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| 1 | 重组葡激酶与重组组织型纤溶酶原激活剂治疗急性心肌梗死的随机多中心临床试验显示文摘目的研究新型溶栓剂——重组葡激酶(r-Sak)治疗急性心肌梗死(AMI)的冠状动脉通畅率、临床疗效及安全性。方法本研究为多中心、随机、平行对照临床试验,入选发病12 h 内、年龄≤70岁、ST 段抬高的 AMI 患者,随机分为 r-Sak 组104例,给予 r-Sak 3 mg 静注,12 mg 于30 min 内静脉输注,总量15 mg;重组组织型纤溶酶原激活剂(rt-PA)组106例,8 mg 静注,42 mg 在90 min 内输注,总量50 mg。全部患者给予阿司匹林和静脉输注肝素,于用药90 min 行冠状动脉造影,对 TIMI 血流0~2级者行补救性 PCI。结果主要终点:用药90 min 冠状动脉通畅率(TIMI 血流2级或3级),r-Sak 组明显高于 rt-PA 组(77.8%比63.6%,P=0.0277),TIMI 3级者两组间差异无统计学意义(57.6%比48.5%,P=0.1929);1个月内死亡(8.7%比5.7%,P=0.3997)、非致死性再梗死(2.9%比3.8%,P=1.0000)、心肌缺血复发(8.7%比16.0%,P=0.1043)和复合临床终点(18.3%比21.7%,P=0.5345)两组间差异均无统计学意义。次要终点:r-Sak 组出血发生率(28.8%)与 rt-PA组(27.4%)比较,差异无统计学意义(P=0.8105),其中严重或威胁生命的出血,两组间差异亦无统计学意义(1.9%比3.8%),r-Sak 组脑出血1例(0.96%),rt-PA 组脑出血4例(3.85%)。无其他药物相关的严重不良反应及过敏反应发生。结论 r-Sak 是一种安全、有效的治疗 AMI 的溶栓药物,其疗效及安全性至少与 rt-PA 50 mg 相似。 | Collaborative Research Group of Reperfusion Therapy in Acute Myocardial Infarction | 2007 | 中华心血管病杂志2007，35，8： | 43 |
| 2 | 90分钟冠状动脉造影评价急性心肌梗塞血管开通及临床再通指标价值显示文摘通过经静脉溶栓开始后90分钟冠状动脉造影(CAG),观察国产尿激酶(天普洛欣,UKTP)静脉溶栓治疗急性心肌梗塞(AMI)血管开通疗效,并评价临床再灌注标准的判断价值如何。方法:从UKTP多中心治疗AMI1406例中,汇集其中所行冠状动脉造影(CAG)共124例资料。结果提示:(1)124例AMI患者,在溶栓开始后90分钟时的梗塞相关血管的血流达TIMIⅢ级者52例(41.9%)、Ⅱ级38例(30.7%),梗塞相关血管再开通率为72.6%;(2)溶栓距起病时间愈早,具有愈高的开通趋势,但差异无统计学意义;(3)以CAG为金标准,临床标准对血管开通判断敏感性为88%,特异性为69%,准确性为83%。结论:UKTP静脉溶栓治疗AMI血管开通疗效肯定,临床标准判断血管再通的敏感性较高,但特异性欠佳,有待提高。 | The multicentre investigating group of thrombolytic therapy on acute myocardial infarction with Urokinase Techpool Correspondence: Hu Dayi, Xu Zhimin. Chaoyang Red Cross Hospital, Capital University of Medical Sciences, Beijing 100020 | 1997 | 中华心血管病杂志1997，25，4： | 11 |
| 3 | 急性高血糖对ST段抬高性心肌梗死院内预后的影响显示文摘目的探讨急性高血糖对 ST 段抬高性心肌梗死(STEMI)患者院内预后的影响。方法连续入选356例北京地区17家三级和二级医院所有在24h 内入院且符合 STEMI 诊断标准的患者。以人院血糖水平>11mmol/L 判定为高血糖,分为高血糖组和血糖正常组,观察两组患者院内死亡和心血管病事件的发生情况。院内心血管事件定义为院内再发心肌梗死、新发生的心力衰竭、严重心律失常及卒中。结果 356例 STEMI 患者中,存在急性高血糖患者共81例(22.8%)。其院内病死率较无急性高血糖患者显著增加(13.6%比5.1%,P=0.009),院内心血管事件发生率亦显著增多(32.1%比20.4%,P=0.027)。logistic 回归分析示,入院急性高血糖(OR 1.615,95%CI 1.116~2.338,P=0.011)为 STEMI 患者院内不良预后的独立危险因素。结论 STEMI 急性高血糖患者院内死亡及发生院内心血管事件的危险性显著高于入院血糖正常者。入院高血糖为 STEMI 患者院内不良预后的独立危险因素。 | Registry of acute treatment in myocardial infarction investigators. | 2007 | 中华内科杂志2007，46，10： | 9 |
| 4 | Rapid detection of sepsis complicating acute necrotizing pancreatitis using polymerase chain reaction显示文摘INTRODUCTIONAcute narcotizing pancreatitis usually takes a severe clinical course and is associated with multiple organ dysfunction .With the further understanding of pathophysiological events of acute pancreatisis and the therapeutic measuses taken by the clinicians ,the patients can pass through the critical carry stages ,and then the septic complication caused by rtanslocated bacteria, mostly gram-negative microbes from the intestines ensues[1]. | Wei Zhong Zhang1 Tian Quan Han2 Yao Qing Tang2 Sheng Dao Zhang2 1Department of Surgery. Huangyan First Hospital, Huangyan 318020, Zhejiang Province. China 2Department of Surgery. Ruijin Hospital. Shanghai Second Medical University. Shanghai 200025. ChinaDr. Wei Zhong Zhang, graduated from Shanghai Second MedicalUniversity receiving master degree of surgery in 1999 he is devoted to basic and clinical investigation on severe acute pancreatitis and has one paper published. | 2001 | World Journal of Gastroenterology2001，7，2： | 7 |
