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| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 3 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 4 | Optimization of biliary drainage in inoperable distal malignant strictures显示文摘BACKGROUND Given most patients with distal malignant biliary obstruction present in the nonresectable stage,palliative endoscopic biliary drainage with fully covered metal stent(FCMS)or uncovered metal stent(UCMS)is the only available measure to improve patients’quality of life.Half covered metal stent(HCMS)has been recently introduced commercially.The adverse effects and stent function between FCMS and UCMS have been extensively discussed.AIM To study the duration of stent patency of HCMS and compare it with FCMS and UCMS to optimize biliary drainage in inoperable patients with distal malignant obstruction.Secondary aims in our study included evaluation of patients’survival and the rates of adverse events for each type of stent.METHODS We studied 210 patients and randomized them into three equal groups;HCMS,FCMS and UCMS were inserted endoscopically.RESULTS Stent occlusion occurred in(18.6%,17.1%and 15.7%in HCMS,FCMS and UCMS groups,respectively,P=0.9).Stent migration occurred only in patients with FCMS(8.6%of patients).Cholangitis and cholecystitis occurred in 11.4%and 5.7%of patients,respectively,in FCMS.Tumor growth occurred only in 10 cases among patients with UCMS after a median of 140 d,sludge occurred in nine,seven and one patients in HCMS,FCMS and UCMS,respectively(P=0.04).CONCLUSION Given the prolonged stent functioning time,the use of HCMS is preferred over the use of UCMS and FCMS for optimizing biliary drainage in patients with distal malignant biliary obstruction. | Esam Elshimi Wesam Morad Omar Elshaarawy Ahmed Attia | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，9： | 5 |
| 5 | Wear and mechanical characterization of Mg-Gr self-lubricating composite fabricated by mechanical alloying显示文摘In this research,the wear and mechanical responses of pure magnesium-graphite(Mg-Gr)composite have been investigated aiming to get the optimum composition of reinforcement.The composite materials were fabricated by mechanical alloying.The percentage of graphite reinforcement was chosen as 3,5,7 and 10 wt.%to identify its potential for self-lubricating property under dry sliding conditions.The mechanical properties including hardness,tensile strength and flexural strength of the composites and the base material were tested.The wear tests were conducted by using a pin-on-disc tribometer.The results show that the mechanical properties decrease with increasing graphite content as compared to that of the base material.The wear rate and average coefficient of friction decrease with the addition of graphite and was found to be minimum at 5 wt.%graphite reinforcement.The addition of 5 wt.%graphite in the composite exhibits superior wear properties as compared to that of the matrix material and other compositions of the Mg-Gr composites. | Azzat Esam Abdulqader Al-maamari AKMAsif Iqbal Dewan Muhammad Nuruzzaman | 2019 | Journal of Magnesium and Alloys2019，7，2： | 2 |
| 6 | 中行湖北分行超高层办公楼结构设计显示文摘中行湖北分行办公楼建筑总高度为239.9m,采用钢管混凝土柱+钢梁混合框架+钢筋混凝土核心筒的混合结构体系,核心筒剪力墙为整体结构提供大部分的抗侧刚度,筒体与楼盖钢梁之间采用铰接,在15层、30层设置了伸臂桁架和带状桁架形成加强层。分析表明,结构体系能满足承载力、整体稳定性、抗侧力和变形的需求。结构多项指标超限,根据设定的抗震性能目标,针对不同重要性的构件采取不同的性能水准进行了分析和设计。通过罕遇地震作用下的弹塑性时程分析,找出了结构潜在的抗震薄弱部位和薄弱构件,并提出了相应的抗震加强措施。 | Esam Ali 乐胜辉 侯国求 卢亦焱 | 2018 | 建筑结构2018，48，21： | 2 |
| 7 | Illumination InvariantFeature Extraction and Mutual--Information-based LocalMatching for Face Recognition Under Illumination Variation andOcclusion显示文摘 | Nabatchian A Esam A R Ahmadi M | 2011 | Pattern Recognition2011，44，10： | 1 |
| 8 | Performance study on a structured packed liquid desiccant regenerator 显示文摘 | Esam Elsarrag | 2006 | Solar Energy2006，80，3： | 1 |
| 9 | The role of periodic vortex shedding in heat transfer enhancement for transient pulsatile flow inside wavy channels显示文摘 | ESAM M A RAED I B | 2008 | Proceedings of World Academy of Science Engineering & Technology2008，，22： | 1 |
