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1Effects of resveratrol and other polyphenols in hepatic steatosis显示文摘Non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic steatohepatitis.Polyphenols are members of a very large family of plant-derived compounds that can have beneficial effects on human health,and thus their study has become an increasingly important area of human nutrition research.The aim of the present review is to compile published data concerning the effects of both isolated polyphenols as well as polyphenol extracts,on hepatocyte and liver fat accumulation under different steatosis-inducing conditions.The results reported clearly show that this group of biomolecules is able to reduce fat accumulation,but further studies are needed to establish the optimal dose and treatment period length.With regard to the potential mechanisms of action,there is a good consensus.The anti-lipidogenic effect of polyphenols is mainly due to reduced fatty acid and triacylglycerol synthesis,increased in fatty acid oxidation,and reduced of oxidative stress and inflammation.As a general conclusion,it can be stated that polyphenols are biomolecules which produce hepatoprotective effects.To date,these beneficial effects have been demonstrated in cultured cells and animal models.Thus,studies performed in humans are needed before these molecules can be considered as truly useful tools in the prevention of liver steatosis.Leixuri Aguirre Maria Puy Portillo Elizabeth Hijona Luis Buja 2014World Journal of Gastroenterology2014,20,23:11
2Smart Transformer-based Medium Voltage Grid Support by Means of Active Power Control显示文摘In the last decades the voltage regulation has been challenged by the increase of power variability in the electric grid,due to the spread of non-dispatchable generation sources.This paper introduces a Smart Transformer(ST)-based Medium Voltage(MV)grid support by means of active power control in the ST-fed Low Voltage(LV)grid.The aim of the proposed strategy is to improve the voltage profile in MV grids before the operation of On-Load Tap Changer in the primary substation transformer,which needs tens of seconds.This is realized through reactive power injection by the AC/DC MV converter and simultaneous decrease of the active power consumption of voltage-dependent loads in ST-fed LV grid,controlling the ST output voltage.The last feature has two main effects:the first is to reduce the active power withdrawn from MV grid,and consequently the MV voltage drop caused by the active current component.At the same time,higher reactive power injection capability in the MV converter is unlocked,due to the lower active power demand.As result,the ST increases the voltage support in MV grid.The analysis and simulation results carried out in this paper show improvements compared to similar solutions,i.e.the only reactive power compensation.The impact of the proposed solution has been finally evaluated under different voltage-dependence of the loads in the LV grid.Stefano Giacomuzzi Marius Langwasser Giovanni De Carne Giuseppe Buja Marco Liserre 2020CES Transactions on Electrical Machines and Systems2020,4,4:5
3Myocardial ischemia and reperfusion injury显示文摘L. Maximilian Buja 2005Cardiovascular Pathology2005,,4:2
4Hypertrophic cardiomyopathy and sudden death in the young: Pathologic evidence of myocardial ischemia显示文摘Cristina Basso Gaetano Thiene Domenico Corrado Gianfranco Buja Paola Melacini Andrea Nava 2000Human Pathology2000,,8:2
5Interactive High-Dimensional Data Visualization 显示文摘Buja A Cook D Swayne D F 1996Journal of Computational and Graphical Statistics1996,5,1:2
6Interactive high-dimensional data visualization显示文摘BUJA A COOK D SWAYNE D 1996Journal of Computational and Graphical Statistics1996,5,:1
7Biomagnification of perfluoroalkylcompounds in the bottlenose dolphin ( Turs iops truncatus) food web显示文摘Houde M Bujas T A Small J 2006Environmental Science and Technology2006,40,13:1
8Vascular responses to percutaneous coronary intervention with bare-metal stents and drug-eluting stents: A perspective based on insights from pathological and clinical studies 显示文摘Buja LM 2011J Am Coil Cardiol2011,57,:1
9Stimulation of mitochondr- ial biogenesis and autophagy by lipopolysaccharide in the neonatal rat cardiomyocyte protects against programmed cell death 显示文摘Hickson-Bick DL Jones C Buja LM 2008J Mol Cell Cardiol2008,44,2:1
10Health care service usage and costs for high-needs elderly patients with heart failure显示文摘Heart failure(HF)has been defined as global disease of pandemic proportions,since it affects around 26 million people worldwide.[1]According to a recent study,age is the most important factor influencing the prevalence of HF,as it is for most other chronic conditions.[2]This means that,with the predicted aging of the population(the proportion of the world’s population aged 60 years and over will nearly double from 2015 to 2050),[3]there will be a growth in the total burden of HF,and a rise in the number of comorbidities in HF patients.According to a recent study,almost 86%of adults with HF have two or more comorbid conditions.[4]Comorbidity,defined as the co-existence of one or more additional conditions in individuals with a specified index medical condition,[5]adds to the complexity of treating elderly patients with HF.Alessandra Buja Riccardo Caberlotto Carlo Pinato Giulia Grotto Maria Chiara Corti Francesco Avossa Elena Schievano Vincenzo Baldo 2020Journal of Geriatric Cardiology2020,17,9:1
11Stenosis of the right pulmonary artery : A complication of acute d ssect ng aneurysm of theascending aorta显示文摘Buja LM Ali N Fletcher RD 1972Am Heart J1972,83,:1
12Computed tomography: in vitro evaluation of myocardial infarction 显示文摘Gray WR Jr Parkey RW Buja LM 1977Radiology1977,122,2:1
13Optimum output waveforms in PWM inverters显示文摘Buja G S 1980IEEE Transactions on Industry Applications1980,16,6:1
14Oncosis: an important non-apo- ptotic mode of cell death显示文摘Weerasinghe P Buja LM 2012Exp Mol Pathol2012,93,3:1
15Direct torque control of an induction motor using a single current sensor显示文摘BERTOLUZZO M BUJA G MENIS R 2006IEEE Transactions on Industrial Electronics2006,53,3:1
16Fibrosis and heart failure 显示文摘Segura AM Frazier OH Buja LM 2014Heart Fail Rev2014,19,2:1
17Signal-averaged electrocardiography in familial form of arrhythmogenic right ventricular cardiomyopathy显示文摘Oselladore L Nava A Buja G 1995Am J Cardiol1995,75,:1
18Optimal pulse width modulation for feeding AC motors显示文摘Buja G S Indri G B 1977IEEE Transactions on Industry Applications1977,13,1:1
19Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS显示文摘HICKSON-BICK D L SPARAGNA G C BUJA L M 2002Am J Physiol Heart Circ Physiol2002,282,2:1
20Cardiomyocytes death and renewal in the normal and diseased heart显示文摘Buja LM Vela D 2008Cardiovasc Pathol2008,17,6:1
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