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| 1 | 重组葡激酶与重组组织型纤溶酶原激活剂治疗急性心肌梗死的随机多中心临床试验显示文摘目的研究新型溶栓剂——重组葡激酶(r-Sak)治疗急性心肌梗死(AMI)的冠状动脉通畅率、临床疗效及安全性。方法本研究为多中心、随机、平行对照临床试验,入选发病12 h 内、年龄≤70岁、ST 段抬高的 AMI 患者,随机分为 r-Sak 组104例,给予 r-Sak 3 mg 静注,12 mg 于30 min 内静脉输注,总量15 mg;重组组织型纤溶酶原激活剂(rt-PA)组106例,8 mg 静注,42 mg 在90 min 内输注,总量50 mg。全部患者给予阿司匹林和静脉输注肝素,于用药90 min 行冠状动脉造影,对 TIMI 血流0~2级者行补救性 PCI。结果主要终点:用药90 min 冠状动脉通畅率(TIMI 血流2级或3级),r-Sak 组明显高于 rt-PA 组(77.8%比63.6%,P=0.0277),TIMI 3级者两组间差异无统计学意义(57.6%比48.5%,P=0.1929);1个月内死亡(8.7%比5.7%,P=0.3997)、非致死性再梗死(2.9%比3.8%,P=1.0000)、心肌缺血复发(8.7%比16.0%,P=0.1043)和复合临床终点(18.3%比21.7%,P=0.5345)两组间差异均无统计学意义。次要终点:r-Sak 组出血发生率(28.8%)与 rt-PA组(27.4%)比较,差异无统计学意义(P=0.8105),其中严重或威胁生命的出血,两组间差异亦无统计学意义(1.9%比3.8%),r-Sak 组脑出血1例(0.96%),rt-PA 组脑出血4例(3.85%)。无其他药物相关的严重不良反应及过敏反应发生。结论 r-Sak 是一种安全、有效的治疗 AMI 的溶栓药物,其疗效及安全性至少与 rt-PA 50 mg 相似。 | Collaborative Research Group of Reperfusion Therapy in Acute Myocardial Infarction | 2007 | 中华心血管病杂志2007，35，8： | 43 |
| 2 | 90分钟冠状动脉造影评价急性心肌梗塞血管开通及临床再通指标价值显示文摘通过经静脉溶栓开始后90分钟冠状动脉造影(CAG),观察国产尿激酶(天普洛欣,UKTP)静脉溶栓治疗急性心肌梗塞(AMI)血管开通疗效,并评价临床再灌注标准的判断价值如何。方法:从UKTP多中心治疗AMI1406例中,汇集其中所行冠状动脉造影(CAG)共124例资料。结果提示:(1)124例AMI患者,在溶栓开始后90分钟时的梗塞相关血管的血流达TIMIⅢ级者52例(41.9%)、Ⅱ级38例(30.7%),梗塞相关血管再开通率为72.6%;(2)溶栓距起病时间愈早,具有愈高的开通趋势,但差异无统计学意义;(3)以CAG为金标准,临床标准对血管开通判断敏感性为88%,特异性为69%,准确性为83%。结论:UKTP静脉溶栓治疗AMI血管开通疗效肯定,临床标准判断血管再通的敏感性较高,但特异性欠佳,有待提高。 | The multicentre investigating group of thrombolytic therapy on acute myocardial infarction with Urokinase Techpool Correspondence: Hu Dayi, Xu Zhimin. Chaoyang Red Cross Hospital, Capital University of Medical Sciences, Beijing 100020 | 1997 | 中华心血管病杂志1997，25，4： | 11 |
| 3 | 急性高血糖对ST段抬高性心肌梗死院内预后的影响显示文摘目的探讨急性高血糖对 ST 段抬高性心肌梗死(STEMI)患者院内预后的影响。方法连续入选356例北京地区17家三级和二级医院所有在24h 内入院且符合 STEMI 诊断标准的患者。以人院血糖水平>11mmol/L 判定为高血糖,分为高血糖组和血糖正常组,观察两组患者院内死亡和心血管病事件的发生情况。院内心血管事件定义为院内再发心肌梗死、新发生的心力衰竭、严重心律失常及卒中。结果 356例 STEMI 患者中,存在急性高血糖患者共81例(22.8%)。其院内病死率较无急性高血糖患者显著增加(13.6%比5.1%,P=0.009),院内心血管事件发生率亦显著增多(32.1%比20.4%,P=0.027)。logistic 回归分析示,入院急性高血糖(OR 1.615,95%CI 1.116~2.338,P=0.011)为 STEMI 患者院内不良预后的独立危险因素。结论 STEMI 急性高血糖患者院内死亡及发生院内心血管事件的危险性显著高于入院血糖正常者。入院高血糖为 STEMI 患者院内不良预后的独立危险因素。 | Registry of acute treatment in myocardial infarction investigators. | 2007 | 中华内科杂志2007，46，10： | 9 |
| 4 | Randomised trial of intravenous Streptokinase,oral aspirin,both,or,neithcr among 17,187 cases of suspected acute myocardial infarction: ISIS-2 显示文摘 | Collins R Yusuf S ISIS-2 ( Second International Study of Infarct Survival Collaborative Group ) | | Lancet0，，： | 2 |
| 5 | Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction显示文摘 | ISIS-2( Second Intemational Study of Infarct Survival)Collaborative Group | 1988 | lancet1988，345，8613： | 1 |
| 6 | A report of the American college of/American heart association task force on practice guidelines显示文摘 | ACC/HAH guidelines for the management of patiens with unstable angina and non- ST - segment elevation myocardial infarction | 2000 | JACC2000，36，： | 1 |
| 7 | Circulation显示文摘 | Hama N Rapid ventricular induction ofbrain natriuretic peptide geneexpression in experimental acute myocardial infarction | 1995 | 92(6): 1558- 15641995，92，6： | 1 |
