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2篇 您的检索式:作者名="Zuming Lin"
    题名 作者 年代 出处 被引量
1Aza-Bellus-Claisen Rearrangement-Enabled Synthesis of Racemic Tapentadol and Its Stereoisomers显示文摘Donghu Bai Sha-Hua Huang Zuming Lin Lin Yang Junzeng Dai Meng-Yuan Huang Xueshun Jia Ran Hong 2013Chinese Journal of Chemistry2013,31,3:0
2A Modular Synthesis of Antitumor Macrolide (-)-Lasonolide A显示文摘Lasonolide A was identified as a potent antitumor macrolide towards various cancer cell lines.The two tetrahydropyrans bearing multiple stereogenic centers as well as the polyvene linkage attracted a dozen synthetic research groups to launch the total syn-thesis.Based on the synthetic methods developed in our group,namely,the hydroboration of allene and its subsequent allylation as well as the iterative hydroboration of allene and oxidation,the polyol subunits were efficiently constructed and then integrated into the final target.A new Julia olefination reagent,double-headed sulfone,was designed to promote the rapid coupling of two aldehydes bearing multiple functional groups to secure the whole carbon framework.Another highlight of our approach is the application of a traceless protecting group,9-BBN(9-borabicyclo[3.3.1]nonane),to hide the secondary alcohol for debenzylation,and for the first time,to mask the carboxylic acid for Julia olefination under strong basic conditions.Lin Yang Zuming Lin Kuan Zheng Luyao Kong Ran Hong 2020Chinese Journal of Chemistry2020,38,7:0
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