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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | 循证指南更新:成人发作性偏头痛预防的药物治疗显示文摘目的提供偏头痛预防治疗的指南更新推荐,所提出的临床问题是什么样的药物治疗可有效预防偏头痛发作?方法作者对1999年6月—2009年5月间发表的研究使用结构式的评价程序来分类不同(美国可获得)药物对偏头痛预防的效果。结果和推荐作者评价了284篇摘要,最后对29篇包含Ⅰ类或Ⅱ类证据的文章进行综述。双丙戊酸、丙戊酸钠、托吡酯、美托洛尔、普萘洛尔和噻吗洛尔能有效预防偏头痛,应该用于偏头痛患者以减少发作频率及程度(A级证据)。夫罗曲坦可有效预防月经性偏头痛(A级证据)。拉莫三嗪对偏头痛预防无效(A级证据)。 | 邹静 李颖 冯智英 李焰生 Silberstein SD Holland S Freitag F Dodick DW Argoff C Ashman E | 2012 | 神经病学与神经康复学杂志2012，9，2： | 38 |
| 3 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 4 | 循证指南更新:非甾体类抗炎药和其他辅助治疗预防成人发作性偏头痛显示文摘目的为偏头痛预防性治疗提供最新循证推荐。所提出的临床问题是非甾体类抗炎药(NSAIDs)或其他辅助治疗是否对偏头痛预防有效?方法作者对1999年6月—2009年5月间发表的研究使用结构式的评价程序来分类不同药物对偏头痛预防的效果。结果作者总共回顾了284篇摘要,包括49篇偏头痛预防治疗的Ⅰ级或Ⅱ级证据,其中15篇为涉及非传统治疗、NSAIDs及其他辅助治疗的研究,予以了评价。推荐蜂斗菜对偏头痛预防治疗有效,应被用于偏头痛患者以降低偏头痛发作频率及严重程度(A级推荐)。非诺洛芬、布洛芬、酮洛芬、萘普生、萘普生钠、雏菊、镁剂、核黄素及组胺皮下注射对偏头痛预防很可能有效(B级推荐)。认为可能有效的药物包括赛庚啶、辅酶Q10、雌激素、甲芬那酸及氟比洛芬(C级推荐)。矛盾不一致或不足以支持或反对使用的药物包括阿司匹林、吲哚美辛、ω-3及高压氧。孟鲁司特对偏头痛预防治疗很可能无效(B级证据)。 | 华驾略 蒋仙国 季伟华 李焰生 Holland S Silberstein SD Freitag F Dodick DW Argoff C Ashman E | 2012 | 神经病学与神经康复学杂志2012，9，2： | 17 |
| 5 | 围手术期应用生长激素对肠外营养病人肠粘膜通透性、细胞免疫功能及预后的影响显示文摘目的 观察围手术期应用重组人生长激素 (rHGH)对肠外营养病人肠粘膜通透性、小肠粘膜形态、细胞免疫功能和预后的影响。 方法 前瞻性、随机、双盲、安慰剂对照的临床研究。 2 0例因胃肠道疾病行手术治疗的病人进入本研究。术前 3天至术后第 7天 ,研究组病人接受rHGH(0 .3IU·kg-1·d-1,皮下注射 )治疗 ,对照组接受安慰剂。从术前 1天至术后第 6天 ,两组病人接受等氮等热卡的肠外营养 (2 0Kcal·kg-1·d-1,N 0 .15 g·kg-1·d-1)。观察指标包括 :肠粘膜通透性、小肠粘膜形态、外周血淋巴细胞亚群和预后。 结果 (1)rHGH治疗显著提高了研究组病人血浆GH和IGF 1浓度 (P =0 .0 0 93~ 0 .0 2 9) ,而对照组血浆GH和IGF 1浓度较术前无变化 (P =0 .2 5~ 0 .6 9)。(2 )手术后对照组肠粘膜通透性较术前明显升高 (P =0 .0 1) ,研究组升高不明显 (P =0 .0 8)。研究组小肠粘膜厚度和绒毛高度与对照组比较无显著差别 (P =0 .5 4,P =0 .6 6 )。 (3)对照组病人术后CD4+淋巴细胞比例及CD4+/CD8+淋巴细胞比值较术前下降 (P =0 .0 3) ,研究组术后无明显变化 (P =0 .0 9~ 0 .49) ,两组间变化差值比较有显著性差异 (P =0 .0 2 )。 (4)临床未见与rHGH治疗有关的严重不反应。rHGH治疗后研究组空腹血糖较治疗前有升高趋? | 刘卫 蒋朱明 王秀荣 舒红 崔巍 Wilmore DW | 2001 | 中国临床营养杂志2001，9，2： | 9 |
| 6 | 牛津单髁膝关节置换:长期结果(英文)显示文摘牛津膝置换是使用最广泛的膝关节单髁置换(UKR)。牛津膝在37年前开始应用,拥有一个全匹配的活动衬垫,因而磨损率非常低。牛津膝最主要的使用指征是膝关节前内侧骨关节炎,这种病人至少占所有需要行膝关节置换术患者的50%。由于这一系统的设计特点,传统UKR的反指征,如年龄、活动量、肥胖、髌股关节损害和软骨钙质沉着症等对于牛津膝均不是反指征。与全膝关节置换(TKR)相比,牛津膝提供更快的康复、更好的功能、更大的活动度和更好的术后满意度,发生并发症更少、程度更轻,病残率和死亡率更低。一个持续超过30年的研究显示在90%的病例中,牛津膝为患者终生提供了优或良的临床结果,且不需要翻修。在最近15年,牛津膝通过微创手术入路植入,涉及6000多例使用该入路牛津膝置换的9个研究报道显示,10年生存率约95%。在许多这样的研究中,医生们在拟行膝关节置换的患者中约50%使用了牛津单髁膝置换。 | DW Murray BE Marks L Kontochristos CAF Dodd HG Pandit | 2013 | 中华关节外科杂志(电子版)2013，7，4： | 9 |
| 7 | Intraductalpapillarymucinousneoplasmofthebileductwithgastricand duodenalfistulas显示文摘Intraductal papillary mucinous neoplasm (IPMN) of the bile duct is still rare and not yet understood despite of its increased incidence and similar clinicopathologic characteristics compared with IPMN of the pancreas. The fistula formation into other organs can occur in IPMN, especially the pancreatic type. To our knowl-edge, only two cases of IPMN of the bile duct with a choledochoduodenal fistula were reported and we have recently experienced a case of IPMN of the bile duct penetrating into two neighboring organs of the stom-ach and duodenum presenting with abdominal pain and jaundice. Endoscopy showed thick mucin extruding from two openings of the fistulas. Endoscopic suction of thick mucin using