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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 3 | Behavior of brain perfusion with SPECT tomography 99mTc ethylene dicysteine (ECD) in alcohol and cocaine dependents during abstinence显示文摘 | Pallavicini Gonzalez J Massardo Vega T Arancibia Soto P | 2002 | Rev Esp Med Nucl2002，21，6： | 1 |
| 4 | A neural - networks - based adaptive disturbance rejection meth- od and its application to the control of hard disk drives 显示文摘 | LEVIN J PEREZ - ARANCIBIA N O IOANNOU P A | 2009 | IEEE Transactions on Magnetics Part 12009，45，5： | 1 |
| 5 | Biofiltra tion of high concentration of hydrogen sulphide using thioba cillus thioparus 显示文摘 | OYARZUN P ARANCIBIA F CANALES C | 2003 | Process Biochemistry2003，39，2： | 1 |
| 6 | Biofihration of High Concen tration of Hydrogen Sulphide Using Thiobacillus thioparus显示文摘 | Oyarzun P Arancibia F Canales C | 2003 | Press Biochem2003，39，2： | 1 |
| 7 | Importance of Legionella pneumophila in the etiology of severe community-acquiredpneumonia in Santiago, Chile显示文摘 | Arancibia F Cortes C P Vald 6 s M | 2014 | Chest2014，145，2： | 1 |
| 8 | Treatment of diffuse hyper- thyroid goiter with radioiodine: influence of propylthiouracil pretreatment 显示文摘 | Veliz J Plineda G Arancibia P | 2000 | Rev Med Chil2000，128，6： | 1 |
| 9 | Comparison on the removal of hydrogen sulfide in biotrickling filters inoculated with Thiobacillus thioparus and Acidithiobacillus thiooxidans 显示文摘 | Aroca G Urrutia H Nunez D Oyarzun P Arancibia A Guerrero K | 2007 | Electron J Biotechnol2007，10，4： | 1 |
| 10 | Importance of Legionella pneumophila in the etiology of severe community-acquired pneumonia in Santiago, Chile 显示文摘 | Arancibia F Cortes C P Vald6s M | 2014 | Chest2014，145，2： | 1 |
| 11 | Treatment of diffuse hyperthyroid goiter with radiodine:in-fluence of propylthiouracil preteatment显示文摘 | Veliz plineda G arancibia P | 2000 | Rev Medchil2000，128，： | 1 |
| 12 | Distribution of copper, zinc, lead and cadmium concentrations in stream sedi- ments from the Mapocho River in Santiago, Chile 显示文摘 | Segura R Arancibia V Ztiffiga M C Past6n P | 2006 | Journal of Geochemical Exploration2006，91，： | 1 |
| 13 | Biofiltration of high concentration of hydrogen sulphide using Thiobacillus thioparus显示文摘 | Oyarzu P Arancibia F Canales C | 2003 | Process Biochemistry2003，39，： | 1 |
| 14 | Biofihration of high concentration of hydrogen sulphide using Thiobacillus thiooarus显示文摘 | Oyarzǜn P Arancibia F Canales C | 2003 | Process Biochemistry2003，39，： | 1 |
| 15 | Biofihration of high concentration of hydrogen sulphide using Thiobacillus thioparus显示文摘 | Oyarzun P Arancibia F Canales C | 2003 | Process Biochemistry2003，39，： | 1 |
| 16 | Antioxidant properties of durian fruit as influenced by ripening 显示文摘 | Arancibia - Avila P Toledo F Park YS | 2008 | LWT-Food Science and Technology2008，41，10： | 1 |
| 17 | Biofiltration of high concentration of hydrogen sulphide using thiobacillus thioparus显示文摘 | Oyarzun P Arancibia F Canales C | 2003 | Process Biochemistry2003，39，： | 1 |
| 18 | Biofiltra- t/on of high concentration of hydrogen sulphide using Thiobacillus thioparus 显示文摘 | Oyarztn P F Arancibia C Canales E G Aroca | 2003 | Process Biochemistry2003，39，： | 1 |
| 19 | Results from a long term prospective study显示文摘 | Hamilfon F Pineda G Arancibia P | 1991 | Clin Exp lmmunol1991，83，： | 1 |
| 20 | Behavior of brain perfusion with SPECT tomography 99mTc ethylene dicysteine (ECD) in alcohol and cocaine dependents during abstinence 显示文摘 | Pallavicini G J Massardo V T Arancibia S P | 2002 | Rev Esp Med Nucl2002，21，6： | 1 |
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