| 8 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST - segment elevation 显示文摘 | Task Force on the management of ST - segment elevation acute myocardial infarction of the European Society of Cardiology ( ESC ) Steg PG James SK | 2012 | Eur Heart J2012，33，20： | 1 |
| 9 | A Report of American College of Cardiology/American Heart Association Task Force or Practice Guidelines显示文摘 | ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation mycardical infarction | 2000 | GACC2000，36，2： | 1 |
| 10 | A report American collage of cardiology/American heart association task force or practice guidelines显示文摘 | ACC/AHA·Guidelines for the management of patientswith unstable angina and non-st-segment elevation myocardial infarction | 2000 | J Am Coll Cardiol2000，，36： | 1 |
| 11 | Effect of a novel free radical scavenger,edaravone(MCl-186),on acute brain infarction, randomized, placebc - controlled, doubleblind study at mutticenters显示文摘 | Edaravone acute infarction study group | 2003 | Cerebrovasc Dis2003，15，3： | 1 |
| 12 | Myocardial infarction redefined a consensus docrument of The Joint European Society of Cardiology/American College of Cardioloty Committee for the redefinition of myocardial infarction 显示文摘 | The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction | 2000 | J Am Coil Cardiol2000，36，： | 1 |
| 13 | Effect of a novel free radical cavenger,Eedaravone(MCI-186),on acute brain infarction,andonized,placebo controlled,double blind study at multicenters显示文摘 | Edaravone acute infarction study group | 2003 | Cerebrobasc Dis2003，15，12： | 1 |
| 14 | Effect of aNovel Free Radical,Edaravone (MCI-186),on Acute Brain Infarction Randomized,Placebo-Controlled,Double-Blind Study at Multicenters the Edaravone显示文摘 | The Edaravoe Acute Brain Infarction Study Group | 2003 | Cerebralvasc Dis2003，15，3： | 1 |
| 15 | The SCATI (Studio sulla Calciparina nell'Angina e nella Trombosi Ventricolare nell'Infarto) Group显示文摘 | Randomised controlled trial of subcutaneous calcium- heparin in acute myocardial infarction | 1989 | Lancet1989，2，8656： | 1 |
| 16 | The GUSTO investigators显示文摘 | An international randomized trial comparing four thrombolytic strate gies for acute myocardial infarction | 1993 | N Engl JM ed1993，329，10： | 1 |
| 17 | Effect of a Novel Free Radical Scavenger, Edaravone (MCI- 186), on Acute Brain Infarction 显示文摘 | Edaravone Acute Brain Infarction Study Group | 2003 | Cerebrovasc Dis2003，15，3： | 1 |
| 18 | Meeting highlights显示文摘 | ISIS-4 fourth international study of infarct survival Ferguson Ⅱ | 2009 | Circulation2009，89，： | 1 |
| 19 | Effect of a novel free radical scavenger,edaravone (MCI-186),on acute brain infarction显示文摘 | Edaravone Acute Brain Infarction Study Group | 2003 | Cerebrovasc Dis2003，15，： | 1 |
| 20 | A report of American college of cardiology/American heart association task force or practice guidelines显示文摘 | ACC/AHA Guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction | 2000 | J Am Coll Cardiol2000，36，： | 1 |
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