| 5 | Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones显示文摘BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2 ( SCP2 ) participates in choles- terol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in pa- tients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2 mRNA was studi- ed in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-poly- merase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in pa- tients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone. | Nai-Qiang Cui, Shu-Kun Zhang, Yun-Feng Cui, Dong-Hua Li,Chang Chen and Xian-Zhong Wu Tianjin, China Institute of Acute Abdominal Diseases and Department of Surgery | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 5 |
| 6 | Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management 显示文摘 | American Society of Anesthesiologists Task Force on Acute Pain Management | 2004 | Anesthesiology2004，100，6： | 1 |
| 7 | The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)显示文摘 | Guidelines on the diagnosis and managemenlof acute puhnonary embolism | 2008 | Eur Heart J2008，29，18： | 1 |
| 8 | The Acute Respiratory Distress Syndrome Network显示文摘 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome | 2000 | N Engl J Med2000，342，18： | 1 |
| 9 | syndromes显示文摘 | Quilici j Banzet N Paule P Circulating endothelial cell count as a diagnostic marker for non-ST-elevation acute coronary | 2004 | Circulation2004，110，10： | 1 |
| 10 | Intensity of Renal Support in Critically Ⅲ Patients with Acute Kidney Injury显示文摘 | The VA/NIH Acute Renal Failure Trial Network | 2008 | N Engl J Med2008，359，1： | 1 |
| 11 | A controlled trial 显示文摘 | Kleinknecht D Ganeval D Gonzalez-Duque LA Furo-semide in acute oliguric renal failure | 1976 | Nephron1976，17，1： | 1 |
| 12 | Circulation显示文摘 | Hama N Rapid ventricular induction ofbrain natriuretic peptide geneexpression in experimental acute myocardial infarction | 1995 | 92(6): 1558- 15641995，92，6： | 1 |
| 13 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST - segment elevation 显示文摘 | Task Force on the management of ST - segment elevation acute myocardial infarction of the European Society of Cardiology ( ESC ) Steg PG James SK | 2012 | Eur Heart J2012，33，20： | 1 |
| 14 | American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists 显示文摘 | Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning | 1999 | J Toxicol Clin Toxicol1999，37，6： | 1 |
| 15 | Prioritizing interventions to improve rates of thrombolysis for ischemic stroke 显示文摘 | California Acute Stroke Pilot Registry (CASPR) Investigators | 2005 | Neurology2005，64，4： | 1 |
| 16 | ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008显示文摘 | The task Force for Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of European Society of Cardiology | 2008 | European Heart Journal2008，，29： | 1 |
| 17 | CAST:randomized placebo - controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroker显示文摘 | Chinese acute stroke trial collaborative group | 1997 | Lancet1997，349，： | 1 |
| 18 | Fewer immediate complications than with surgery, but more subsequent failures 显示文摘 | Antibiotic therapy for acute appendicitis in adults | 2014 | Prescrire Int2014，23，150： | 1 |
| 19 | Members of the Piracetam in Acute Stroke Study (PASS) Group显示文摘 | De Deyn PP Reuck JD Deberdt W Treatment of acute ischemic stroke with piracetam | 1997 | Stroke1997，28，12： | 1 |
| 20 | Effect of a novel free radical scavenger,edaravone(MCl-186),on acute brain infarction, randomized, placebc - controlled, doubleblind study at mutticenters显示文摘 | Edaravone acute infarction study group | 2003 | Cerebrovasc Dis2003，15，3： | 1 |
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