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| 1 | “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases显示文摘Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA of Aspergillus nidulans, which is crucial for the initiation of mitosis in that organism. All 11 human Neks have been functionally assigned to one of the three core functions established for this family in mammals:(1) centrioles/mitosis;(2) primary ciliary function/ciliopathies; and(3) DNA damage response(DDR). Recent findings, especially on Nek 1 and 8, showed however, that several Neks participate in parallel in at least two of these contexts: primary ciliary function and DDR. In the core section of this in-depth review, we report the current detailed functional knowledge on each of the 11 Neks. In the discussion, we return to the cross-connections among Neks and point out how our and other groups' functional and interactomics studies revealed that most Neks interact with protein partners associated with two if not all three of the functional contexts. We then raise the hypothesis that Neks may be the connecting regulatory elements that allow the cell to fine tune and synchronize the cellular events associated with these three core functions. The new and exciting findings on the Nek family open new perspectives and should allow the Neks to finally claim the attention they deserve in the field of kinases and cell cycle biology. | Gabriela Vaz Meirelles Arina Marina Perez Edmárcia Elisa de Souza Ferna Luisa Basei Priscila Ferreira Papa Talita Diniz Melo Hanchuk Vanessa Bomfim Cardoso Jrg Kobarg | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 2 | PCA-based 3D Shape Reconstruction of Human Foot Using Multiple Viewpoint Cameras显示文摘This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot.From a foot database,an initial 3D model of the foot represented by a cloud of points is built.The shape parameters,which can characterize more than 92% of a foot,are defined by using the principal component analysis method.Then,using 'active shape models',the initial 3D model is adapted to the real foot captured in multiple images by applying some constraints(edge points distance and color variance).We insist here on the experiment part where we demonstrate the efficiency of the proposed method on a plastic foot model,and also on real human feet with various shapes.We propose and compare different ways of texturing the foot which is needed for reconstruction.We present an experiment performed on the plastic foot model and on human feet and propose two different ways to improve the final 3D shape's accuracy according to the previous experiments results.The first improvement proposed is the densification of the cloud of points used to represent the initial model and the foot database.The second improvement concerns the projected patterns used to texture the foot.We conclude by showing the obtained results for a human foot with the average computed shape error being only 1.06 mm. | Edmée Amstutz Tomoaki Teshima Makoto Kimura Masaaki Mochimaru Hideo Saito | 2008 | International Journal of Automation and computing2008，5，3： | 2 |
| 3 | Induction and regulation of epithelial mesenchymal transitions 显示文摘 | Boyer B Vails AM Edme N | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 4 | Patients with exocrine insufficiency due to chronic pancreatitis are undertreated: A Dutch national survey显示文摘 | Edmée C.M. Sikkens Djuna L. Cahen Casper van Eijck Ernst J. Kuipers Marco J. Bruno | 2012 | Pancreatology2012，，1： | 1 |
| 5 | Cytokine concentrations in exhaled breath condensates in systemic sclerosis 显示文摘 | Edme JL Tellart AS Launay D | 2008 | Inflamm Res2008，57，4： | 1 |
| 6 | Determination of DNA content and genome size in sugarcane 显示文摘 | EDMe S J COMSTOCK J C MILLER J D | 2005 | Journal American Society Sugar Cane Technologists2005，25，： | 1 |
| 7 | Ras induces NBT-II epi- thelial cell scattering through the coordinate activities of Rac and MAPK pathways 显示文摘 | Edme N Downward J Thiery JP | 2002 | Cell Sci2002，115，2： | 1 |
| 8 | Induction and regulation of epithe- lial-mesenchymal transitions 显示文摘 | Boyer B Vall6s AM Edme N | 2000 | Bioehem Pharmacol2000，60，8： | 1 |
| 9 | Longitudinal follow up study of smoker'S lung with thin section CT incorre-lation with pulmonary function tests显示文摘 | Edme JL Boulenguez C | 2002 | Radiology2002，222，1： | 1 |
| 10 | Induction and regulation of epithelial-mesenchymal transitions显示文摘 | Boyer B Valles A M Edme N | 2000 | Biochem Pharrnacol2000，60，8： | 1 |
| 11 | Induction and regulation of epithelial mesenchyrnal transitions显示文摘 | Boyer B Valles A M Edme N | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 12 | Acaricidal activity of an oleoresinous extract from Copaifera reticulata (Leguminosae: Caesalpinioideae) against larvae of the southern cattle tick, Rhipicephalus ( Boophilus ) microplus (Acari: Ixodidae)显示文摘 | Fernando de Freitas Fernandes Edméia de Paula Souza Freitas | 2007 | Veterinary Parasitology2007，，1： | 1 |
| 13 | Induction and regulation of epithelial mesenchymal transitions 显示文摘 | Boyer B Vail S Edme N | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 14 | Circadian variation of diet-induced thermogenesis显示文摘 | ROMON M EDME J L BOULENGUEZ C | 1993 | The American Journal of Clinical Nutrition1993，57，4： | 1 |
| 15 | Induction and regulation of epithelial mesenchymal transitions 显示文摘 | Boyer B Valles AM Edme N | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 16 | Sniff nasal inspiratory pressure in the longitudinal assessment of young Duchenne muscular dystrophy children 显示文摘 | Neve V Cuisset JM Edme JL | 2013 | Eur Respir J2013，42，3： | 1 |
| 17 | Earlier decline in sniff nasal inspiratory pressure than peak expiratory flow in children with Duchenne muscular dystrophy 显示文摘 | Neve V Edme JL Matran R | 2014 | Eur Respir J2014，44，5： | 1 |
| 18 | Induction and regulation of epithe- lial mesenchymal transitions显示文摘 | Boyer B Vall S Edme N | 2000 | Biochem Pharecol2000，60，8： | 1 |
| 19 | Induction and regulation of epithelial-mesenchymal transitions 显示文摘 | Boyer B Valles AM Edme N | 2000 | Biochem Pharmaeol2000，60，8： | 1 |
| 20 | Problems with medicaine packages: experiences reported to a Dutch medicine reporting system显示文摘 | Erica CG van Geffen Edme Meuwese | 2010 | The Annals of Phamlacothempy2010，44，： | 1 |
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