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| 1 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 2 | Isolation and characterization of bipotent liver progenitor cells from adult mouse显示文摘 | Li WL Su J Yao YC Tao XR Yan YB Yu HY Wang XM Li JX Yang YJ Lau JT HuYP | 2006 | 中国生物学文摘2006，20，5： | 26 |
| 3 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 4 | Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘 | Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W | 2006 | 中国生物学文摘2006，20，8： | 23 |
| 5 | Cloning and expression of MXR7 gene in human HCC tissue显示文摘AIM To clone and identify the whole cDNA ofMXR7 gene and to find out its expression inhuman HCC,and normal tissues.METHODS The DNA primers were designed andsynthesized according to the whole cDNAsequence of MXR? gene.The cDNA of humanHCC was taken as the template while the cDNA ofMXR7 gene was synthesized by polymerasechain reaction(PCR).Recombinant DNAconforming to reading frame was constructed byconnecting purified PCR product of the cDNA ofMXR? gene with expression vector pGEX-5X-1 offusion protein.The plasmid MXRT/pGEX-5X-1was identified by sequencing.Using 32p labeledMXR? cDNA as probe,MXR7 mRNA expressionwas detected by Northern blot analysis in 12different human normal tissues,7 preoperativelyuntreated non-liver tumor tissues,30preoperatively untreated HCC,theparacancerous liver tissues and 12 normal livertissues samples.RESULTS Restriction enzyme and sequenceanalysis confirmed that the insertion sequence invector pGEX-5X-1 was the same as the cDNAsequence of MXR7 gene.Northern blot analysisshowed no expression of MXR? mRNA in 12 kindsof normal human tissues including liver,7 tumortissues in other sites and 12 normal livertissues,the frequencies of MXR7 mRNA expression in HCC and paracancerous livertissues were 76.6% and 13.3%,respectively.The frequency of MXR7 mRNA expression in HCCwithout elevation of serum AFP and in HCC<5cm was 90%(9/10)and 83.3%(5/6),respectively.CONCLUSION MXR7 mRNA is highly expressedin human HCC,which is specific and occurs at anearly stage of HCC,suggesting MXR7 mRNA canbe a tumor biomarker for HCC.The detection ofMXR7 mRNA expression in the biopsied livertissue is helpful in discovering early subclinicalliver cancer in those with negative serum AFP. | Zhou XP Wang HY Yang GS Chen ZJ Li BA Wu MC | 2000 | World Journal of Gastroenterology2000，6，1： | 23 |
| 6 | 基于Baveno Ⅵ标准和脾硬度在病毒学抑制的乙型肝炎肝硬化患者中排除高风险静脉曲张的研究显示文摘目前尚无数据可证实HBV相关肝硬化在病毒抑制的情况下,脾硬度在排除高风险静脉曲张方面的性能。因此,该研究旨在前瞻性地验证脾硬度(临界值46 kPa)结合Baveno VI标准在排除这些患者的高风险静脉曲张中的性能。 | WANG HY WEN B CHANG XY 王海玉 | 2021 | 临床肝胆病杂志2021，37，3： | 17 |
| 7 | Associating liver partition and portal vein ligation for staged hepatectomy: the current role and development显示文摘BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) has recently been developed to induce rapid liver hypertrophy and reduce posthepatectomy liver failure in patients with insufficient future liver remnant(FLR). ALPPS is still considered to be in an early developmental phase because surgical indications and techniques have not been standardized. This article aimed to review the current role and future developments of ALPPS.DATA SOURCES: Studies were identified by searching MEDLINE and Pub Med for articles from January 2007 to October 2016 using the keywords 'associating liver partition and portal vein ligation for staged hepatectomy' and 'ALPPS'. Additional papers were identified by a manual search of references from key articles.RESULTS: ALPPS induces more hypertrophy of the