direct peroral cholangioscopy with ultra-slim endoscope through choledochoduodenal fis-tula was very difficult and ineffective because of very thick mucin and next endoscopic suction through the stent after prior insertion of biliary metal stent into cho-ledochogastric fistula also failed. Pathologic specimen obtained from the proximal portion of the choledocho-gastric fistula near left intrahepatic bile duct through the metal stent showed a low grade adenoma. The pa-tient declined the surgical treatment due to her old age and her abdominal pain with jaundice was improved af-ter percutaneous transhepatic biliary drainage with the irrigation of N-acetylcysteine three times daily for 10 d. | Hong MY Yu DW Hong SG | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 8 | 成人急性髓系白血病治疗指南显示文摘 | Milligan DW Grimwade D CullisJ O 侯理 | 2006 | 国际输血及血液学杂志2006，29，2： | 7 |
| 9 | 实验关节软骨生物力学性质随深度变化显示文摘目的:探讨实验兔膝关节软骨生物力学性质是否随深度变化。方法:应用微应力实验装置分别测定不同层厚兔膝关节软骨的生物力学性质:整体模数(aggregatemodulus,HA)、普爱松模数(Poissonsratio,υs)、剪切弹性模量(shearmodulus,μ)及通透性(permeability,K)的变化。结果:表层软骨HA、μ明显低于深层软骨(P<0.05);而软骨的通透性从表层往深部逐渐增高(P<0.05)。结论:关节软骨的生物力学性质随深度变化。表层关节软骨对维持软骨生物力学性质是极其重要的,任何该区域性质的变化将明显地影响软骨的生物力学性质乃至正常的关节功能。 | 林建华 Shin,DW | 1998 | 中华骨科杂志1998，18，8： | 6 |
| 10 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 11 | 腔内修复破裂的腹主动脉瘤手术死亡率:一个系统评价和Meta分析显示文摘尽管现代外科取得了一些进展,但通过开放手术治疗破裂的腹主动脉瘤(ruptured abdominalaortic aneurysms,RAAAs)其死亡率仍高达50%左右。由于来到医院的患者存活率不到一半,由RAAAs所导致的死亡率更高,为80%-90%。最近,一个Meta分析对近50年的RAAAs修复进行了总结, | Karkos CD Harkin DW Giannakou A 刘军麟 殷梅 | 2010 | 中华普通外科学文献(电子版)2010，4，2： | 5 |
| 12 | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis显示文摘 | Nicholson DW Ali A Thornberry NA | | 0，，： | 4 |
| 13 | High-level expression of human calmodulin in E.coli and its effects on cell proliferation显示文摘INTRODUCTIONCalmodulin(CaM),widely distributed in almost alleukaryotic cells,is a major intracellular calcium receptorresponsible for mediating the Ca2+ signal to a multitude ofdifferent enzyme systems and is thought to play a vital rolein the regulation of cell proliferative cycle.Recently, | Li XJ Wu JG Si JL Guo DW Xu JP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 14 | 高分辨力CT在间质性肺疾病诊断中的作用显示文摘重点论述高分辨力 CT 在诊断弥漫性肺疾病尤其是轻微病变中的价值,指出高分辨力 CT 对弥漫性肺疾病的特异性诊断优于胸片及其它影象学技术。 | Hansell DW Kerr IH 尉迟以浩 王彤 | 1992 | 国外医学(呼吸系统分册)1992，12，1： | 3 |
| 15 | Caspases:killer proteases显示文摘 | Nicholson DW Thomberry NA | | 0，，： | 3 |
| 16 | Genome-level analysis of genetic regulation of liver gene expression networks显示文摘 | Gatti, D Maki, A Chesler, EJ Kirova, R Kosyk, O Lu, L Williams, RW Perkins, A Langston, MA Threadgill, DW Rusyn, I | 2007 | 中国生物学文摘2007，21，11： | 3 |
| 17 | Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130).显示文摘 | Beebe DW Ris MD Armstrong FD Fontanesi J Mulhern R Holmes E Wisoff JH | 2005 | 中国神经肿瘤杂志2005，3，3： | 3 |
| 18 | 中国与澳大利亚胃溃疡的比较研究显示文摘 | 李增烈 Piper,DW | 1993 | 中华消化杂志1993，13，1： | 3 |
| 19 | Direct isolation of human central nervous system stem cells显示文摘 | Uchida N Buck DW He D | | 0，，： | 2 |
| 20 | Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis显示文摘 | Herbrecht R Denning DW Patterson TF | | 0，，： | 2 |
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