| 10 | Effect of lead acetate toxicity on experimental male albino rat显示文摘Objective:To evaluate the effect of different doses of lead acetate(1/20,1/40 and 1/60 of LD_(50))on body weight gain,blood picture,plasma prolein profile and the function of liver,kidney and thyroid gland.Methods:Male albino rats were divided into four groups,the first group represented the health control animals,while the second,third and fourth groups were ingested orally with sub lethal doses of load acetate(1/20,1/40 and 1/60)of the oral LD_(50),respectively.One dose was ingested every two days during the experimental period(14 weeks)including the adaptation time.Blood was collected and used for all analysis.Results:The results showed that,the ingestion of Pb^(2+)induced significant stimulation in glutamic-pyruvic transaminase(ALT)and glutamic-oxalacetic transaminease(AST)activity.Also,total soluble protein and albumin contents of plasma were significantly decreased,while the content of globulin was changed by the Pb^(2+)treatments.The cholinesteiase activity was inhibited,but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated,while plasma glucose level was elevated as a result of lead acetate intoxication.In case of blood picture,Pb^(2+)ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat's blood and the plasma levels of T3,T4 and blood WBCs count were decreased.Conclusions:It can be concluded that lead acetate has harmful effect on experimental male albino rats.Therefore,the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk. | Nabil M Ibrahim Esam A Eweis Hossam S El-Beltagi Yasmin E Abdel-Mobdy | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 1 |
| 11 | Performance study on a structured packed liquid desiccant regenerator 显示文摘 | ESAM E | 2006 | Solar Energy2006，80，： | 1 |
| 12 | Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4^(+) T cell activation显示文摘Classical human leukocyte antigen(HLA)molecules of the major histocompatibility classⅡ(MHCⅡ)complex present peptides for the development,surveillance and activation of CD4^(+) T cells.The nonclassical MHCⅡ-like protein HLA-DM(DM)catalyzes the exchange and loading of peptides onto MHCⅡmolecules,thereby shaping MHCⅡimmunopeptidomes.Natural variations of DM in both chains of the protein(DMA and DMB)have been hypothesized to impact peptide presentation,but no evidence for altered function has been reported.Here we define the presence of DM allotypes in human populations covered by the 1000 Genomes Project and probe their activity.The functional properties of several allotypes are investigated and show strong enhancement of peptide-induced T cell activation for a particular combination of DMA and DMB.Biochemical evidence suggests a broader pH activity profile for the new variant relative to that of the most commonly expressed DM allotype.Immunopeptidome analysis indicates that the compartmental activity of the new DM heterodimer extends beyond the late endosome and suggests that the natural variation of DM has profound effects on adaptive immunity when antigens bypass the canonical processing pathway. | Miguel Álvaro-Benito Eliot Morrison Friederike Ebner Esam T.Abualrous Marie Urbicht Marek Wieczorek Christian Freund | 2020 | Cellular & Molecular Immunology2020，17，2： | 1 |
| 13 | PCM Thermal Control Unit for Portable Electronic Devices:Experimental and Numerical Studies显示文摘 | Alawadhi Esam M Amon Cristina H | 2003 | IEEE Transactions on Components and Packaging Technologies2003，26，1： | 1 |
| 14 | Surface and interfacial activities of hydrophobically modified poly(vinyl alcohol)(PVA)显示文摘 | Yahya Garba O Ali Asrof Hamad Esam Z | 1996 | Polymer1996，37，7： | 1 |
| 15 | Marine corrosion protective coatings of hexagonal boron nitride thin films on stainless steel 显示文摘 | Esam Husain Tharangattu N Narayanan Jose Jaime Taha - Tijerina | 2013 | ACS Applied Materials and Interfaces2013，10，5： | 1 |
| 16 | Evaluation of antioxidant activity of some plant extracts and their application to ground beef patties显示文摘 | Esam H Mansour Ali H Khalil | 2000 | Food Chemistry2000，，2： | 1 |
| 17 | Ethnobotanical magnitude towards sustainable utilization of wild foliage in Arabian Desert显示文摘 | Prakash C. Phondani Arvind Bhatt Esam Elsarrag Yousef A. Horr | 2015 | Journal of Traditional and Complementary Medicine2015，，： | 1 |
| 18 | Evaporation rate of a novel tilted solar liquid desiccant regeneration system 显示文摘 | Esam Elsarrag | 2008 | Solar Energy2008，82，： | 1 |
| 19 | Diamond semiconductor technology for RF device application 显示文摘 | Gurbuz Y Esame O Tekin I | 2005 | Solid-State Electronics2005，49，7： | 1 |
| 20 | A white spot disease - 1 ike syndrom e in the Pacific b lu e sh rimp( L itopenaeus sty lirostris)as a form of bacterial shelld isease显示文摘 | Rejan P R Ram esam y P | | 0，，： | 1 |
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