FLR in less time than portal vein embolization or portal vein ligation.The benefits of ALPPS include rapid hypertrophy 47%-110% of the liver over a median of 6-16.4 days, and 95%-100% completion rate of the second stage of ALPPS. The main criticisms of ALPPS are centered on its high morbidity and mortality rates. Morbidity rates after ALPPS have been reported to be 15.3%-100%, with ≥ the Clavien-Dindo grade III morbidity of 13.6%-44%. Mortality rates have been reported to be 0%-29%.The important questions to ask even if oncologic long-term results are acceptable are: whether the gain in quality and quantity of life can be off balance by the substantial risks of morbidity and mortality, and whether stimulation of rapid liver hypertrophy also accelerates rapid tumor progression and spread. Up till now, the documentations of the ALPPS procedure come mainly from case series, and most of these series include heterogeneous groups of malignancies. The numbers are also too small to separately evaluate survival for different tumor etiologies.CONCLUSIONS: Currently, knowledge on ALPPS is limited, and prospective randomized studies are lacking. From the reported preliminary results, safety of the ALPPS procedure remains questionable. ALPPS should only be used in experienced, high-volume hepatobiliary centers. | Wan Yee Lau Eric CH Lai Stephanie HY Lau | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 16 |
| 8 | 肌筋膜痛综合征基于脊髓节段性敏感的诊断和治疗(一)显示文摘 | Bryan O Young Hy Dubo Andrew A. Fischer 谢斌 王宁华 李建军 | 2009 | 中国康复理论与实践2009，15，6： | 15 |
| 9 | Leaf orientation, photorespiration and xanthophyll cycle protect young soybean leaves against high irradiance in field显示文摘 | Jiang, CD Gao, HY Zou, Q Jiang, GM Li, LH | 2006 | 中国生物学文摘2006，20，2： | 12 |
| 10 | Effects of continuous cucumber cropping and alternative rotations under protected cultivation on soil microbial community diversity显示文摘 | Yao HY Jiao XD Wu FZ | 2007 | 中国生物学文摘2007，21，8： | 10 |
| 11 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 12 | Economic burden of Parkinson's disease in a developing country: A retrospective cost analysis in Shanghai, China显示文摘 | Wang G Cheng Q Zheng R Tan YY Sun XK Zhou HY Ye XL Wang Y Wang Z Sun BM Chen SD | 2006 | 中国生物学文摘2006，20，8： | 10 |
| 13 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 14 | Little girl who conquered the 'ALPPS''显示文摘An insufficient future liver remnant(FLR)is associated with post-hepatectomy liver failure.Associating liver partition and portal vein ligation for stage hepatectomy(ALPPS)has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR.We hereby report our experience of this novel approach for a 6-year-old patient with hepatoblastoma.Computed tomography showed a hepatoblastoma measuring12.5 cm×9.9 cm×11.7 cm in the right liver(Couinaud segmentⅣ,ⅤandⅧ).Volumetric assessment of the FLR i.e.,left lateral section was 112.6 mL i.e.,21.2%of the estimated total liver volume.In view of the small-for-size FLR,ALPPS was contemplated.An anterior approach was adopted for the in-situ parenchymal split without mobilisation of the right liver.FLR volumetry on the seventh postoperative day was 160.7 mL,which represented a 46.1%gain in volume,and a FLR/ESLV ratio of 30.2%.A right trisectionectomy was performed on the eighth postoperative day.Postoperative recovery was uneventful.Patient was discharged on day 16 after the first operation.To our knowledge,this was the first report that showed the applicability of ALPPS to a paediatric patient. | Albert Chan Patrick HY Chung Ronnie TP Poon | 2014 | World Journal of Gastroenterology2014，20，29： | 8 |
