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| 1 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 2 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 3 | Methylglyoxal increase in uremia with special reference to snakebite-mediated acute renal failure 显示文摘 | Mukhopadhyay S Ghosh A Kar M | 2008 | Clin Chim Acta2008，391，12： | 1 |
| 4 | Transvaginal sonography, sonohysterography, and hysteroscopy for investigation of focal intrauterine lesions in women with recurrent postmenopausal bleeding after dilatation & curettage 显示文摘 | Karageyim Karsidag A Y Buyukbayrak E E Kars B | 2010 | Arch Gynecol Obstet2010，281，4： | 1 |
| 5 | Neuroendocrine pharmacology of stress显示文摘 | Gonzalo A Carrasco Louis D Van de Kar | 2003 | European Journal of Pharmacology2003，，1： | 1 |
| 6 | Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2YI and P2Y12 gene pol- ymorphisms显示文摘 | KAR R MEENA A YADAV B K | 2013 | Platelets2013，24，4： | 1 |
| 7 | Up-regulation of theproapoptotic caspase 2 splicing isoform by a can-didate tumor suppressor,RBM5显示文摘 | Fushimi K Ray P Kar A | 2008 | Proc Natl Acad SciUSA2008，105，15： | 1 |
| 8 | Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats显示文摘 | Tahiliani P Kar A | 2000 | Pharmacological Research2000，41，3： | 1 |
| 9 | Experimental unilateral sper-marie cord torsion:the effect of polypolymerase enzyme inhibitor on histopathological and biochemical changes in the early and late peri ods in the ipsilateral and contralateral testicles显示文摘 | Kar A Ozden E Yakupoglu YK | 2010 | Urology2010，76，2： | 1 |
| 10 | Treatment of peri-implantitis by the Vector system 显示文摘 | Karring ES Stavropoulos A Ellegaard B | 2005 | Clin Oral Im- plants Res2005，16，3： | 1 |
| 11 | Chemoprevention of mammary tumorigenesis and chemomodulation of the antioxidative enzymes and peroxidative damage in prepubertal Sprague Dawley rats by Biochanin A显示文摘 | Mishra P Kale RK Kar A | 2008 | Mol Cell Biochem2008，312，12： | 1 |
| 12 | Relativistically correct hole-boring and ion acceleration by circularly polarized laser pulses显示文摘 | A P L Robinson P Gibbon M Zepf S Kar R G Evans C Bellei | 2009 | Plasma Physics and Controlled Fusion2009，，2： | 1 |
| 13 | Texture feature matching methods for content based image显示文摘 | MAJUMDAR I KAR A CHATTEJI B N | 2007 | IETE Technical Review2007，24，4： | 1 |
| 14 | Use of acrylate-based liquid rubbers as toughening agents and adhesive property modifiers of epoxy resin 显示文摘 | Kar S Banthia A K | 2004 | Journal of Applied Polymer Science2004，92，6： | 1 |
| 15 | 显示文摘 | Wolker A C Kar A K Ji W | 1986 | Appl Phys Lett1986，48，11： | 1 |
| 16 | 显示文摘 | Molyneux S matsuda H Kar A K | 1993 | Nonlinear Opt1993，4，： | 1 |
| 17 | Thermoelastic interaction with energy dissipation in an infinitely extended thin platecontaining a circular hole显示文摘 | Kar A Kanoria M | 2006 | Far East Journal of Applied Mathematics2006，24，2： | 1 |
| 18 | Cross - entropy meas- ure of uncertain variables 显示文摘 | CHEN X W KAR S DAN A R | 2012 | Information Sciences2012，，201： | 1 |
| 19 | Methane hydrate formation and dissociation in oil-in-water emulsion显示文摘 | KAKATI H KAR S MANDAL A | 2014 | Energy&Fuels2014，28，7： | 1 |
| 20 | Five-year results of guided tissue regeneration in combination with deproteinized bovine bone (Bio-Oss) in the treatment of intrabony periodontal defects:a case series report显示文摘 | Karring T | 2005 | Clin Oral Investig2005，12，： | 1 |
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