|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 破裂动脉瘤-栓塞或夹闭疗效相当(英文)显示文摘In the May 2009 issue of The Lancet Neurology,the 5-year follow-up results of the International Subarachnoid Aneurysm Trial(ISAT) were published.The authors concluded that,although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe disability after 1 year has vanished(primary endpoint),coiling should still be favored over neurosurgical clipping because mortality rates significantly favored coiling.In this commentary,it is this particular conclusion that is challenged by combining data from previous ISAT publications with the current 5-year follow-up results.This modified intent-to-treat analysis clearly demonstrates that the significant advantage in terms of mortality in favor of the endovascularly treated patients is no longer present,with a hazard ratio of 0.80 in favor of endovascular treatment(95% confidence interval: 0.60-1.05;P =.10).Therefore,for everyday clinical practice and decision making,coiling and clipping are to be considered equivalent in the long term. | Bakker NA Metzemaekers JD Groen RJ Mooij JJ Van Dijk JM | 2010 | 中华神经外科疾病研究杂志2010，9，3： | 41 |
| 2 | TGF-β signaling in vascular biology and dysfunction显示文摘转变生长因素(TGF )- 尾家庭成员是多功能的 cytokines 在细胞上得到他们的效果包括 endothelial 和墙壁的细胞,经由特定的类型我和类型 II serine/threonine kinase 受体和细胞内部的 Smad 抄写因素。为表明小径部件的 TGF- 尾家庭的猛烈老鼠模型在合适的蛋黄囊 angiogenesis 揭示了他们的批评重要性。在人的基因研究在这些发信号的部件连接了变化到象世袭出血性的毛细管扩张,主要肺的高血压和 Marfan 症候群那样的特定的心血管的症候群。在这评论,我们在我们 TGF- 尾受体在脉管的生物学和疾病发信号的角色的理解的现在的最近的进展,并且讨论这怎么可以被申请治疗。 | Marie-Jose Goumans Zhen Liu Peter ten Dijke | 2009 | Cell Research2009，19，1： | 28 |
| 3 | TGF-β family co-receptor function and signaling显示文摘转变生长因素 --(TGF-) 家庭成员,它包括 TGF-s, activins 和骨头形态基因的蛋白质,是多种的 cytokines 得到细胞类型特定的效果在一高度在许多不同纸巾的上下文依赖者举止。经由 single-transmembrane 类型的这些分泌蛋白质 ligands 信号我和类型 II serine/threonine kinase 受体和细胞内部的 SMAD 抄写因素。在发信号的解除管制在疾病的一个宽广数组被含有,并且含有对复杂罚款在细胞的发信号的回答调节的需要。TGF- 家庭受体发信号紧张,持续时间,特性和差异被调整或调停的一重要出现机制通过房间表面合作受体。这里,我们提供为 TGF- 家庭成员被识别了的合作受体的概述。当一些看起来对 TGF- 家庭成员特定时,其它与另外的小径被分享并且为信号集成提供可能的方法。这评论集中于 TGF- 家庭合作受体的新奇功能,它继续发现。 | Joachim Nickel Peter ten Dijke Thomas D. Mueller | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 26 |
| 4 | 油藏岩石润湿性对气驱剩余油微观分布的影响机制显示文摘注气驱是目前油田进一步提高原油采收率的重要措施之一,油藏岩石润湿性对注气的效果有重要影响。基于三维孔隙级网络模型,运用孔隙级流动模拟方法,系统研究了6种不同润湿性油藏注气过程的油气水孔隙级分布和气驱效果。结果表明,水湿和MWS混合润湿(小孔隙为油湿)体系中的注气效果相对于另外4种润湿体系较差;这4种效果较好的润湿体系分别是油湿、中性润湿、MWL混合润湿(大孔隙为油湿)和部分润湿(其中30%孔隙水湿)体系。 | 杨永飞 姚军 M.I.J.van Dijke | 2010 | 石油学报2010，31，3： | 20 |
| 5 | 绩效工资的非线性影响效应及其结构优化——基于前景理论的视角显示文摘绩效工资在实践中表现出的不适和错位引发人们对传统理性分析范式的反思。文章将员工心理计量过程纳入研究视野,运用前景理论修正并推演出不同心理框架交织下绩效工资的作用机制,运用曲线拟合检验其非线性影响效应,并在此基础上对绩效工资的结构优化进行系统仿真。研究表明,绩效工资对防御型任务有正向影响,但受心理计量折扣的影响增量递减;对促进型任务有'S形'非线性影响,当比例控制在30%左右时有助于抑制对伦理动机和成就动机的挤出效应,提高激励效果。 | 马君 Van Dijk Dina | 2013 | 财经研究2013，39，4： | 15 |
| 6 | WONCA研究论文摘要汇编——COPD第1秒用力呼气末容积/用力肺活量固定值与参考值下限的关系:基于人群的加拿大COPD队列研究报告显示文摘目的呼吸量测定的方法可以导致COPD的误诊,甚至造成不当治疗。本研究比较两种标准的临床指标的相关性,即第1秒用力呼气末容积/用力肺活量(FEV1/FVC)的固定值及其参考值下限。方法分析基于人群的加拿大COPD队列研究的数据,分析测量气流受限的呼吸量测定标准与患者报告的不良后果的关系,包括呼吸道症状、残疾、健康状况、病情加重、心血管疾病。用敏感性分析探索年龄及气流受限严重程度对上述指标相关性的影响。结果对4 882例40岁以上患者的数据进行分析。FEV1/FVC固定值测定的气流受限发生率为17%,参考值下限为11%。由FEV1/FVC固定值测定的气流受限的患者发生不良后果的可能性增高不明显;由FEV1/FVC固定值联合参考值下限测定为气流受限且患者FEV1低于预测值80%与发生不良后果的可能性更大。结论研究结果表明,单独使用FEV1/FVC固定值可能导致COPD的误诊。由FEV1/FVC固定值和参考值下限得出的诊断与低FEV1、临床后果有着密切关系。指南应考虑两种呼吸量测量法的异常,从而减少COPD的过度诊断。 | van Dijk W Tan W Li P 本刊编辑部 | 2015 | 中国全科医学2015，18，8： | 10 |
