|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 2 | A potential immune escape mechanism by melanoma ceils through the activation of chemokine-induced T cell death 显示文摘 | Mellado M de Ana AM Moreno MC | 2001 | Current Biology2001，11，9： | 1 |
| 3 | A potential immune escapc mechnism by melanoma cells through the activation of chemokine - induced T cell death 显示文摘 | Mellado M de Ana AM Moreno MC | 2001 | Curr Biol2001，11，9： | 1 |
| 4 | A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death显示文摘 | Mellado M de Ana AM Moreno MC | 2001 | Curr Biol2001，11，9： | 1 |
| 5 | Formation of DNA Strand Breaks in Peripheral Lymphocytes of Rats After Exposure to Natural Sunlight显示文摘Objective This paper aims to evaluate the genotoxicity in peripheral blood lymphocytes of rats after exposure to sunlight at different time points of day in a tropical region of Brazil(5oS,42oW).Materials and Methods Thirty Wistar-Hannover rats,three months old,were randomly divided into three groups of 10 animals each:Group I [control,without exposure to ultraviolet(UV) radiation],Group II(exposed to sunlight during 08:00 a.m.to 10:00 a.m.),and Group III(exposed to sunlight during 10:00 a.m.to 12:00 a.m.).After a week of exposure,peripheral blood samples were taken from the tail of these animals to prepare smears on two slides per animal.In 24 h after exposure to sunlight in Group III,a new collection was obtained to observe the repair activity.The alkaline comet assay was used in this study to evaluate the genotoxic activity of sunlight(P<0.05).Results There was no statistical difference between Group I and II(P=0.672).On the other hand,the exposure to sunlight in Group III showed genotoxic action in comparison to the other groups(P<0.0001).Also,there was no significant repair in Group III R(P=0.407).Conclusion This study has shown a genotoxic potential of sunlight(UVA-B) in lymphocytes of mammals from 10:00 a.m.to 12:00 a.m.,due to a higher intensity of UV in this tropical region. | Dorival Mendes RODRIGUES-JUNIOR Ana Amélia de CARVALHO MELO Benedito Borges da SILVA Pedro Vitor LOPES-COSTA | 2012 | Biomedical and Environmental Sciences2012，25，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员