱甘肽合成酶米氏常数(Km)。当甘氨酸供应量太少不足以维持正常的谷胱甘肽合成速度时,组织中γ-谷氨酰半胱氨酸的浓度就会升高,从而导致尿液中其替代代谢产物5-L-氧代脯氨酸的含量增多。这种代谢产物在素食者和其他食用蛋白水平相对低的膳食的人尿液中水平增加的事实强烈表明,膳食中的甘氨酸能够限制饮食正常的人体内谷胱甘肽的合成。此外,多项动物研究报道,日粮中添加甘氨酸可以增加机体组织中谷胱甘肽的含量。甘氨酸是卟啉、嘌呤、肌酸、肌氨酸和胆汁盐生物合成的前体物质,是甘氨酸门控氯离子通道的激动剂和N-甲基-D-天冬氨酸受体的协同激动剂。它可抑制蛋白质糖化,提高丙酮酸盐(一种有效的过氧化氢清除剂)在肝脏中的合成。补充甘氨酸具有改善内皮功能、预防心脏肥大、辅助控制代谢综合征、预防糖尿病并发症、抑制炎症、保护肝脏和促进有效睡眠的潜力。因此,我们有必要进行临床研究以评估甘氨酸对谷胱甘肽水平和各种疾病的影响。 | 唐彩琰(译) 邵建忠(审) mark f.mccarty james h.o'keefe james j.dinicolantonio | 2018 | 国外畜牧学(猪与禽)2018，38，9： | 3 |
| 2 | 膳食甘氨酸的健康保护潜力(续1)显示文摘上期回顾:上期主要介绍了膳食甘氨酸对谷胱甘肽合成的调节作用、健康保护潜力以及甘氨酸与代谢综合征的关系等内容.
5甘氨酸的抗炎作用
巨噬细胞、白细胞和库普弗细胞都表达甘氨酸门控氯离子通道,在这些细胞中,甘氨酸发挥着超极化作用,其通过电压敏感的钙离子通道抑制钙的内流,从而下调它们的促炎活性。 | 唐彩琰 王晶晶 Mark F.McCarty James H.O'Keefe James J.DiNicolantonio | 2018 | 国外畜牧学(猪与禽)2018，38，10： | 0 |
| 3 | Could zinc dipicolinate be used to“smuggle”zinc into prostate cancer cells?显示文摘Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion,it loses its capacity to import zinc while undergoing malignant transformation.This exclusion of zinc may be necessary for the viability of prostate cancer,as measures which increase the intracellular zinc content of prostate cancers lead to cell death,oxidative stress,and a marked reduction in ATP,suggestive of mitochondrial damage.The anti-fungal drug clioquinol,which can act as a zinc ionophore,can markedly slow the growth of human prostate cancer in nude mice,and has been proposed as a clinical therapy for prostate cancer.However,clioquinol is currently only available as a topical agent,as it was linked to subacute myelo-optic neuropathy with oral use.A more practical option for promoting zinc transport may be offered by the nutraceutical zinc dipicolinate,a stable chelate in which four coordination positions of zinc are occupied by two molecules of the tryptophan metabolite picolinic acid.Zinc dipicolinate is a highly effective supplemental source of zinc that has been shown to be more potent than soluble zinc salts for alleviating the symptoms of acrodermatitis enteropathica,a genetic zinc deficiency disorder reflecting homozygous loss of functional ZIP4 zinc importers in enterocytes.This suggests that the zinc dipicolinate complex is sufficiently stable and lipophilic to transfer zinc across cellular membranes.If so,it may have potential for“smuggling”zinc into prostate cancer cells.Hence,cell culture and rodent studies to evaluate the impact of zinc dipicolinate on human prostate cancer are warranted. | Mark F.McCarty Simon Iloki Assanga Lidianys Lewis Lujan | 2020 | Journal of Cancer Metastasis and Treatment2020，6，1： | 0 |
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