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| 1 | Giant squamous cell carcinoma of the gallbladder: A case report显示文摘BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor. | Marcelo AF Ribeiro Junior Murillo de Lima Favaro Stephanie Santin Cintia Magalhaes Silva Ana Paula Marconi Iamarino | 2019 | World Journal of Clinical Cases2019，7，18： | 2 |
| 2 | Influence of light source and extended time of curing on microhardness and degree of conversion of different regions of a nanofilled composite resin 显示文摘 | Lima AF de Andrade KM da Cruz Alves LE | 2012 | Eur J Dent2012，6，2： | 1 |
| 3 | Increased renal sympathetic nerve activity leads to hyperten sion and renal dysfunction in offspring from diabetic mothers显示文摘 | De Almeida Chaves Rodrigues AF de Lima IL Bergamaschi CT | 2013 | Am J Physiol Renal Physiol2013，304，2： | 1 |
| 4 | Increased renal sympathetic nerve activity leads to hyper- tension and renal dysfunction in offspring from diabetic mothers 显示文摘 | de Almeida Chaves Rodrigues AF de Lima IL Bergamaschi CT | 2013 | Am J Physioi Renal Physiol2013，304，2： | 1 |
| 5 | Anemia in chronic renal disease:evaluation of inflammatory activity on erythropoiesis and iron me tabolism in patients not submitted to dialysis treatment显示文摘 | De Lima GA Mazzali M Gentil AF | 2012 | Clin Lab2012，58，78： | 1 |
| 6 | Root coverage:comparison of coronally positioned flap with and without titanium-reinforced barrier membrane显示文摘 | Lins LH de Lima AF Sallum AW | 2003 | J Periodontol2003，74，2： | 1 |
| 7 | Clinical and radiographic treatment evaluation of class Ⅲ furcation defects using GTR with and without inorganic bone matrix显示文摘 | Palioto DB Joly JC de Lima AF | 2003 | J Clin Periodontol2003，30，1： | 1 |
| 8 | Clinical and radiographic evalu- ation of soft and hard tissue changes around implants : a pilot study 显示文摘 | Joly JC de Lima AF da Silva RC | 2003 | J Periodonto12003，74，8： | 1 |
| 9 | Anemia in chronic renal disease : evaluation of inflammatory activity on erythropoiesis and iron metabolism in patients not submitted to dialysis treatment显示文摘 | De Lima GA Mazzali M Gentil AF | 2012 | Clin Lab2012，58，78： | 1 |
| 10 | Anemia in chronic renal disease: evaluation of inflammatory activity on erythropoiesis and iron metabolism in patients not submitted to dialysis treatment显示文摘 | DE LIMA GA MAZZALI M GENTIL AF | 2012 | Clin Lab2012，58，78： | 1 |
| 11 | Clinical and radiographic treatment evaluation of class lIl furcation defects using GTR with and without inorganic bone matrix 显示文摘 | Palioto DB Joly JC de Lima AF | 2003 | Clin Periodontol2003，30，1： | 1 |
| 12 | Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis显示文摘 | Martorelli de Lima AF Cury CC Palioto DB | 2004 | J Clin Periodontol2004，31，8： | 1 |
| 13 | Epidemiologic profile of salivary gland neoplasms: Analysis of 245 cases显示文摘 | Lima SS Soares AF de Amorim RF | 2005 | Braz J Otorhinolaryngol2005，71，3： | 1 |
| 14 | Effect of surface treatments and bonding agents on the bond strength of repaired composites 显示文摘 | Cavaleant AN De Lima AF Peris AR | 2007 | J Esthet Restor Dent2007，，： | 1 |
| 15 | Anemia in chronic renal disease:evaluation of inflammatory act!vity on erythro- poiesis and Iron metabolism in patients not submitted to dial- ysis treatment 显示文摘 | De Lima GA Mazzali M Gentil AF | 2012 | Clin Lab2012，58，78： | 1 |
| 16 | Subsyndromal depression: an impact on quality of life?显示文摘 | da Silva Lima AF de Almeida Fleck MP | 2007 | J Affect Disord2007，100，123： | 1 |
| 17 | Increased creatine kinase and spontaneous activity on electromyography,in amyotrophic lateral sclerosis显示文摘 | Lima AF Evangelista T de Carvalho M | | 0，，： | 1 |
| 18 | Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats显示文摘瞄准:在一个动物模型在不含酒精的脂肝疾病(NAFLD ) 的预防每氧化和口头的 SNAC 管理的效果在类脂化合物的抑制评估 S-nitroso-N-acetylcysteine (SNAC ) 的潜力。方法:NAFLD 被胆碱缺乏的饮食为 4 wk 在 Wistar 雄的老鼠导致。对待 SNAC 的动物(n=6 )(1.4 mg/kg 每 SNAC 的天,口头上地) 与 2 个控制组相比:(n=6 ) 收到了 PBS 答案,其它(n=6 ) 收到了 NAC 答案(7 mg/kg 每天) 。组织学的变量半关于宏和 microvacuolar 脂肪被测定变化,它的带的分发,坏死的 foci,门和 perivenular 纤维变性,并且煽动性与带的分发渗入。从肝 homogenates 的样品的 LOOH 被 HPLC 确定。在门静脉的血浆的硝酸盐层次被化合光估计。水的低密度的脂蛋白(LDL ) 暂停(200 microg protein/mL ) 在 37 度摄氏为 15 h 在 SNAC (300 micromol/L ) 的缺席和存在与 CuCl (2 )(300 micromol/L ) 被孵化。LDL 氧化的程度被 fluorimetry 估计。亚油酸(LA )(18.8 micromol/L ) 氧化被大豆 lipoxygenase (SLO )(0.056 micromol/L ) 当面在 37 度摄氏导致并且 N-acetylcysteine (NAC ) 和 SNAC (56 和 560 micromol/L ) 的缺席并且在 234 点监视了 nm。结果:在控制组的动物在仙子门区域开发了中等的宏和微小囊的丰满的变化。对待 SNAC 的动物与丰满的变化的缺席显示了仅仅分离的组织学的改变并且没得肝脂肪变性。在对待 SNAC 的组的 NAFLD 的缺席断然在肝匀浆在 LOOH 的集中与减少被相关,与控制组相比(0.7+/-0.2 nmol/mg 对 3.2+/-0.4 nmol/mg 蛋白质,分别地 P<0.05 ) ,当 aminotransferases 的浆液层次是未改变的时。在每氧化阻止类脂化合物的 SNAC 的能力作为模型底层用 LA 和 LDL 在在试管内实验被证实。结论:SNAC 的口服在用胆碱缺乏的饮食喂的 Wistar 老鼠阻止 NAFLD 的发作。这效果与 SNAC 的能力被相关每氧化在试管内和在试管内堵住类脂化合物的繁殖。 | Claudia PMS de Oliveira Fernanda I Simplicio Vicencia MR de Lima Katia Yuahasi Fabio P Lopasso Venancio AF Alves Dulcinéia SP Abdalla Flair J Carrilho Francisco RM Laurindo Marcelo G de Oliveira | 2006 | World Journal of Gastroenterology2006，12，12： | 1 |
| 19 | Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases 显示文摘 | Lima SS Soares AF de Amorim RF | 2005 | Bras J Otorhinolaryngol2005，71，3： | 1 |
| 20 | Anemia in chronic renal dis-ease:evaluation of inflammatory activity on erythropoiesis and iron me-tabolism in patients not submitted to dialysis treatment显示文摘 | De Lima GA Mazzali M Gentil AF | 2012 | Clin Lab2012，58，78： | 1 |
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