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| 1 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020，17，1： | 5 |
| 2 | Optimizing any-aged management of mixed boreal forest under residual basal area constraints显示文摘The current trend of forest management in many countries is reduced use of clear-felling and planting, and increased use of continuous cover management. In Finland, the new forest act of 2014 made all types of cuttings equally allowable on the condition that if the post-cutting residual stand basal area is too low, the stand must be regenerated within certain time frame. Forest landowner can freely choose between evenand uneven-aged management. This study developed a method for optimizing the timing and type of cuttings without the need to categorize the management system as either even-aged or uneven-aged. A management system that does not set any requirements on the sequence of post-cutting diameter distributions is called any-aged management. Planting or sowing was used when stand basal area fell below the required minimum basal area and the amount of advance regeneration was less than required in the regulations. When the cuttings of 200 stands managed earlier with even-aged silviculture were optimized with the developed system, final felling followed by artificial regeneration was selected for almost 50% of stands. Reduction of the minimum basal area limit greatly decreased the use of artificial regeneration but improved profitability, suggesting that the truly optimal management would be to use natural regeneration in financially mature stands. The optimal type of thinning was high thinning in 97–99 % of cases. It was calculated that the minimum basal area requirement reduced the mean net present value of the stands by 12–16 % when discount rate was 3–5 %. | Timo Pukkala Erkki L?hde Olavi Laiho | 2014 | Journal of Forestry Research2014，25，3： | 5 |
| 3 | Cadmium isotope fractionation reveals genetic variation in Cd uptake and translocation by Theobroma cacao and role of natural resistanceassociated macrophage protein 5 and heavy metal ATPase-family transporters显示文摘In response to new European Union regulations,studies are underway to mitigate accumulation of toxic cadmium(Cd)in cacao(Theobroma cacao,Tc).This study advances such research with Cd isotope analyses of 19 genetically diverse cacao clones and yeast transformed to express cacao natural resistance-associated macrophage protein(NRAMP5)and heavy metal ATPases(HMAs).The plants were enriched in light Cd isotopes relative to the hydroponic solution withΔ^(114/110)Cd_(tot-sol)=−0.22±0.08‰.Leaves show a systematic enrichment of isotopically heavy Cd relative to total plants,in accord with closed-system isotope fractionation ofΔ^(114/110)C_(dseq-mob)=−0.13‰,by sequestering isotopically light Cd in roots/stems and mobilisation of remaining Cd to leaves.The findings demonstrate that(i)transfer of Cd between roots and leaves is primarily unidirectional;(ii)different clones utilise similar pathways for Cd sequestration,which differ from those of other studied plants;(iii)clones differ in their efficiency of Cd sequestration.Transgenic yeast that expresses TcNRAMP5(T.cacao natural resistance-associated macrophage gene)had isotopically lighter Cd than did cacao.This suggests that NRAMP5 transporters constitute an important pathway for uptake of Cd by cacao.Cd isotope signatures of transgenic yeast expressing HMA-family proteins suggest that they may contribute to Cd sequestration.The data are the first to record isotope fractionation induced by transporter proteins in vivo. | Rebekah E.T.Moore Ihsan Ullah Vinicius Hde Oliveira Samantha J.Hammond Stanislav Strekopytov Mark Tibbett Jim M.Dunwell Mark Rehkämper | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | Hysteroscopy in menopause: analysis of the techniques and accuracy of the method 显示文摘 | Costa Hde L Costa LO | 2008 | Rev Bras Ginecol Obstet2008，30，10： | 1 |
| 5 | Crea- tion of a neovagina in patients with Rokitansky syndrome u- sing peritoneum from the pouch of Douglas:an analysis of 48 cases显示文摘 | Marques Hde S dos Santos FL Lopes-Costa PV | 2008 | Fertil Steril2008，90，3： | 1 |
| 6 | Growth and yield models for uneven-sized forest stands in Finland显示文摘 | Pukkala T L(a)hde E Laiho O | | 0，，： | 1 |
| 7 | Species interactions in the dynamics of evenand uneven-aged boreal forests显示文摘 | Pukkala T L(a)hde E Laiho O | | 0，，04： | 1 |
| 8 | Mild dystrophic damage in the androgen-sensitive levator ani muscle of the mdx omouse 显示文摘 | Souccar C Goncalo Mdo C Buck Hde S | 2005 | Neuromuscul Disord2005，15，1： | 1 |
| 9 | A modelling system for predicting urban air pollution: model description and applications in the Helsinki metropolitan area显示文摘 | A. Karppinen J. Kukkonen T. Elol?hde M. Konttinen T. Koskentalo E. Rantakrans | 2000 | Atmospheric Environment2000，，22： | 1 |
| 10 | Biofilm disclosing agents in complete denture:clinical and antimicrobial evaluation显示文摘 | Silva C H Paranhos Hde F Ito I Y | 2002 | Pesqui Odontol Bras2002，16，3： | 1 |
| 11 | Noise reduction in small- animal PET images using amultiresolution transform显示文摘 | MEJIA J M OCHOADOMINGUEZ HDE J VERGARAVILLEGAS O O | 2014 | IEEE Trans Med Imaging2014，33，10： | 1 |
| 12 | impulsfluorimetrie bei einzelzellen in suspensionen显示文摘 | Dittrich W G Hde W | 1969 | Z Naturf1969，24，： | 1 |
| 13 | Efficacy of biofilm disclosing agent and of three brushes in the control of complete denture cleansing显示文摘 | da Silva CH Paranhos Hde F | | 0，，06： | 1 |
| 14 | Silvicultural alternatives in an uneven-sized forest dominated by Picea abies显示文摘 | L(a)hde E Laiho O Lin J | | 0，，： | 1 |
| 15 | Pancreatic Duct Abnormalities and Pancreatic Function in Patients with Chronic Inflammatory Bowel Disease显示文摘 | B. Heikius S. Niemel? J. Lehtola T. Karttunen S. L?hde | 1996 | Scandinavian Journal of Gastroenterology1996，，5： | 1 |
| 16 | Creation of a neovagina in patients with Rokitansky syndrome using peritoneu from the pouch of Douglas: an analysis of 48 cases 显示文摘 | Marques Hde S dos Santos FL Lopes-Costa PV | 2008 | Fertil Steril2008，90，3： | 1 |
| 17 | Biofilm formation by staphylococcus haemolyticus显示文摘 | Elizabeth Gladys Aarag Fredheim Claus Klingenberg Holger Ro- hde | 2009 | J Clin Microbio12009，47，4： | 1 |
| 18 | Cutaneous Rosai -Dorfman disease显示文摘 | Indim F M Hios - Hde O Costa C 0 | 2009 | J An Bras 1 )ermatol2009，84，3： | 1 |
| 19 | Venous ulcer: clinical character- istics and risk factors显示文摘 | Abbade LP Last6ria S Rollo Hde A | 2011 | Int J Dermatol2011，50，4： | 1 |
| 20 | Mitechondrial p53 activates Bak and causes disruption of a Bak-Mell complex显示文摘 | LEU J I DUMONT P HDE Y M | 2004 | Nat Cell Biol2004，6，： | 1 |
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