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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 3 | Stress-induced 5-HT1A receptor desensitization: protective effects of Ginkgo biloba extract (EGb 761)显示文摘 | Bolanos-Jimenez F Manhaes de Castro R Sarhan H | 1995 | Fundam Clin Pharmacol1995，9，2： | 1 |
| 4 | The Construction of a Boolean Competitive Neural Network Using Ideas from Immunology显示文摘 | Von Zuben F J De Deus J G A | 2003 | Neurocomputing2003，50，： | 1 |
| 5 | Pneumococcal antimicro-bial resistance:therapeutic strategy and management in community-acquired pneumonia显示文摘 | Aspa J Rajas O de Castro F R | 2008 | Expert Opin Pharmacother2008，9，2： | 1 |
| 6 | Ultrasound-assisted levitation: Lab-on-a-drop 显示文摘 | Capote F Priego Luque de Castro | 2006 | Trends in Analytical Chemistry2006，25，9： | 1 |
| 7 | Immune and neural network models: theoretical and empirical comparisons 显示文摘 | de CASTRO L N van ZUBEN F J | 2001 | International Journal of Computational Intelligence and Applications2001，1，3： | 1 |
| 8 | Sequential(step-by-step) detection,identification and quantization of extra virgin olive oil adulteration by chemo metric treatment of chromatographic profiles显示文摘 | CAPOTE F P JIMINEZ J R LUQUE de CASTRO M D | 2007 | Analytical and Bioanalytical Chemistry2007，338，8： | 1 |
| 9 | Learning and Optimization Using the Clonal Selection Principle显示文摘 | De Castro L N Von Zuben F J | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 10 | Learning and optimization using the clonal selection principle 显示文摘 | DE CASTRO L N VON ZUBEN F J | 2002 | IEEE Trans Evolutionary Computation Special Issue on Artificial Immune Systems2002，6，3： | 1 |
| 11 | Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone显示文摘 | de Castro F Ruiz R Montoro L | 2003 | Fertil Steril2003，80，3： | 1 |
| 12 | Learning and Optimization Usingthe Clonal Selection Principle显示文摘 | De Castro L N Von Zuben F J | 2000 | IEEE Transactions on Evolu-tionary Computation2000，6，3： | 1 |
| 13 | Blends of cross- linked high amylose starch/pectin loaded with diclofenac显示文摘 | Soares G A de Castro A D Cury B S F | 2013 | Car- bohydrate Polymers2013，91，1： | 1 |
| 14 | Kinetic studies of lipase from Candida rugosa显示文摘 | Pereira E B DE Castro H F DE Moraes F F | 2001 | Appl Biochem Biotechnol2001，9193，： | 1 |
| 15 | Learning and optimization using the clonal selection principle显示文摘 | De CASTRO L N Von ZUBEN F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 16 | Pro- posing new variables for the identification of strategic groups in franchising 显示文摘 | Rondan Cataluna F J Garcia A N Diez de Castro E C | 2007 | International Entrepreneurship and Man- agement Journal2007，3，4： | 1 |
| 17 | Learning and optimization using the clonal selection principle显示文摘 | De Castro L N Von Zuben F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 18 | Learning and Optimization Using the Clone Selection Prineiple显示文摘 | de Castro L N von Zuben F J | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 19 | Emergence, longevity and fecundity of Trissolcus basalis and Telenomus podisi atter cold storage in the pupal stage显示文摘 | Foerster L A Doetzer A K de Castro L C F | 2004 | Pesquisa Agropecuaxia Brasileira2004，39，9： | 1 |
| 20 | Fertility of lactating dairy cows administered recombinant bovine somatotropin during heat stress 显示文摘 | F D Jousan L A de Castro e Paula J Block | 2007 | J Dairy Sci2007，90，1： | 1 |
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