| 7 | UBE20 negatively regulates TRAF6-mediated NF-kB activation by inhibiting TRAF6 polyubiquitination显示文摘 | Xiaofei Zhang Juan Zhang Long Zhang Hans van Dam Peter ten Dijke | 2013 | Cell Research2013，23，3： | 8 |
| 8 | Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer显示文摘Glycosylation is a common posttranslational modification on membrane-associated and secreted proteins that is of pivotal importance for regulating cell functions.Aberrant glycosylation can lead to uncontrolled cell proliferation,cell-matrix interactions,migration and differentiation,and has been shown to be involved in cancer and other diseases.The epithelial-to-mesenchymal transition is a key step in the metastatic process by which cancer cells gain the ability to invade tissues and extravasate into the bloodstream.This cellular transformation process,which is associated by morphological change,loss of epithelial traits and gain of mesenchymal markers,is triggered by the secreted cytokine transforming growth factor-β(TGF-β).TGF-βbioactivity is carefully regulated,and its effects on cells are mediated by its receptors on the cell surface.In this review,we first provide a brief overview of major types of glycans,namely,N-glycans,O-glycans,glycosphingolipids and glycosaminoglycans that are involved in cancer progression.Thereafter,we summarize studies on how the glycosylation of TGF-βsignaling components regulates TGF-βsecretion,bioavailability and TGF-βreceptor function.Then,we review glycosylation changes associated with TGF-β-induced epithelial-to-mesenchymal transition in cancer.Identifying and understanding the mechanisms by which glycosylation affects TGF-βsignaling and downstream biological responses will facilitate the identification of glycans as biomarkers and enable novel therapeutic approaches. | Jing Zhang Peter ten Dijke Manfred Wuhrer Tao Zhang | 2021 | Protein & Cell2021，12，2： | 4 |
| 9 | Targeting TGFβ signal transduction for cancer therapy显示文摘Transforming growth factor-β(TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis.Dysregulation of TGFβ family signaling can lead to a plethora of developmental disorders and diseases,including cancer,immune dysfunction,and fbrosis.In this review,we focus on TGFβ,a well-characterized family member that has a dichotomous role in cancer progression,acting in early stages as a tumor suppressor and in late stages as a tumor promoter.The functions of TGFβ are not limited to the regulation of proliferation,differentiation,apoptosis,epithelial-mesenchymal transition,and metastasis of cancer cells.Recent reports have related TGFβ to effects on cells that are present in the tumor microenvironment through the stimulation of extracellular matrix deposition,promotion of angiogenesis,and suppression of the ant-tumor immune reaction.The pro-oncogenic roles of TGFβ have attracted considerable attention because their intervention provides a therapeutic approach for cancer patients.However,the critical