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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Institutional ownership and monitoring: Evidence from financial misreporting显示文摘 | Natasha Burns Simi Kedia Marc Lipson | 2010 | Journal of Corporate Finance2010，，4： | 2 |
| 3 | Comparison Between Angiography and Fractional Flow Reserve Versus Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging for Determining Lesion Significance in Patients With Multivessel Coronary Disease显示文摘 | Michael Ragosta Andrew H. Bishop Lewis C. Lipson Denny D. Watson Lawrence W. Gimple Ian J. Sarembock Eric R. Powers | 2007 | The American Journal of Cardiology2007，，7： | 2 |
| 4 | Multifocal atrial tachy cardia clinical associaa - tion and significanec显示文摘 | Lipson MJ | 1970 | Circulation1970，67，397： | 1 |
| 5 | Hematoporphyrin derivative: a new aid for endoscopic detection of malignant disease 显示文摘 | Lipson RL Baldes EJ Olsen AM | 1961 | J Thorac Cardiovasc Surg1961，42，： | 1 |
| 6 | Senve-to 10-year outcome of decompressive surgery for degenerative lumbar spinal stenosis显示文摘 | Katz JN Lipson SJ Chang LC | 1996 | Spine1996，21，： | 1 |
| 7 | Discovery of recurrent KIF5B-RET fusions and other targetable alterations from clinical NSCLC specimens 显示文摘 | Capelletti M Lipson D Otto G | 2012 | J Clin Oncol2012，30，15： | 1 |
| 8 | Associations between spinal deformity and outcomes after decompression for spinal stenosis 显示文摘 | Frazier DD Lipson SJ Fossel AH | 1997 | Spine1997，22，17： | 1 |
| 9 | Lumbar lamineciomy alone or with instrumented or noninstrumented arthrodesis in degenerative lumbar spinal stenosis显示文摘 | Katz JN Lipson SJ Lew RA | 1997 | Spine1997，22，10： | 1 |
| 10 | Hematoporphyrin deriv- ative:a new aid for endoscopic detection of malignant disease显示文摘 | Lipson RL Baldes E J Olsen AM | 1961 | J Thorac Cadiovasc Surg1961，42，： | 1 |
| 11 | Redefining treatment in COPD:new directions in bronchodilator therapy显示文摘 | Lipson D A | | 0，，02： | 1 |
| 12 | Subwavelength confinement in an integrated metal slot waveguide on silicon 显示文摘 | Chela L Shakya J Lipson M | 2006 | Opt Lett2006，31，14： | 1 |
| 13 | Differentiating an- tidepressants of the future : efficacy and safety 显示文摘 | Rosenzweig - Lipson S Beyer CE Hughes ZA | 2007 | Pharmacol Ther2007，113，1： | 1 |
| 14 | Time-resolved study of raman gain in highly confined silicon-on-insulator waveguides显示文摘 | Xu Qianfan Almeida V R Lipson M | 2004 | Optics Express2004，12，19： | 1 |
| 15 | Seven to ten-yearoutcome of decompressive surgery for degenerative lumbar spinalstenosis显示文摘 | KATZ JN LIPSON SJ CHANG LC | 1996 | Spine1996，21，1： | 1 |
| 16 | Apical perfusion fraction as a predicter of short-term functional outcome following bilateral lung volume reduction surgery显示文摘 | Kotloff RM Hansen-Flashen J Lipson DA | 2001 | Chest2001，120，5： | 1 |
| 17 | Pregnancy,birth,and disability:women's health care experiences显示文摘 | Lipson JG Rogers JG | 2000 | Health Care Women Int2000，21，： | 1 |
| 18 | Lumbar Laminectomy alone or with instrumented or non - instrumented arthrodesis in degenerative lumbar spinal stenosis显示文摘 | Katz JN Lipson S J Liw RA | 1997 | Spine1997，22，5： | 1 |
| 19 | Seven to lO-year outcome of de compressive surgery for degenerative lumbar spinal steno- sis 显示文摘 | Katz J N Lipson S J Chang L C | 1996 | Spine1996，21，1： | 1 |
| 20 | Liquidity and Capital Structure显示文摘 | Lipson M L Mortal S | 2009 | Journal of Financial Markets2009，12，4： | 1 |
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