| 15 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 16 | 肌筋膜痛综合征基于脊髓节段性敏感的诊断和治疗(二)显示文摘 | Bryan O Young Hy Dubo Andrew A.Fischer 谢斌 王宁华 李建军 | 2009 | 中国康复理论与实践2009，15，7： | 7 |
| 17 | Cloning and expression of NS3 cDNA fragment of HCV genome of Hebei isolate in E.coli显示文摘CloningandexpressionofNS3cDNAfragmentofHCVgenomeofHebeiisolateinE.coliZHUFenLu,LUHaoYing,LIZhuoandQIZhongTianSubjectheadin... | Zhu, FL Lu, HY Li, Z Qi, ZT | 1998 | World Journal of Gastroenterology1998，4，2： | 7 |
| 18 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 19 | Building an Earth Observations Data Cube: lessons learned from the Swiss Data Cube (SDC) on generating Analysis Ready Data (ARD)显示文摘Pressures on natural resources are increasing and a number of challenges need to be overcome to meet the needs of a growing population in a period of environmental variability.Some of these environmental issues can be monitored using remotely sensed Earth Observations(EO)data that are increasingly available from a number of freely and openly accessible repositories.However,the full information potential of EO data has not been yet realized.They remain still underutilized mainly because of their complexity,increasing volume,and the lack of efficient processing capabilities.EO Data Cubes(DC)are a new paradigm aiming to realize the full potential of EO data by lowering the barriers caused by these Big data challenges and providing access to large spatio-temporal data in an analysis ready form.Systematic and regular provision of Analysis Ready Data(ARD)will significantly reduce the burden on EO data users.Nevertheless,ARD are not commonly produced by data providers and therefore getting uniform and consistent ARD remains a challenging task.This paper presents an approach to enable rapid data access and pre-processing to generate ARD using interoperable services chains.The approach has been tested and validated generating Landsat ARD while building the Swiss Data Cube. | Gregory Giuliani Bruno Chatenoux Andrea De Bono Denisa Rodila Jean-Philippe Richard Karin Allenbach Hy Dao Pascal Peduzzi | 2017 | Big Earth Data2017，1，1： | 7 |
| 20 | 糖尿病前期与全因死亡和心血管疾病风险的相关性:更新的meta分析显示文摘目的评估在普通人群和有动脉粥样硬化性心血管疾病(ASCVD)病史的患者中,糖尿病前期与全因死亡率和心血管疾病风险的相关性。研究设计对前瞻性队列研究或临床试验的事后分析进行meta分析。数据来源截至2020年4月25日PubMed、EMBASE和Google Scholar等电子数据库。方法如果前瞻性队列研究或临床试验的事后分析报告了与正常血糖相比,糖尿病前期人群中校正后的全因死亡或心血管疾病(CVD)的相对风险比(RR)、优势比或风险比,该研究则纳入分析。数据由两名研究者独立提取。使用随机效应模型计算股和95%可信区间(CI)。主要结局是全因死亡率和复合心血管疾病,次要结局包括冠心病和卒中的发生风险。结果meta分析共纳入129项研究,包括10069955名参与者的数据进行分析。在普通人群中,中位随访时间9.8年,与正常血糖者相比,糖尿病前期人群的全因死亡(RR 1.13,95%CI 1.10-1.17)复合CVD(RR 1.15,95% CI1.11-1.18)、冠心病(RR 1.16,95%CI 1.11-1.21)和卒中(RR 1.14,95%CI 1.08-1.20)的风险均增加。与正常血糖者相比,糖尿病前期人群的全因死亡、复合CVD、冠心病(CHD)和卒中的绝对风险差异分别为9.59(95%CI 7.36~12.51),8.75(95%CI 6.41-10.49)、6.59(95%CI 4.53-8.65)和3.68(95%CI 2.10-5.26)每10000人年。与空腹血糖受损人群相比,糖耐量异常人群(IGT)具有较高的全因死亡、冠心病和卒中风险。在动脉粥样硬化性心血管疾病(ASCVD)的患者中,经过中位随访时间3.2年后,糖尿病前期人群的全因死亡(RR 1.36,95%CI 1.21-1.54)、复合CVD(RR 1.37,95%CI 1.23-1.53)、冠心病(RR 1.15,95%CI 1.02-1.29)的风险均较正常血糖人群显著增加,但卒中风险未见统计学差异(RR 1.05,95%CI 0.81-1.36)。与正常血糖相比,糖尿病前期中全因死亡、复合CVD、CHD和卒中的绝对风险差异为66.19(95%CI 38.60~99.25),189.77(95%CI 117.97~271.84),40.62(95%CI 5.42-78.53)和8.54(95%CI 32.43~61.45)每10000人年。在ASCVD患者中,所有观察的结局在不同定义下的糖尿病前期,风险均无显著异质性(所有P>0.10)。结论在普通人群和ASCVD人群中,糖尿病前期均与患者的全因死亡率和心血管疾病的风险增加相关。糖尿病前期的筛查和适当的管理可能有助于心血管疾病的一级和二级预防。 | 蔡晓燕 张云龙 李美君 Uason HY Wu 麦林琳 李军 杨宇 胡允兆 黄裕立 | 2021 | 英国医学杂志中文版2021，24，9： | 6 |
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