function of TGFβin maintaining tissue homeostasis makes targeting TGFβa challenge.Here,we review the pleiotropic functions of TGFβin cancer initiation and progression,summarize the recent clinical advancements regarding TGFβ signaling interventions for cancer treatment,and discuss the remaining challenges and opportunities related to targeting this pathway.We provide a perspective on synergistic therapies that combine anti-TGFβ therapy with cytotoxic chemotherapy,targeted therapy,radiotherapy,or immunotherapy. | Sijia Liu Jiang Ren Peter ten Dijke | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 4 |
| 10 | 论动物血液产品的安全性显示文摘喷雾干燥血浆蛋白粉和血球蛋白粉是两种来源于动物血液的优质动物蛋白质。本文通过分析生产工艺和研究欧盟对待血液产品的历史来说明动物血液制品的安全性主要受原料来源、加工工艺、管理水平3个方面影响。 | Albert van Dijk 周增太 | 2007 | 中国饲料2007，，8： | 4 |
| 11 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 12 | 《话语与语境:从社会认知入手》介绍显示文摘《话语与语境:从社会认知人手》(Discourse and Context:A Sociocognitive Approach)的作者是荷兰语言学家、话语分析家Teun A.van Dijk,由剑桥大学出版社2008年出版。全书除序言外共分五章。全书所使用的语料是英国议会下院2003年关于对伊战争的辩论,尤其关注时任英国首相布莱尔的讲话内容。这部关于语境的专著旨在从社会认知角度探讨社会认知在控制话语的产生与理解的过程中所起到的关键作用,并提出了“语境模型”(context models)的概念。下面介绍其主要内容。 | Teun A.van Dijk 王梅 | 2012 | 当代语言学2012，14，3： | 3 |
| 13 | Systematic review of cystic duct closure techniques in relation to prevention of bile duct leakage after laparoscopic cholecystectomy显示文摘AIM To study the effect of different techniques of cystic duct closure on bile leakage after laparoscopic cholecystectomy(LC) for biliary disease.METHODS A systematic search of MEDLINE, Cochrane and EMBASE was performed. Rate of cystic duct leakage(CDL) was the primary outcome. Risk of bias was evaluated. Odds ratios were analyzed for comparison of techniques and pooled event rates for non-comparative analyses. Pooled event rates were compared for each of included techniques.RESULTS Out of 1491 articles, 38 studies were included. A total of 47491 patients were included, of which 38683(81.5%)underwent cystic duct closure with non-locking(metal)clips. All studies were of low-moderate methodological quality. Only two studies reported separate data on uncomplicated and complicated gallbladder disease. For overall CDL, an odds ratio of 0.4(95%CI: 0.06-2.48)was found for harmonic energy vs clip closure and an odds ratio of 0.17(95%CI: 0.03-0.93) for locking vs non-locking clips. Pooled CDL rate was around 1% for harmonic energy and metal clips, and 0% for locking clips and ligatures. CONCLUSION Based on available evidence it is not possible to either recommend or discourage any of the techniques for cystic duct closure during LC with respects to CDL,although data point out a slight preference for locking clips and ligatures vs other techniques. No separate recommendation can be made for complicated gallbladder disease. | Aafke H van Dijk Stijn van Roessel Philip R de Reuver Djamila Boerma Marja A Boermeester Sandra C Donkervoort | 2018 | World Journal of Gastrointestinal Surgery2018，10，6： | 3 |
| 14 | 仔猪肠道健康同高采食量相联系显示文摘断奶后仔猪保持合适的采食量就很少发生肠道损伤. | Albert van Dijk 董亚维 | 2012 | 广东饲料2012，21，8： | 3 |
| 15 | 话语分析——一门新的交叉学科显示文摘历史背景
话语分析是一门既古老又年轻的学科。它的起源可以追溯到两千多年前对语言、演说和文学的研究。毫无疑问,这门学科的一个重要的历史来源是古典修辞学——优美的讲演艺术。在当时,语法学(grammatjca)——在历史上语言学的前身——和正确运用语言的准则密切相关,而它的姐妹学科修辞学(rhetorica)则涉及政治场合和法律场合公开演说的计划、组织特别的运用,以及表演等等的各种规则。 | Teun A.van Dijk 徐赳赳 | 1990 | 当代语言学1990，，2： | 3 |
| 16 | 社会认知、社会权势与社会话语显示文摘问题与目标本文要阐述的一个主要论点是,认知、权势和话语之间的联系应该以这三个概念的社会性来构建。从权势概念本质上具有的社会或政治属性来说,这一点显而易见。就请用和话语而言亦是如此。但是,对认知我们尚需一个更具社会性的研究方法。认知的过程与心理表象并不是个人“纯粹”的思维现象,它有其重要的社会特性。这一点却被认知心理学家所忽视。 | Teun A.van Dijk 施旭 | 1991 | 当代语言学1991，，3： | 3 |
| 17 | New insights into TGF-β–Smad signalling显示文摘 | Peter ten Dijke Caroline S Hill | 2004 | Trends in Biochemical Sciences2004，，5： | 3 |
| 18 | Inventory and action plan for PFOS and related substances in Suriname as basis for Stockholm Convention implementation显示文摘Within the framework of the Stockholm Convention implementation in Suriname,the first inventory of perfluorooctane sulfonic acid(PFOS)has been developed.The major stocks of PFOS are firefighting foams with minor stocks in pesticides(ant baits)and possibly carpets.The inventory of firefighting foams assessed the import,current stocks and major use sites and recent releases.Considerable amount of PFOS and potentially PFOS containing firefighting foams are stored at the military base,the oil company and small firefighting departments throughout the country.The total amount of stored PFAS firefighting foam in Suriname is estimated to be at least 275.6 tonnes,where the major stockpile of 206 tonnes is at the oil storage facilities.For some of these foams PFOS content is confirmed and for others it is not clear if the foam contains PFOS or other per-or polyfluorinated alkylated substances(PFAS).The upper estimate of PFOS content is 4133 kg in these foams.Additionally,PFOS or other PFAS has also been discovered in fire extinguishers in institutions.The total amount of PFOS related substance EtFOSA imported with the pesticide sulfluramid was 75 kg.The imports were banned in 2014 and is controlled.A considerable amount of synthetic carpets are in stores even produced before 2003 where main use of PFOS from 3 M took place possibly containing PFOS related substances.A compilation of potentially PFOS contaminated sites has been made.Potentially contaminated sites result from firefighting foam use,dumpsites and sulfluramid use.The airport where firefighting foam was applied is above a major drinking water reservoir,where an urgent assessment is needed.Due to the lack of analytical capacity for PFOS and precursors,drinking water,firefighting foam or impacted carpets,could not been analysed.An action plan for the control of PFOS and other PFAS has been developed considering the synergy of the Stockholm Convention and the Strategic Approach to International Chemicals Management(SAICM)addressing this emerging pollution issue for developing countries. | Victorine Pinas Carmen Van Dijk Roland Weber | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 19 | Time to wake-up: Sleep problems and daytime sleepiness in long-term stroke survivors显示文摘 | Annette Sterr Katherine Herron Derk-Jan Dijk Jason Ellis | 2008 | Brain Injury (-)2008，，7： | 2 |
| 20 | 康复医学靶向发展显示文摘根据卫生部政策,未来所有的三级医院及大部分二级医院必须具备独立的康复医学部.这是将康复学科建设纳入医院近期发展战略的充足理由。 | Hans van Dijk 高悦 | 2012 | 中国医院院长2012，，23： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员